Phthalates, perfluoroalkyl acids, metals and organochlorines and reproductive function: a multipollutant assessment in Greenlandic, Polish and Ukrainian men

Virissa Lenters; Lützen Portengen; Lidwien A M Smit; Bo A G Jönsson; Aleksander Giwercman; Lars Rylander; Christian H Lindh; Marcello Spanò; Henning S Pedersen; Jan K Ludwicki; Lyubov Chumak; Aldert H Piersma; Gunnar Toft; Jens Peter Bonde; Dick Heederik; Roel Vermeulen

doi:10.1136/oemed-2014-102264

Phthalates, perfluoroalkyl acids, metals and organochlorines and reproductive function: a multipollutant assessment in Greenlandic, Polish and Ukrainian men

Virissa Lenters, Lützen Portengen, Lidwien A M Smit, Bo A G Jönsson, Aleksander Giwercman, Lars Rylander, Christian H Lindh, Marcello Spanò, Henning S Pedersen, Jan K Ludwicki, Lyubov Chumak, Aldert H Piersma, Gunnar Toft, Jens Peter Bonde, Dick Heederik, Roel Vermeulen

Department of Public Health

40 Citations (Scopus)

Abstract

OBJECTIVES: Numerous environmental contaminants have been linked to adverse reproductive health outcomes. However, the complex correlation structure of exposures and multiple testing issues limit the interpretation of existing evidence. Our objective was to identify, from a large set of contaminant exposures, exposure profiles associated with biomarkers of male reproductive function.

METHODS: In this cross-sectional study (n=602), male partners of pregnant women were enrolled between 2002 and 2004 during antenatal care visits in Greenland, Poland and Ukraine. Fifteen contaminants were detected in more than 70% of blood samples, including metabolites of di(2-ethylhexyl) and diisononyl phthalates (DEHP, DiNP), perfluoroalkyl acids, metals and organochlorines. Twenty-two reproductive biomarkers were assessed, including serum levels of reproductive hormones, markers of semen quality, sperm chromatin integrity, epididymal and accessory sex gland function, and Y:X chromosome ratio. We evaluated multipollutant models with sparse partial least squares (sPLS) regression, a simultaneous dimension reduction and variable selection approach which accommodates joint modelling of correlated exposures.

RESULTS: Of the over 300 exposure-outcome associations tested in sPLS models, we detected 10 associations encompassing 8 outcomes. Several associations were notably consistent in direction across the three study populations: positive associations between mercury and inhibin B, and between cadmium and testosterone; and inverse associations between DiNP metabolites and testosterone, between polychlorinated biphenyl-153 and progressive sperm motility, and between a DEHP metabolite and neutral α-glucosidase, a marker of epididymal function.

CONCLUSIONS: This global assessment of a mixture of environmental contaminants provides further indications that some organochlorines and phthalates adversely affect some parameters of male reproductive health.

Original language	English
Journal	Occupational and Environmental Medicine
Volume	72
Issue number	6
Pages (from-to)	385-393
Number of pages	9
ISSN	1351-0711
DOIs	https://doi.org/10.1136/oemed-2014-102264
Publication status	Published - 1 Jun 2015

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Lenters, V., Portengen, L., Smit, L. A. M., Jönsson, B. A. G., Giwercman, A., Rylander, L., Lindh, C. H., Spanò, M., Pedersen, H. S., Ludwicki, J. K., Chumak, L., Piersma, A. H., Toft, G., Bonde, J. P., Heederik, D., & Vermeulen, R. (2015). Phthalates, perfluoroalkyl acids, metals and organochlorines and reproductive function: a multipollutant assessment in Greenlandic, Polish and Ukrainian men. Occupational and Environmental Medicine, 72(6), 385-393. https://doi.org/10.1136/oemed-2014-102264

Phthalates, perfluoroalkyl acids, metals and organochlorines and reproductive function : a multipollutant assessment in Greenlandic, Polish and Ukrainian men. / Lenters, Virissa; Portengen, Lützen; Smit, Lidwien A M et al.

In: Occupational and Environmental Medicine, Vol. 72, No. 6, 01.06.2015, p. 385-393.

Research output: Contribution to journal › Journal article › Research › peer-review

Lenters, V, Portengen, L, Smit, LAM, Jönsson, BAG, Giwercman, A, Rylander, L, Lindh, CH, Spanò, M, Pedersen, HS, Ludwicki, JK, Chumak, L, Piersma, AH, Toft, G, Bonde, JP, Heederik, D & Vermeulen, R 2015, 'Phthalates, perfluoroalkyl acids, metals and organochlorines and reproductive function: a multipollutant assessment in Greenlandic, Polish and Ukrainian men', Occupational and Environmental Medicine, vol. 72, no. 6, pp. 385-393. https://doi.org/10.1136/oemed-2014-102264

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abstract = "OBJECTIVES: Numerous environmental contaminants have been linked to adverse reproductive health outcomes. However, the complex correlation structure of exposures and multiple testing issues limit the interpretation of existing evidence. Our objective was to identify, from a large set of contaminant exposures, exposure profiles associated with biomarkers of male reproductive function.METHODS: In this cross-sectional study (n=602), male partners of pregnant women were enrolled between 2002 and 2004 during antenatal care visits in Greenland, Poland and Ukraine. Fifteen contaminants were detected in more than 70% of blood samples, including metabolites of di(2-ethylhexyl) and diisononyl phthalates (DEHP, DiNP), perfluoroalkyl acids, metals and organochlorines. Twenty-two reproductive biomarkers were assessed, including serum levels of reproductive hormones, markers of semen quality, sperm chromatin integrity, epididymal and accessory sex gland function, and Y:X chromosome ratio. We evaluated multipollutant models with sparse partial least squares (sPLS) regression, a simultaneous dimension reduction and variable selection approach which accommodates joint modelling of correlated exposures.RESULTS: Of the over 300 exposure-outcome associations tested in sPLS models, we detected 10 associations encompassing 8 outcomes. Several associations were notably consistent in direction across the three study populations: positive associations between mercury and inhibin B, and between cadmium and testosterone; and inverse associations between DiNP metabolites and testosterone, between polychlorinated biphenyl-153 and progressive sperm motility, and between a DEHP metabolite and neutral α-glucosidase, a marker of epididymal function.CONCLUSIONS: This global assessment of a mixture of environmental contaminants provides further indications that some organochlorines and phthalates adversely affect some parameters of male reproductive health.",

