Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

Marianne Uhre Jakobsen; Claus Dethlefsen; Karen Margrete Due; Nadia Slimani; Veronique Chajès; Anne M May; Thorkild I A Sørensen; Jytte Halkjær; Anne Tjønneland; Francoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Guy Fagherazzi; Birgit Teucher; Rudolf Kaaks; Heiner Boeing; Madlen Schütze; Antonia Trichopoulou; Dimosthenis Zylis; George Makrygiannis; Domenico Palli; Amalia Mattiello; Giovanna Tagliabue; Daphne L van der; H B Bueno-de-Mesquita; Laudina Rodríguez; Noémie Travier; Esther Molina-Montes; José M Huerta; Aurelio Barricarte; Pilar Amiano; Jonas Manjer; Elisabet Wirfält; Ingegerd Johansson; Göran Hallmans; Kay-Tee Khaw; Nicholas J Wareham; Francesca Crowe; Isabelle Romieu; Elio Riboli; Petra H M Peeters; Kim Overvad

doi:10.1159/000330710

Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

Marianne Uhre Jakobsen, Claus Dethlefsen, Karen Margrete Due, Nadia Slimani, Veronique Chajès, Anne M May, Thorkild I A Sørensen, Jytte Halkjær, Anne Tjønneland, Francoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Birgit Teucher, Rudolf Kaaks, Heiner Boeing, Madlen Schütze, Antonia Trichopoulou, Dimosthenis Zylis, George Makrygiannis, Domenico PalliAmalia Mattiello, Giovanna Tagliabue, Daphne L van der, H B Bueno-de-Mesquita, Laudina Rodríguez, Noémie Travier, Esther Molina-Montes, José M Huerta, Aurelio Barricarte, Pilar Amiano, Jonas Manjer, Elisabet Wirfält, Ingegerd Johansson, Göran Hallmans, Kay-Tee Khaw, Nicholas J Wareham, Francesca Crowe, Isabelle Romieu, Elio Riboli, Petra H M Peeters, Kim Overvad

5 Citations (Scopus)

Abstract

Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.

Original language	English
Journal	Obesity Facts
Volume	4
Issue number	4
Pages (from-to)	312-8
Number of pages	7
ISSN	1662-4025
DOIs	https://doi.org/10.1159/000330710 https://doi.org/10.1159/000330710
Publication status	Published - Aug 2011

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Jakobsen, M. U., Dethlefsen, C., Due, K. M., Slimani, N., Chajès, V., May, A. M., Sørensen, T. I. A., Halkjær, J., Tjønneland, A., Clavel-Chapelon, F., Boutron-Ruault, M-C., Fagherazzi, G., Teucher, B., Kaaks, R., Boeing, H., Schütze, M., Trichopoulou, A., Zylis, D., Makrygiannis, G., ... Overvad, K. (2011). Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change. Obesity Facts, 4(4), 312-8. https://doi.org/10.1159/000330710, https://doi.org/10.1159/000330710

Jakobsen, MU, Dethlefsen, C, Due, KM, Slimani, N, Chajès, V, May, AM, Sørensen, TIA, Halkjær, J, Tjønneland, A, Clavel-Chapelon, F, Boutron-Ruault, M-C, Fagherazzi, G, Teucher, B, Kaaks, R, Boeing, H, Schütze, M, Trichopoulou, A, Zylis, D, Makrygiannis, G, Palli, D, Mattiello, A, Tagliabue, G, van der, DL, Bueno-de-Mesquita, HB, Rodríguez, L, Travier, N, Molina-Montes, E, Huerta, JM, Barricarte, A, Amiano, P, Manjer, J, Wirfält, E, Johansson, I, Hallmans, G, Khaw, K-T, Wareham, NJ, Crowe, F, Romieu, I, Riboli, E, Peeters, PHM & Overvad, K 2011, 'Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change', Obesity Facts, vol. 4, no. 4, pp. 312-8. https://doi.org/10.1159/000330710, https://doi.org/10.1159/000330710

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title = "Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change",

abstract = "Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.",

author = "Jakobsen, {Marianne Uhre} and Claus Dethlefsen and Due, {Karen Margrete} and Nadia Slimani and Veronique Chaj{\`e}s and May, {Anne M} and S{\o}rensen, {Thorkild I A} and Jytte Halkj{\ae}r and Anne Tj{\o}nneland and Francoise Clavel-Chapelon and Marie-Christine Boutron-Ruault and Guy Fagherazzi and Birgit Teucher and Rudolf Kaaks and Heiner Boeing and Madlen Sch{\"u}tze and Antonia Trichopoulou and Dimosthenis Zylis and George Makrygiannis and Domenico Palli and Amalia Mattiello and Giovanna Tagliabue and {van der}, {Daphne L} and Bueno-de-Mesquita, {H B} and Laudina Rodr{\'i}guez and No{\'e}mie Travier and Esther Molina-Montes and Huerta, {Jos{\'e} M} and Aurelio Barricarte and Pilar Amiano and Jonas Manjer and Elisabet Wirf{\"a}lt and Ingegerd Johansson and G{\"o}ran Hallmans and Kay-Tee Khaw and Wareham, {Nicholas J} and Francesca Crowe and Isabelle Romieu and Elio Riboli and Peeters, {Petra H M} and Kim Overvad",

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year = "2011",

month = aug,

doi = "10.1159/000330710",

language = "English",

volume = "4",

pages = "312--8",

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TY - JOUR

T1 - Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

AU - Jakobsen, Marianne Uhre

AU - Dethlefsen, Claus

AU - Due, Karen Margrete

AU - Slimani, Nadia

AU - Chajès, Veronique

AU - May, Anne M

AU - Sørensen, Thorkild I A

AU - Halkjær, Jytte

AU - Tjønneland, Anne

AU - Clavel-Chapelon, Francoise

AU - Boutron-Ruault, Marie-Christine

AU - Fagherazzi, Guy

AU - Teucher, Birgit

AU - Kaaks, Rudolf

AU - Boeing, Heiner

AU - Schütze, Madlen

AU - Trichopoulou, Antonia

AU - Zylis, Dimosthenis

AU - Makrygiannis, George

AU - Palli, Domenico

AU - Mattiello, Amalia

AU - Tagliabue, Giovanna

AU - van der, Daphne L

AU - Bueno-de-Mesquita, H B

AU - Rodríguez, Laudina

AU - Travier, Noémie

AU - Molina-Montes, Esther

AU - Huerta, José M

AU - Barricarte, Aurelio

AU - Amiano, Pilar

AU - Manjer, Jonas

AU - Wirfält, Elisabet

AU - Johansson, Ingegerd

AU - Hallmans, Göran

AU - Khaw, Kay-Tee

AU - Wareham, Nicholas J

AU - Crowe, Francesca

AU - Romieu, Isabelle

AU - Riboli, Elio

AU - Peeters, Petra H M

AU - Overvad, Kim

PY - 2011/8

Y1 - 2011/8

N2 - Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.

AB - Objective: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. Method: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. Results: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. Conclusion: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.

U2 - 10.1159/000330710

DO - 10.1159/000330710

M3 - Journal article

SN - 1662-4025

VL - 4

SP - 312

EP - 318

JO - Obesity Facts

JF - Obesity Facts

IS - 4

ER -

Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change

Abstract

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