Prebiotic enhancement of probiotic potential: oligosaccharides triggering modification of protein profiles in lactic acid bacteria

TY - CHAP

T1 - Prebiotic enhancement of probiotic potential

T2 - oligosaccharides triggering modification of protein profiles in lactic acid bacteria

AU - Majumder, Avishek

AU - Hansen, Morten Ejby

AU - van Zanten, Gabriella Christina

AU - Knudsen, Anne

AU - Lahtinen, Sampo J.

AU - Svensson, Birte

AU - Jacobsen, Susanne

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The human gastrointestinal tract (GIT) is colonized by a large, active and highly diverse microbial community (Eckburg et al. 2005). From a nutritional viewpoint, intestinal bacteria can be divided into saccharolytic and proteolytic species, depending on whether they obtain energy by sugar fermentation (or oxidation), or by protein putrefaction. It is well established that the metabolic activity of proteolytic bacteria leads to biosynthesis and release of toxic and mutagenic molecules such as phenols, thiols, indole, amines and ammonia. Actually, it has been demonstrated that a diet rich in animal fat, which contributes to selection and proliferation of proteolytic species, is epidemiologically linked to colon cancer (Hill 1975). On the contrary a fiber-rich diet can favour saccharolytic species which are generally beneficial for the host. Nevertheless, it should be considered that the diet of modern humans is very different from that of our ancestors: of the ~500 different kinds of vegetables consumed worldwide on a yearly basis, less than 50 are currently consumed in western countries, where diet is chiefly based on meat, saturated fats and fiber-poor carbohydrates.

AB - The human gastrointestinal tract (GIT) is colonized by a large, active and highly diverse microbial community (Eckburg et al. 2005). From a nutritional viewpoint, intestinal bacteria can be divided into saccharolytic and proteolytic species, depending on whether they obtain energy by sugar fermentation (or oxidation), or by protein putrefaction. It is well established that the metabolic activity of proteolytic bacteria leads to biosynthesis and release of toxic and mutagenic molecules such as phenols, thiols, indole, amines and ammonia. Actually, it has been demonstrated that a diet rich in animal fat, which contributes to selection and proliferation of proteolytic species, is epidemiologically linked to colon cancer (Hill 1975). On the contrary a fiber-rich diet can favour saccharolytic species which are generally beneficial for the host. Nevertheless, it should be considered that the diet of modern humans is very different from that of our ancestors: of the ~500 different kinds of vegetables consumed worldwide on a yearly basis, less than 50 are currently consumed in western countries, where diet is chiefly based on meat, saturated fats and fiber-poor carbohydrates.

U2 - 10.1201/b16439-12

DO - 10.1201/b16439-12

M3 - Book chapter

SN - 978-1-4665-7555-4

SP - 233

EP - 253

BT - Interactive probiotics

A2 - Pessione, Erica

PB - CRC Press

ER -