author = "Virissa Lenters and L{\"u}tzen Portengen and Smit, {Lidwien A M} and J{\"o}nsson, {Bo A G} and Aleksander Giwercman and Lars Rylander and Lindh, {Christian H} and Marcello Span{\`o} and Pedersen, {Henning S} and Ludwicki, {Jan K} and Lyubov Chumak and Piersma, {Aldert H} and Gunnar Toft and Bonde, {Jens Peter} and Dick Heederik and Roel Vermeulen",

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T1 - Phthalates, perfluoroalkyl acids, metals and organochlorines and reproductive function

T2 - a multipollutant assessment in Greenlandic, Polish and Ukrainian men

AU - Lenters, Virissa

AU - Portengen, Lützen

AU - Smit, Lidwien A M

AU - Jönsson, Bo A G

AU - Giwercman, Aleksander

AU - Rylander, Lars

AU - Lindh, Christian H

AU - Spanò, Marcello

AU - Pedersen, Henning S

AU - Ludwicki, Jan K

AU - Chumak, Lyubov

AU - Piersma, Aldert H

AU - Toft, Gunnar

AU - Bonde, Jens Peter

AU - Heederik, Dick

AU - Vermeulen, Roel

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - OBJECTIVES: Numerous environmental contaminants have been linked to adverse reproductive health outcomes. However, the complex correlation structure of exposures and multiple testing issues limit the interpretation of existing evidence. Our objective was to identify, from a large set of contaminant exposures, exposure profiles associated with biomarkers of male reproductive function.METHODS: In this cross-sectional study (n=602), male partners of pregnant women were enrolled between 2002 and 2004 during antenatal care visits in Greenland, Poland and Ukraine. Fifteen contaminants were detected in more than 70% of blood samples, including metabolites of di(2-ethylhexyl) and diisononyl phthalates (DEHP, DiNP), perfluoroalkyl acids, metals and organochlorines. Twenty-two reproductive biomarkers were assessed, including serum levels of reproductive hormones, markers of semen quality, sperm chromatin integrity, epididymal and accessory sex gland function, and Y:X chromosome ratio. We evaluated multipollutant models with sparse partial least squares (sPLS) regression, a simultaneous dimension reduction and variable selection approach which accommodates joint modelling of correlated exposures.RESULTS: Of the over 300 exposure-outcome associations tested in sPLS models, we detected 10 associations encompassing 8 outcomes. Several associations were notably consistent in direction across the three study populations: positive associations between mercury and inhibin B, and between cadmium and testosterone; and inverse associations between DiNP metabolites and testosterone, between polychlorinated biphenyl-153 and progressive sperm motility, and between a DEHP metabolite and neutral α-glucosidase, a marker of epididymal function.CONCLUSIONS: This global assessment of a mixture of environmental contaminants provides further indications that some organochlorines and phthalates adversely affect some parameters of male reproductive health.

AB - OBJECTIVES: Numerous environmental contaminants have been linked to adverse reproductive health outcomes. However, the complex correlation structure of exposures and multiple testing issues limit the interpretation of existing evidence. Our objective was to identify, from a large set of contaminant exposures, exposure profiles associated with biomarkers of male reproductive function.METHODS: In this cross-sectional study (n=602), male partners of pregnant women were enrolled between 2002 and 2004 during antenatal care visits in Greenland, Poland and Ukraine. Fifteen contaminants were detected in more than 70% of blood samples, including metabolites of di(2-ethylhexyl) and diisononyl phthalates (DEHP, DiNP), perfluoroalkyl acids, metals and organochlorines. Twenty-two reproductive biomarkers were assessed, including serum levels of reproductive hormones, markers of semen quality, sperm chromatin integrity, epididymal and accessory sex gland function, and Y:X chromosome ratio. We evaluated multipollutant models with sparse partial least squares (sPLS) regression, a simultaneous dimension reduction and variable selection approach which accommodates joint modelling of correlated exposures.RESULTS: Of the over 300 exposure-outcome associations tested in sPLS models, we detected 10 associations encompassing 8 outcomes. Several associations were notably consistent in direction across the three study populations: positive associations between mercury and inhibin B, and between cadmium and testosterone; and inverse associations between DiNP metabolites and testosterone, between polychlorinated biphenyl-153 and progressive sperm motility, and between a DEHP metabolite and neutral α-glucosidase, a marker of epididymal function.CONCLUSIONS: This global assessment of a mixture of environmental contaminants provides further indications that some organochlorines and phthalates adversely affect some parameters of male reproductive health.

U2 - 10.1136/oemed-2014-102264

DO - 10.1136/oemed-2014-102264

M3 - Journal article

C2 - 25209848

SN - 1351-0711

VL - 72

SP - 385

EP - 393

JO - Occupational and Environmental Medicine

JF - Occupational and Environmental Medicine

IS - 6

ER -

Phthalates, perfluoroalkyl acids, metals and organochlorines and reproductive function: a multipollutant assessment in Greenlandic, Polish and Ukrainian men

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