Plasma and muscle myostatin in relation to type 2 diabetes

Claus Brandt; Anders R Nielsen; Christian P Fischer; Jakob Hansen; Bente K Pedersen; Peter Plomgaard

doi:10.1371/journal.pone.0037236

Plasma and muscle myostatin in relation to type 2 diabetes

Claus Brandt, Anders R Nielsen, Christian P Fischer, Jakob Hansen, Bente K Pedersen, Peter Plomgaard

68 Citations (Scopus)

Abstract

Objective: Myostatin is a secreted growth factor expressed in skeletal muscle tissue, which negatively regulates skeletal muscle mass. Recent animal studies suggest a role for myostatin in insulin resistance. We evaluated the possible metabolic role of myostatin in patients with type 2 diabetes and healthy controls. Design: 76 patients with type 2 diabetes and 92 control subjects were included in the study. They were matched for age, gender and BMI. Plasma samples and biopsies from the vastus lateralis muscle were obtained to assess plasma myostatin and expression of myostatin in skeletal muscle. Results: Patients with type 2 diabetes had higher fasting glucose (8.9 versus 5.1 mmol/L, P&0.001), plasma insulin (68.2 versus 47.2 pmol/L, P&0.002) and HOMA2-IR (1.6 versus 0.9, P&0.0001) when compared to controls. Patients with type 2 diabetes had 1.4 (P&0.01) higher levels of muscle myostatin mRNA content than the control subjects. Plasma myostatin concentrations did not differ between patients with type 2 diabetes and controls. In healthy controls, muscle myostatin mRNA correlated with HOMA2-IR (r = 0.30, P&0.01), plasma IL-6 (r = 0.34, P&0.05) and VO2 max (r = -0.26, P&0.05), however, no correlations were observed in patients with type 2 diabetes. Conclusions: This study supports the idea that myostatin may have a negative effect on metabolism. However, the metabolic effect of myostatin appears to be overruled by other factors in patients with type 2 diabetes.

Original language	English
Journal	P L o S One
Volume	7
Issue number	5
Pages (from-to)	e37236
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0037236
Publication status	Published - 16 May 2012

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title = "Plasma and muscle myostatin in relation to type 2 diabetes",

abstract = "Objective: Myostatin is a secreted growth factor expressed in skeletal muscle tissue, which negatively regulates skeletal muscle mass. Recent animal studies suggest a role for myostatin in insulin resistance. We evaluated the possible metabolic role of myostatin in patients with type 2 diabetes and healthy controls. Design: 76 patients with type 2 diabetes and 92 control subjects were included in the study. They were matched for age, gender and BMI. Plasma samples and biopsies from the vastus lateralis muscle were obtained to assess plasma myostatin and expression of myostatin in skeletal muscle. Results: Patients with type 2 diabetes had higher fasting glucose (8.9 versus 5.1 mmol/L, P&0.001), plasma insulin (68.2 versus 47.2 pmol/L, P&0.002) and HOMA2-IR (1.6 versus 0.9, P&0.0001) when compared to controls. Patients with type 2 diabetes had 1.4 (P&0.01) higher levels of muscle myostatin mRNA content than the control subjects. Plasma myostatin concentrations did not differ between patients with type 2 diabetes and controls. In healthy controls, muscle myostatin mRNA correlated with HOMA2-IR (r = 0.30, P&0.01), plasma IL-6 (r = 0.34, P&0.05) and VO2 max (r = -0.26, P&0.05), however, no correlations were observed in patients with type 2 diabetes. Conclusions: This study supports the idea that myostatin may have a negative effect on metabolism. However, the metabolic effect of myostatin appears to be overruled by other factors in patients with type 2 diabetes.",

author = "Claus Brandt and Nielsen, {Anders R} and Fischer, {Christian P} and Jakob Hansen and Pedersen, {Bente K} and Peter Plomgaard",

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T1 - Plasma and muscle myostatin in relation to type 2 diabetes

AU - Brandt, Claus

AU - Nielsen, Anders R

AU - Fischer, Christian P

AU - Hansen, Jakob

AU - Pedersen, Bente K

AU - Plomgaard, Peter

PY - 2012/5/16

Y1 - 2012/5/16

N2 - Objective: Myostatin is a secreted growth factor expressed in skeletal muscle tissue, which negatively regulates skeletal muscle mass. Recent animal studies suggest a role for myostatin in insulin resistance. We evaluated the possible metabolic role of myostatin in patients with type 2 diabetes and healthy controls. Design: 76 patients with type 2 diabetes and 92 control subjects were included in the study. They were matched for age, gender and BMI. Plasma samples and biopsies from the vastus lateralis muscle were obtained to assess plasma myostatin and expression of myostatin in skeletal muscle. Results: Patients with type 2 diabetes had higher fasting glucose (8.9 versus 5.1 mmol/L, P&0.001), plasma insulin (68.2 versus 47.2 pmol/L, P&0.002) and HOMA2-IR (1.6 versus 0.9, P&0.0001) when compared to controls. Patients with type 2 diabetes had 1.4 (P&0.01) higher levels of muscle myostatin mRNA content than the control subjects. Plasma myostatin concentrations did not differ between patients with type 2 diabetes and controls. In healthy controls, muscle myostatin mRNA correlated with HOMA2-IR (r = 0.30, P&0.01), plasma IL-6 (r = 0.34, P&0.05) and VO2 max (r = -0.26, P&0.05), however, no correlations were observed in patients with type 2 diabetes. Conclusions: This study supports the idea that myostatin may have a negative effect on metabolism. However, the metabolic effect of myostatin appears to be overruled by other factors in patients with type 2 diabetes.

AB - Objective: Myostatin is a secreted growth factor expressed in skeletal muscle tissue, which negatively regulates skeletal muscle mass. Recent animal studies suggest a role for myostatin in insulin resistance. We evaluated the possible metabolic role of myostatin in patients with type 2 diabetes and healthy controls. Design: 76 patients with type 2 diabetes and 92 control subjects were included in the study. They were matched for age, gender and BMI. Plasma samples and biopsies from the vastus lateralis muscle were obtained to assess plasma myostatin and expression of myostatin in skeletal muscle. Results: Patients with type 2 diabetes had higher fasting glucose (8.9 versus 5.1 mmol/L, P&0.001), plasma insulin (68.2 versus 47.2 pmol/L, P&0.002) and HOMA2-IR (1.6 versus 0.9, P&0.0001) when compared to controls. Patients with type 2 diabetes had 1.4 (P&0.01) higher levels of muscle myostatin mRNA content than the control subjects. Plasma myostatin concentrations did not differ between patients with type 2 diabetes and controls. In healthy controls, muscle myostatin mRNA correlated with HOMA2-IR (r = 0.30, P&0.01), plasma IL-6 (r = 0.34, P&0.05) and VO2 max (r = -0.26, P&0.05), however, no correlations were observed in patients with type 2 diabetes. Conclusions: This study supports the idea that myostatin may have a negative effect on metabolism. However, the metabolic effect of myostatin appears to be overruled by other factors in patients with type 2 diabetes.

U2 - 10.1371/journal.pone.0037236

DO - 10.1371/journal.pone.0037236

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JO - PLoS Computational Biology

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IS - 5

ER -

Plasma and muscle myostatin in relation to type 2 diabetes

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