Perinatal Risk Factors for Feeding and Eating Disorders in Children Aged 0 to 3 Years

Carolina Hvelplund; Bo Mølholm Hansen; Susanne Vinkel Koch; Mikael Andersson; Anne Mette Skovgaard

doi:10.1542/peds.2015-2575

Perinatal Risk Factors for Feeding and Eating Disorders in Children Aged 0 to 3 Years

Carolina Hvelplund, Bo Mølholm Hansen, Susanne Vinkel Koch, Mikael Andersson, Anne Mette Skovgaard

8 Citations (Scopus)

Abstract

OBJECTIVE: To describe the incidence, age at diagnosis, and associations between perinatal risk factors of feeding and eating disorders (FED) diagnosed at hospital in children aged 0 to 3 years.

METHODS: A nationwide cohort of 901 227 children was followed until 48 months of age in the national registers from 1997 to 2010. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HRs) for FED diagnosis according to the International Classification of Diseases and associations with perinatal risk factors.

RESULTS: A total of 1365 children (53% girls) were diagnosed with FED at hospital, corresponding to a cumulative incidence of 1.6 per 1000 live births. High risk of FED was seen in children born before gestational week 28 (HR, 3.52; 95% confidence interval [CI], 2.15-5.78). HRs were 3.74 for children small for gestational age ≤3 SD (95% CI, 2.71-5.17) and 4.71 in those with congenital malformations (95% CI, 3.86-5.74). Increased risk of FED was associated with female gender (HR, 1.2; 95% CI, 1.08-1.34), maternal smoking in pregnancy (HR, 1.24; 95% CI, 1.08-1.42), immigrant status (HR, 2.24; 95% CI, 1.92-2.61), and being the firstborn (HR, 1.33; 95% CI, 1.19-1.50).

CONCLUSIONS: FED in referred children aged 0 to 3 years are associated with perinatal adversities, female gender, maternal smoking in pregnancy, being firstborn, and having immigrant parents. The results suggest complex causal mechanisms of FED and underscore the need for a multidisciplinary approach in the clinical management of young children with persistent problems of feeding, eating, and weight faltering.

Original language	English
Article number	e20152575
Journal	Pediatrics
Volume	137
Issue number	2
Number of pages	8
ISSN	0031-4005
DOIs	https://doi.org/10.1542/peds.2015-2575
Publication status	Published - Feb 2016

Keywords

Adult
Child, Preschool
Denmark
Emigrants and Immigrants
Feeding and Eating Disorders
Female
Follow-Up Studies
Humans
Incidence
Infant
Infant, Newborn
Male
Maternal Age
Middle Aged
Pregnancy
Prenatal Exposure Delayed Effects
Proportional Hazards Models
Registries
Risk Factors
Sex Factors
Journal Article
Research Support, Non-U.S. Gov't

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10.1542/peds.2015-2575

https://pediatrics.aappublications.org/content/pediatrics/137/2/e20152575.full.pdf

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@article{9d9e77d08a9c4b6c88fe12bab59b3277,

title = "Perinatal Risk Factors for Feeding and Eating Disorders in Children Aged 0 to 3 Years",

abstract = "OBJECTIVE: To describe the incidence, age at diagnosis, and associations between perinatal risk factors of feeding and eating disorders (FED) diagnosed at hospital in children aged 0 to 3 years.METHODS: A nationwide cohort of 901 227 children was followed until 48 months of age in the national registers from 1997 to 2010. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HRs) for FED diagnosis according to the International Classification of Diseases and associations with perinatal risk factors.RESULTS: A total of 1365 children (53% girls) were diagnosed with FED at hospital, corresponding to a cumulative incidence of 1.6 per 1000 live births. High risk of FED was seen in children born before gestational week 28 (HR, 3.52; 95% confidence interval [CI], 2.15-5.78). HRs were 3.74 for children small for gestational age ≤3 SD (95% CI, 2.71-5.17) and 4.71 in those with congenital malformations (95% CI, 3.86-5.74). Increased risk of FED was associated with female gender (HR, 1.2; 95% CI, 1.08-1.34), maternal smoking in pregnancy (HR, 1.24; 95% CI, 1.08-1.42), immigrant status (HR, 2.24; 95% CI, 1.92-2.61), and being the firstborn (HR, 1.33; 95% CI, 1.19-1.50).CONCLUSIONS: FED in referred children aged 0 to 3 years are associated with perinatal adversities, female gender, maternal smoking in pregnancy, being firstborn, and having immigrant parents. The results suggest complex causal mechanisms of FED and underscore the need for a multidisciplinary approach in the clinical management of young children with persistent problems of feeding, eating, and weight faltering.",

