Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Nina Føns Johnsen; Anne Tjønneland; Birthe L R Thomsen; Jane Christensen; Steffen Loft; Christine Friedenreich; Timothy J Key; Naomi E Allen; Petra H Lahmann; Lotte Mejlvig; Kim Overvad; Rudolf Kaaks; Sabine Rohrmann; Heiner Boing; Gesthimani Misirli; Antonia Trichopoulou; Dimosthenis Zylis; Rosario Tumino; Valeria Pala; H Bas Bueno-de-Mesquita; Lambertus A Kiemeney; Laudina Rodríguez Suárez; Carlos A Gonzalez; Maria-José Sánchez; José María Huerta; Aurelio Barricarte Gurrea; Jonas Manjer; Elisabet Wirfält; Kay-Tee Khaw; Nick Wareham; Paolo Boffetta; Lars Egevad; Sabina Rinaldi; Elio Riboli

doi:10.1002/ijc.24326

Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Nina Føns Johnsen, Anne Tjønneland, Birthe L R Thomsen, Jane Christensen, Steffen Loft, Christine Friedenreich, Timothy J Key, Naomi E Allen, Petra H Lahmann, Lotte Mejlvig, Kim Overvad, Rudolf Kaaks, Sabine Rohrmann, Heiner Boing, Gesthimani Misirli, Antonia Trichopoulou, Dimosthenis Zylis, Rosario Tumino, Valeria Pala, H Bas Bueno-de-MesquitaLambertus A Kiemeney, Laudina Rodríguez Suárez, Carlos A Gonzalez, Maria-José Sánchez, José María Huerta, Aurelio Barricarte Gurrea, Jonas Manjer, Elisabet Wirfält, Kay-Tee Khaw, Nick Wareham, Paolo Boffetta, Lars Egevad, Sabina Rinaldi, Elio Riboli

59 Citations (Scopus)

Abstract

The evidence concerning the possible association between physical activity and the risk of prostate cancer is inconsistent and additional data are needed. We examined the association between risk of prostate cancer and physical activity at work and in leisure time in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In our study, including 127,923 men aged 20-97 years from 8 European countries, 2,458 cases of prostate cancer were identified during 8.5 years of followup. Using the Cox proportional hazards model, we investigated the associations between prostate cancer incidence rate and occupational activity and leisure time activity in terms of participation in sports, cycling, walking and gardening; a metabolic equivalent (MET) score based on weekly time spent on the 4 activities; and a physical activity index. MET hours per week of leisure time activity, higher score in the physical activity index, participation in any of the 4 leisure time activities, and the number of leisure time activities in which the participants were active were not associated with prostate cancer incidence. However, higher level of occupational physical activity was associated with lower risk of advanced stage prostate cancer (p(trend) = 0.024). In conclusion, our data support the hypothesis of an inverse association between advanced prostate cancer risk and occupational physical activity, but we found no support for an association between prostate cancer risk and leisure time physical activity. (c) 2009 UICC.

Original language	English
Journal	International Journal of Cancer
Volume	125
Issue number	4
Pages (from-to)	902-908
Number of pages	6
ISSN	0020-7136
DOIs	https://doi.org/10.1002/ijc.24326
Publication status	Published - 2009

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Johnsen, N. F., Tjønneland, A., Thomsen, B. L. R., Christensen, J., Loft, S., Friedenreich, C., Key, T. J., Allen, N. E., Lahmann, P. H., Mejlvig, L., Overvad, K., Kaaks, R., Rohrmann, S., Boing, H., Misirli, G., Trichopoulou, A., Zylis, D., Tumino, R., Pala, V., ... Riboli, E. (2009). Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. International Journal of Cancer, 125(4), 902-908. https://doi.org/10.1002/ijc.24326

Johnsen, NF, Tjønneland, A, Thomsen, BLR, Christensen, J, Loft, S, Friedenreich, C, Key, TJ, Allen, NE, Lahmann, PH, Mejlvig, L, Overvad, K, Kaaks, R, Rohrmann, S, Boing, H, Misirli, G, Trichopoulou, A, Zylis, D, Tumino, R, Pala, V, Bueno-de-Mesquita, HB, Kiemeney, LA, Suárez, LR, Gonzalez, CA, Sánchez, M-J, Huerta, JM, Gurrea, AB, Manjer, J, Wirfält, E, Khaw, K-T, Wareham, N, Boffetta, P, Egevad, L, Rinaldi, S & Riboli, E 2009, 'Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort', International Journal of Cancer, vol. 125, no. 4, pp. 902-908. https://doi.org/10.1002/ijc.24326

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title = "Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort",

abstract = "The evidence concerning the possible association between physical activity and the risk of prostate cancer is inconsistent and additional data are needed. We examined the association between risk of prostate cancer and physical activity at work and in leisure time in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In our study, including 127,923 men aged 20-97 years from 8 European countries, 2,458 cases of prostate cancer were identified during 8.5 years of followup. Using the Cox proportional hazards model, we investigated the associations between prostate cancer incidence rate and occupational activity and leisure time activity in terms of participation in sports, cycling, walking and gardening; a metabolic equivalent (MET) score based on weekly time spent on the 4 activities; and a physical activity index. MET hours per week of leisure time activity, higher score in the physical activity index, participation in any of the 4 leisure time activities, and the number of leisure time activities in which the participants were active were not associated with prostate cancer incidence. However, higher level of occupational physical activity was associated with lower risk of advanced stage prostate cancer (p(trend) = 0.024). In conclusion, our data support the hypothesis of an inverse association between advanced prostate cancer risk and occupational physical activity, but we found no support for an association between prostate cancer risk and leisure time physical activity. (c) 2009 UICC.",

