Predictive value of soluble haemoglobin scavenger receptor CD163 serum levels for survival in verified tuberculosis patients

T B Knudsen; P Gustafson; G Kronborg; T B Kristiansen; S K Moestrup; J O Nielsen; V Gomes; P Aaby; I Lisse; H J Møller; J Eugen-Olsen; Troels Bygum Knudsen

doi:10.1111/j.1469-0691.2005.01229.x

Predictive value of soluble haemoglobin scavenger receptor CD163 serum levels for survival in verified tuberculosis patients

T B Knudsen, P Gustafson, G Kronborg, T B Kristiansen, S K Moestrup, J O Nielsen, V Gomes, P Aaby, I Lisse, H J Møller, J Eugen-Olsen, Troels Bygum Knudsen

Department of Clinical Medicine

42 Citations (Scopus)

Abstract

Pre-treatment serum levels of sCD163 were measured in a cohort of 236 suspected tuberculosis (TB) cases from Guinea-Bissau, with a median follow-up period of 3.3 years (range 0-6.4 years). In 113 cases, the diagnosis of TB was verified by positive sputum microscopy and/or culture. Among the verified TB cases, a decreased survival rate was found in 27 patients with sCD163 levels above the upper reference limit (3.95 microg/mL). The difference in survival was significant during TB treatment (log rank, p<0.02) and after long-term follow-up (log rank, p<0.001). The decrease in survival rate during TB treatment remained significant in a multivariate Cox model controlling for human immunodeficiency virus (HIV) status, age and gender, with a mortality increase of 1.19 (95% CI, 1.04-1.36) per microg of sCD163, and a hazard ratio (HR) for sCD163 levels above the upper reference limit of 4.18 (95% CI, 1.06-16.4). The difference was not significant after excluding patients with concomitant HIV-1 and HIV-2 infection in Kaplan-Meier analyses (log rank, p 0.11). In contrast, the difference in survival remained significant in Kaplan-Meier analyses after long-term follow-up, even after excluding patients with concomitant HIV-1 and HIV-2 infection (log rank, p 0.002). In the Cox model, the mortality increase per microg of sCD163 was 1.27 (95% CI, 1.14-1.40), with an HR for elevated sCD163 levels of 2.85 (95% CI, 1.44-5.63). The HRs for concomitant HIV-1 and HIV-2 infection were 6.92 (95% CI, 3.28-14.58) and 2.48 (95% CI, 1.09-5.67), respectively. Thus, sCD163 levels appeared to be an independent predictor of survival in verified TB patients.

Original language	English
Journal	Clinical Microbiology and Infection
Volume	11
Issue number	9
Pages (from-to)	730-5
Number of pages	5
ISSN	1198-743X
DOIs	https://doi.org/10.1111/j.1469-0691.2005.01229.x https://doi.org/10.1111/j.1469-0691.2005.01229.x
Publication status	Published - 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16104988&query_hl=16

Cite this

Knudsen, T. B., Gustafson, P., Kronborg, G., Kristiansen, T. B., Moestrup, S. K., Nielsen, J. O., Gomes, V., Aaby, P., Lisse, I., Møller, H. J., Eugen-Olsen, J., & Knudsen, T. B. (2005). Predictive value of soluble haemoglobin scavenger receptor CD163 serum levels for survival in verified tuberculosis patients. Clinical Microbiology and Infection, 11(9), 730-5. https://doi.org/10.1111/j.1469-0691.2005.01229.x, https://doi.org/10.1111/j.1469-0691.2005.01229.x

Knudsen, TB, Gustafson, P, Kronborg, G, Kristiansen, TB, Moestrup, SK, Nielsen, JO, Gomes, V, Aaby, P, Lisse, I, Møller, HJ, Eugen-Olsen, J & Knudsen, TB 2005, 'Predictive value of soluble haemoglobin scavenger receptor CD163 serum levels for survival in verified tuberculosis patients', Clinical Microbiology and Infection, vol. 11, no. 9, pp. 730-5. https://doi.org/10.1111/j.1469-0691.2005.01229.x, https://doi.org/10.1111/j.1469-0691.2005.01229.x

@article{5d3ceee78de14212bdccdcffae99c791,

title = "Predictive value of soluble haemoglobin scavenger receptor CD163 serum levels for survival in verified tuberculosis patients",

abstract = "Pre-treatment serum levels of sCD163 were measured in a cohort of 236 suspected tuberculosis (TB) cases from Guinea-Bissau, with a median follow-up period of 3.3 years (range 0-6.4 years). In 113 cases, the diagnosis of TB was verified by positive sputum microscopy and/or culture. Among the verified TB cases, a decreased survival rate was found in 27 patients with sCD163 levels above the upper reference limit (3.95 microg/mL). The difference in survival was significant during TB treatment (log rank, p<0.02) and after long-term follow-up (log rank, p<0.001). The decrease in survival rate during TB treatment remained significant in a multivariate Cox model controlling for human immunodeficiency virus (HIV) status, age and gender, with a mortality increase of 1.19 (95% CI, 1.04-1.36) per microg of sCD163, and a hazard ratio (HR) for sCD163 levels above the upper reference limit of 4.18 (95% CI, 1.06-16.4). The difference was not significant after excluding patients with concomitant HIV-1 and HIV-2 infection in Kaplan-Meier analyses (log rank, p 0.11). In contrast, the difference in survival remained significant in Kaplan-Meier analyses after long-term follow-up, even after excluding patients with concomitant HIV-1 and HIV-2 infection (log rank, p 0.002). In the Cox model, the mortality increase per microg of sCD163 was 1.27 (95% CI, 1.14-1.40), with an HR for elevated sCD163 levels of 2.85 (95% CI, 1.44-5.63). The HRs for concomitant HIV-1 and HIV-2 infection were 6.92 (95% CI, 3.28-14.58) and 2.48 (95% CI, 1.09-5.67), respectively. Thus, sCD163 levels appeared to be an independent predictor of survival in verified TB patients.",