keywords = "Adult, Child, Preschool, Denmark, Emigrants and Immigrants, Feeding and Eating Disorders, Female, Follow-Up Studies, Humans, Incidence, Infant, Infant, Newborn, Male, Maternal Age, Middle Aged, Pregnancy, Prenatal Exposure Delayed Effects, Proportional Hazards Models, Registries, Risk Factors, Sex Factors, Journal Article, Research Support, Non-U.S. Gov't",

author = "Carolina Hvelplund and Hansen, {Bo M{\o}lholm} and Koch, {Susanne Vinkel} and Mikael Andersson and Skovgaard, {Anne Mette}",

note = "Copyright {\textcopyright} 2016 by the American Academy of Pediatrics.",

year = "2016",

month = feb,

doi = "10.1542/peds.2015-2575",

language = "English",

volume = "137",

journal = "Pediatrics",

issn = "0031-4005",

publisher = "American Academy of Pediatrics",

number = "2",

}

TY - JOUR

T1 - Perinatal Risk Factors for Feeding and Eating Disorders in Children Aged 0 to 3 Years

AU - Hvelplund, Carolina

AU - Hansen, Bo Mølholm

AU - Koch, Susanne Vinkel

AU - Andersson, Mikael

AU - Skovgaard, Anne Mette

PY - 2016/2

Y1 - 2016/2

N2 - OBJECTIVE: To describe the incidence, age at diagnosis, and associations between perinatal risk factors of feeding and eating disorders (FED) diagnosed at hospital in children aged 0 to 3 years.METHODS: A nationwide cohort of 901 227 children was followed until 48 months of age in the national registers from 1997 to 2010. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HRs) for FED diagnosis according to the International Classification of Diseases and associations with perinatal risk factors.RESULTS: A total of 1365 children (53% girls) were diagnosed with FED at hospital, corresponding to a cumulative incidence of 1.6 per 1000 live births. High risk of FED was seen in children born before gestational week 28 (HR, 3.52; 95% confidence interval [CI], 2.15-5.78). HRs were 3.74 for children small for gestational age ≤3 SD (95% CI, 2.71-5.17) and 4.71 in those with congenital malformations (95% CI, 3.86-5.74). Increased risk of FED was associated with female gender (HR, 1.2; 95% CI, 1.08-1.34), maternal smoking in pregnancy (HR, 1.24; 95% CI, 1.08-1.42), immigrant status (HR, 2.24; 95% CI, 1.92-2.61), and being the firstborn (HR, 1.33; 95% CI, 1.19-1.50).CONCLUSIONS: FED in referred children aged 0 to 3 years are associated with perinatal adversities, female gender, maternal smoking in pregnancy, being firstborn, and having immigrant parents. The results suggest complex causal mechanisms of FED and underscore the need for a multidisciplinary approach in the clinical management of young children with persistent problems of feeding, eating, and weight faltering.

AB - OBJECTIVE: To describe the incidence, age at diagnosis, and associations between perinatal risk factors of feeding and eating disorders (FED) diagnosed at hospital in children aged 0 to 3 years.METHODS: A nationwide cohort of 901 227 children was followed until 48 months of age in the national registers from 1997 to 2010. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HRs) for FED diagnosis according to the International Classification of Diseases and associations with perinatal risk factors.RESULTS: A total of 1365 children (53% girls) were diagnosed with FED at hospital, corresponding to a cumulative incidence of 1.6 per 1000 live births. High risk of FED was seen in children born before gestational week 28 (HR, 3.52; 95% confidence interval [CI], 2.15-5.78). HRs were 3.74 for children small for gestational age ≤3 SD (95% CI, 2.71-5.17) and 4.71 in those with congenital malformations (95% CI, 3.86-5.74). Increased risk of FED was associated with female gender (HR, 1.2; 95% CI, 1.08-1.34), maternal smoking in pregnancy (HR, 1.24; 95% CI, 1.08-1.42), immigrant status (HR, 2.24; 95% CI, 1.92-2.61), and being the firstborn (HR, 1.33; 95% CI, 1.19-1.50).CONCLUSIONS: FED in referred children aged 0 to 3 years are associated with perinatal adversities, female gender, maternal smoking in pregnancy, being firstborn, and having immigrant parents. The results suggest complex causal mechanisms of FED and underscore the need for a multidisciplinary approach in the clinical management of young children with persistent problems of feeding, eating, and weight faltering.

KW - Adult

KW - Child, Preschool

KW - Denmark

KW - Emigrants and Immigrants

KW - Feeding and Eating Disorders

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Maternal Age

KW - Middle Aged

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects

KW - Proportional Hazards Models

KW - Registries

KW - Risk Factors

KW - Sex Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1542/peds.2015-2575

DO - 10.1542/peds.2015-2575

M3 - Journal article

C2 - 26764360

SN - 0031-4005

VL - 137

JO - Pediatrics

JF - Pediatrics

IS - 2

M1 - e20152575

ER -

Perinatal Risk Factors for Feeding and Eating Disorders in Children Aged 0 to 3 Years

Abstract

Keywords

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