author = "Johnsen, {Nina F{\o}ns} and Anne Tj{\o}nneland and Thomsen, {Birthe L R} and Jane Christensen and Steffen Loft and Christine Friedenreich and Key, {Timothy J} and Allen, {Naomi E} and Lahmann, {Petra H} and Lotte Mejlvig and Kim Overvad and Rudolf Kaaks and Sabine Rohrmann and Heiner Boing and Gesthimani Misirli and Antonia Trichopoulou and Dimosthenis Zylis and Rosario Tumino and Valeria Pala and Bueno-de-Mesquita, {H Bas} and Kiemeney, {Lambertus A} and Su{\'a}rez, {Laudina Rodr{\'i}guez} and Gonzalez, {Carlos A} and Maria-Jos{\'e} S{\'a}nchez and Huerta, {Jos{\'e} Mar{\'i}a} and Gurrea, {Aurelio Barricarte} and Jonas Manjer and Elisabet Wirf{\"a}lt and Kay-Tee Khaw and Nick Wareham and Paolo Boffetta and Lars Egevad and Sabina Rinaldi and Elio Riboli",

year = "2009",

doi = "10.1002/ijc.24326",

language = "English",

volume = "125",

pages = "902--908",

journal = "Radiation Oncology Investigations",

issn = "0020-7136",

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TY - JOUR

T1 - Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

AU - Johnsen, Nina Føns

AU - Tjønneland, Anne

AU - Thomsen, Birthe L R

AU - Christensen, Jane

AU - Loft, Steffen

AU - Friedenreich, Christine

AU - Key, Timothy J

AU - Allen, Naomi E

AU - Lahmann, Petra H

AU - Mejlvig, Lotte

AU - Overvad, Kim

AU - Kaaks, Rudolf

AU - Rohrmann, Sabine

AU - Boing, Heiner

AU - Misirli, Gesthimani

AU - Trichopoulou, Antonia

AU - Zylis, Dimosthenis

AU - Tumino, Rosario

AU - Pala, Valeria

AU - Bueno-de-Mesquita, H Bas

AU - Kiemeney, Lambertus A

AU - Suárez, Laudina Rodríguez

AU - Gonzalez, Carlos A

AU - Sánchez, Maria-José

AU - Huerta, José María

AU - Gurrea, Aurelio Barricarte

AU - Manjer, Jonas

AU - Wirfält, Elisabet

AU - Khaw, Kay-Tee

AU - Wareham, Nick

AU - Boffetta, Paolo

AU - Egevad, Lars

AU - Rinaldi, Sabina

AU - Riboli, Elio

PY - 2009

Y1 - 2009

N2 - The evidence concerning the possible association between physical activity and the risk of prostate cancer is inconsistent and additional data are needed. We examined the association between risk of prostate cancer and physical activity at work and in leisure time in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In our study, including 127,923 men aged 20-97 years from 8 European countries, 2,458 cases of prostate cancer were identified during 8.5 years of followup. Using the Cox proportional hazards model, we investigated the associations between prostate cancer incidence rate and occupational activity and leisure time activity in terms of participation in sports, cycling, walking and gardening; a metabolic equivalent (MET) score based on weekly time spent on the 4 activities; and a physical activity index. MET hours per week of leisure time activity, higher score in the physical activity index, participation in any of the 4 leisure time activities, and the number of leisure time activities in which the participants were active were not associated with prostate cancer incidence. However, higher level of occupational physical activity was associated with lower risk of advanced stage prostate cancer (p(trend) = 0.024). In conclusion, our data support the hypothesis of an inverse association between advanced prostate cancer risk and occupational physical activity, but we found no support for an association between prostate cancer risk and leisure time physical activity. (c) 2009 UICC.

AB - The evidence concerning the possible association between physical activity and the risk of prostate cancer is inconsistent and additional data are needed. We examined the association between risk of prostate cancer and physical activity at work and in leisure time in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In our study, including 127,923 men aged 20-97 years from 8 European countries, 2,458 cases of prostate cancer were identified during 8.5 years of followup. Using the Cox proportional hazards model, we investigated the associations between prostate cancer incidence rate and occupational activity and leisure time activity in terms of participation in sports, cycling, walking and gardening; a metabolic equivalent (MET) score based on weekly time spent on the 4 activities; and a physical activity index. MET hours per week of leisure time activity, higher score in the physical activity index, participation in any of the 4 leisure time activities, and the number of leisure time activities in which the participants were active were not associated with prostate cancer incidence. However, higher level of occupational physical activity was associated with lower risk of advanced stage prostate cancer (p(trend) = 0.024). In conclusion, our data support the hypothesis of an inverse association between advanced prostate cancer risk and occupational physical activity, but we found no support for an association between prostate cancer risk and leisure time physical activity. (c) 2009 UICC.

U2 - 10.1002/ijc.24326

DO - 10.1002/ijc.24326

M3 - Journal article

C2 - 19415749

SN - 0020-7136

VL - 125

SP - 902

EP - 908

JO - Radiation Oncology Investigations

JF - Radiation Oncology Investigations

IS - 4

ER -

Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Abstract

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