Abstract
Myocardial ischemia-reperfusion injury is a clinical challenge in interventional cardiology, and at the moment, no pharmacological agent is universally accepted in the prevention. In order to prevent inappropriate clinical trials, a potential pharmacological agent should be proved reproducibly effective in clinically relevant experimental studies before initiation of human studies. The closed-chest porcine model is a promising experimental model of ischemia-reperfusion injury. The purpose of this systematic review was to describe the pharmacological treatments evaluated in the closed-chest porcine model and discuss different aspects of the model for future use. The systematic review was performed according to the PRISMA guidelines.
| Original language | English |
|---|---|
| Journal | Journal of Cardiovascular Translational Research |
| Volume | 7 |
| Issue number | 6 |
| Pages (from-to) | 570-580 |
| Number of pages | 11 |
| ISSN | 1937-5387 |
| DOIs | |
| Publication status | Published - Aug 2014 |
Keywords
- Animals
- Cardiovascular Agents
- Disease Models, Animal
- Myocardial Reperfusion Injury
- Swine
- Treatment Outcome