Polycomb group proteins in cell cycle progression and cancer.

TY - JOUR

T1 - Polycomb group proteins in cell cycle progression and cancer.

AU - Pasini, Diego

AU - Bracken, Adrian P

AU - Helin, Kristian

N1 - Keywords: Animals; Blotting, Western; Cell Cycle; Cell Division; Chromatin; DNA; DNA-Binding Proteins; Drosophila; Gene Expression Regulation; Gene Silencing; Hela Cells; Humans; Models, Biological; Mutation; Neoplasms; Precipitin Tests; Proteins; RNA, Small Interfering; Repressor Proteins; Transcription Factors

PY - 2004

Y1 - 2004

N2 - Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.

AB - Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.

M3 - Journal article

C2 - 14752272

SN - 1538-4101

VL - 3

SP - 396

EP - 400

JO - Cell Cycle

JF - Cell Cycle

IS - 4

ER -