author = "Knudsen, {T B} and P Gustafson and G Kronborg and Kristiansen, {T B} and Moestrup, {S K} and Nielsen, {J O} and V Gomes and P Aaby and I Lisse and M{\o}ller, {H J} and J Eugen-Olsen and Knudsen, {Troels Bygum}",

year = "2005",

doi = "10.1111/j.1469-0691.2005.01229.x",

language = "English",

volume = "11",

pages = "730--5",

journal = "Clinical Microbiology and Infection",

issn = "1198-743X",

publisher = "Elsevier",

number = "9",

}

TY - JOUR

T1 - Predictive value of soluble haemoglobin scavenger receptor CD163 serum levels for survival in verified tuberculosis patients

AU - Knudsen, T B

AU - Gustafson, P

AU - Kronborg, G

AU - Kristiansen, T B

AU - Moestrup, S K

AU - Nielsen, J O

AU - Gomes, V

AU - Aaby, P

AU - Lisse, I

AU - Møller, H J

AU - Eugen-Olsen, J

AU - Knudsen, Troels Bygum

PY - 2005

Y1 - 2005

N2 - Pre-treatment serum levels of sCD163 were measured in a cohort of 236 suspected tuberculosis (TB) cases from Guinea-Bissau, with a median follow-up period of 3.3 years (range 0-6.4 years). In 113 cases, the diagnosis of TB was verified by positive sputum microscopy and/or culture. Among the verified TB cases, a decreased survival rate was found in 27 patients with sCD163 levels above the upper reference limit (3.95 microg/mL). The difference in survival was significant during TB treatment (log rank, p<0.02) and after long-term follow-up (log rank, p<0.001). The decrease in survival rate during TB treatment remained significant in a multivariate Cox model controlling for human immunodeficiency virus (HIV) status, age and gender, with a mortality increase of 1.19 (95% CI, 1.04-1.36) per microg of sCD163, and a hazard ratio (HR) for sCD163 levels above the upper reference limit of 4.18 (95% CI, 1.06-16.4). The difference was not significant after excluding patients with concomitant HIV-1 and HIV-2 infection in Kaplan-Meier analyses (log rank, p 0.11). In contrast, the difference in survival remained significant in Kaplan-Meier analyses after long-term follow-up, even after excluding patients with concomitant HIV-1 and HIV-2 infection (log rank, p 0.002). In the Cox model, the mortality increase per microg of sCD163 was 1.27 (95% CI, 1.14-1.40), with an HR for elevated sCD163 levels of 2.85 (95% CI, 1.44-5.63). The HRs for concomitant HIV-1 and HIV-2 infection were 6.92 (95% CI, 3.28-14.58) and 2.48 (95% CI, 1.09-5.67), respectively. Thus, sCD163 levels appeared to be an independent predictor of survival in verified TB patients.

AB - Pre-treatment serum levels of sCD163 were measured in a cohort of 236 suspected tuberculosis (TB) cases from Guinea-Bissau, with a median follow-up period of 3.3 years (range 0-6.4 years). In 113 cases, the diagnosis of TB was verified by positive sputum microscopy and/or culture. Among the verified TB cases, a decreased survival rate was found in 27 patients with sCD163 levels above the upper reference limit (3.95 microg/mL). The difference in survival was significant during TB treatment (log rank, p<0.02) and after long-term follow-up (log rank, p<0.001). The decrease in survival rate during TB treatment remained significant in a multivariate Cox model controlling for human immunodeficiency virus (HIV) status, age and gender, with a mortality increase of 1.19 (95% CI, 1.04-1.36) per microg of sCD163, and a hazard ratio (HR) for sCD163 levels above the upper reference limit of 4.18 (95% CI, 1.06-16.4). The difference was not significant after excluding patients with concomitant HIV-1 and HIV-2 infection in Kaplan-Meier analyses (log rank, p 0.11). In contrast, the difference in survival remained significant in Kaplan-Meier analyses after long-term follow-up, even after excluding patients with concomitant HIV-1 and HIV-2 infection (log rank, p 0.002). In the Cox model, the mortality increase per microg of sCD163 was 1.27 (95% CI, 1.14-1.40), with an HR for elevated sCD163 levels of 2.85 (95% CI, 1.44-5.63). The HRs for concomitant HIV-1 and HIV-2 infection were 6.92 (95% CI, 3.28-14.58) and 2.48 (95% CI, 1.09-5.67), respectively. Thus, sCD163 levels appeared to be an independent predictor of survival in verified TB patients.

U2 - 10.1111/j.1469-0691.2005.01229.x

DO - 10.1111/j.1469-0691.2005.01229.x

M3 - Journal article

C2 - 16104988

SN - 1198-743X

VL - 11

SP - 730

EP - 735

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 9

ER -

Predictive value of soluble haemoglobin scavenger receptor CD163 serum levels for survival in verified tuberculosis patients

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this