Predictors of ovarian response in intrauterine insemination patients and development of a dosage nomogram

Nina La Cour Freiesleben; K. Lossl; Jeanette Wulff Bogstad; H.E. Bredkjaer; B. Toft; Anne Loft; S. Bangsboll; A. Pinborg; Esben Budtz-Jørgensen; Anders Nyboe Andersen; Annika Ingeborg Loft Jakobsen

Predictors of ovarian response in intrauterine insemination patients and development of a dosage nomogram

Nina La Cour Freiesleben, K. Lossl, Jeanette Wulff Bogstad, H.E. Bredkjaer, B. Toft, Anne Loft, S. Bangsboll, A. Pinborg, Esben Budtz-Jørgensen, Anders Nyboe Andersen, Annika Ingeborg Loft Jakobsen

12 Citations (Scopus)

Abstract

The objective of this prospective study was to identify predictors of ovarian response in ovulatory patients treated with low-dose recombinant FSH (rFSH), gonadotrophin-releasing hormone antagonist and intrauterine insemination (IUI), and to develop an rFSH dosage nomogram based on the findings. Patients (n = 159) were stimulated with a starting dose of 75 IU rFSH/day. Ten parameters were investigated as possible predictors of the number of mature follicles >or=15 mm: age, spontaneous cycle length, body weight, body mass index, smoking status, total ovarian volume, total number of antral follicles, total Doppler score of the ovarian stromal blood flow, baseline FSH and oestradiol. Simple and multiple linear regressions were used for the statistical analysis. Appropriate ovarian response was defined as two to three mature follicles. Body weight (P = 0.001) and the number of antral follicles (P = 0.004) were the strongest independent predictive factors of the number of mature follicles. In conclusion, body weight and antral follicle count may be used to achieve appropriate ovarian response for IUI in ovulatory patients. Based on this, a simple rFSH dosage nomogram was developed for individual ovarian stimulation prior to IUI.

Original language	English
Journal	Reproductive BioMedicine Online
Volume	17
Issue number	5
Pages (from-to)	632-641
Number of pages	9
ISSN	1472-6483
Publication status	Published - 2008

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@article{2b426e30f6aa11ddbf70000ea68e967b,

title = "Predictors of ovarian response in intrauterine insemination patients and development of a dosage nomogram",

abstract = "The objective of this prospective study was to identify predictors of ovarian response in ovulatory patients treated with low-dose recombinant FSH (rFSH), gonadotrophin-releasing hormone antagonist and intrauterine insemination (IUI), and to develop an rFSH dosage nomogram based on the findings. Patients (n = 159) were stimulated with a starting dose of 75 IU rFSH/day. Ten parameters were investigated as possible predictors of the number of mature follicles >or=15 mm: age, spontaneous cycle length, body weight, body mass index, smoking status, total ovarian volume, total number of antral follicles, total Doppler score of the ovarian stromal blood flow, baseline FSH and oestradiol. Simple and multiple linear regressions were used for the statistical analysis. Appropriate ovarian response was defined as two to three mature follicles. Body weight (P = 0.001) and the number of antral follicles (P = 0.004) were the strongest independent predictive factors of the number of mature follicles. In conclusion, body weight and antral follicle count may be used to achieve appropriate ovarian response for IUI in ovulatory patients. Based on this, a simple rFSH dosage nomogram was developed for individual ovarian stimulation prior to IUI.",

author = "Freiesleben, {Nina La Cour} and K. Lossl and Bogstad, {Jeanette Wulff} and H.E. Bredkjaer and B. Toft and Anne Loft and S. Bangsboll and A. Pinborg and Esben Budtz-J{\o}rgensen and Andersen, {Anders Nyboe} and Jakobsen, {Annika Ingeborg Loft}",

year = "2008",

language = "English",

volume = "17",

pages = "632--641",

journal = "Reproductive BioMedicine Online",

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TY - JOUR

T1 - Predictors of ovarian response in intrauterine insemination patients and development of a dosage nomogram

AU - Freiesleben, Nina La Cour

AU - Lossl, K.

AU - Bogstad, Jeanette Wulff

AU - Bredkjaer, H.E.

AU - Toft, B.

AU - Loft, Anne

AU - Bangsboll, S.

AU - Pinborg, A.

AU - Budtz-Jørgensen, Esben

AU - Andersen, Anders Nyboe

AU - Jakobsen, Annika Ingeborg Loft

PY - 2008

Y1 - 2008

N2 - The objective of this prospective study was to identify predictors of ovarian response in ovulatory patients treated with low-dose recombinant FSH (rFSH), gonadotrophin-releasing hormone antagonist and intrauterine insemination (IUI), and to develop an rFSH dosage nomogram based on the findings. Patients (n = 159) were stimulated with a starting dose of 75 IU rFSH/day. Ten parameters were investigated as possible predictors of the number of mature follicles >or=15 mm: age, spontaneous cycle length, body weight, body mass index, smoking status, total ovarian volume, total number of antral follicles, total Doppler score of the ovarian stromal blood flow, baseline FSH and oestradiol. Simple and multiple linear regressions were used for the statistical analysis. Appropriate ovarian response was defined as two to three mature follicles. Body weight (P = 0.001) and the number of antral follicles (P = 0.004) were the strongest independent predictive factors of the number of mature follicles. In conclusion, body weight and antral follicle count may be used to achieve appropriate ovarian response for IUI in ovulatory patients. Based on this, a simple rFSH dosage nomogram was developed for individual ovarian stimulation prior to IUI.

AB - The objective of this prospective study was to identify predictors of ovarian response in ovulatory patients treated with low-dose recombinant FSH (rFSH), gonadotrophin-releasing hormone antagonist and intrauterine insemination (IUI), and to develop an rFSH dosage nomogram based on the findings. Patients (n = 159) were stimulated with a starting dose of 75 IU rFSH/day. Ten parameters were investigated as possible predictors of the number of mature follicles >or=15 mm: age, spontaneous cycle length, body weight, body mass index, smoking status, total ovarian volume, total number of antral follicles, total Doppler score of the ovarian stromal blood flow, baseline FSH and oestradiol. Simple and multiple linear regressions were used for the statistical analysis. Appropriate ovarian response was defined as two to three mature follicles. Body weight (P = 0.001) and the number of antral follicles (P = 0.004) were the strongest independent predictive factors of the number of mature follicles. In conclusion, body weight and antral follicle count may be used to achieve appropriate ovarian response for IUI in ovulatory patients. Based on this, a simple rFSH dosage nomogram was developed for individual ovarian stimulation prior to IUI.

M3 - Journal article

SN - 1472-6483

VL - 17

SP - 632

EP - 641

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

IS - 5

ER -

Predictors of ovarian response in intrauterine insemination patients and development of a dosage nomogram

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