Polycomb group protein-mediated repression of transcription

Lluís Morey; Kristian Helin

doi:10.1016/j.tibs.2010.02.009

Polycomb group protein-mediated repression of transcription

Lluís Morey, Kristian Helin

273 Citations (Scopus)

Abstract

The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.

Original language	English
Journal	TIBS -Trends in Biochemical Sciences. Regular ed.
Volume	35
Issue number	6
Pages (from-to)	323-32
Number of pages	9
ISSN	0968-0004
DOIs	https://doi.org/10.1016/j.tibs.2010.02.009
Publication status	Published - Jun 2010

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title = "Polycomb group protein-mediated repression of transcription",

abstract = "The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.",

author = "Llu{\'i}s Morey and Kristian Helin",

note = "Keywords: Animals; Histones; Humans; Repressor Proteins; Response Elements; Transcription Factors; Transcription, Genetic",

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AU - Morey, Lluís

AU - Helin, Kristian

N1 - Keywords: Animals; Histones; Humans; Repressor Proteins; Response Elements; Transcription Factors; Transcription, Genetic

PY - 2010/6

Y1 - 2010/6

N2 - The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.

AB - The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.

U2 - 10.1016/j.tibs.2010.02.009

DO - 10.1016/j.tibs.2010.02.009

M3 - Journal article

C2 - 20346678

SN - 0968-0004

VL - 35

SP - 323

EP - 332

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 6

ER -

Polycomb group protein-mediated repression of transcription

Abstract

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