Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes

Dorte M Jensen; Lars Korsholm; Per Ovesen; Henning Beck-Nielsen; Lars Moelsted-Pedersen; Jes G Westergaard; Margrethe Moeller; Peter Damm; Dorte Jensen; Lars Korsholm Lauridsen; Per Glud Ovesen; Henning Beck-Nielsen; Lars Moelsted-Pedersen; Jes G Westergaard; Margrethe Moeller; Peter Damm

doi:10.2337/dc08-2061

Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes

Dorte M Jensen, Lars Korsholm, Per Ovesen, Henning Beck-Nielsen, Lars Moelsted-Pedersen, Jes G Westergaard, Margrethe Moeller, Peter Damm, Dorte Jensen, Lars Korsholm Lauridsen, Per Glud Ovesen, Henning Beck-Nielsen, Lars Moelsted-Pedersen, Jes G Westergaard, Margrethe Moeller, Peter Damm

Faculty of Health and Medical Sciences

126 Citations (Scopus)

Abstract

OBJECTIVE: To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). RESEARCH DESIGN AND METHODS: Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS: The risk of serious adverse outcome at different A1C levels was compared with the background population. The risk was significantly higher when peri-conceptional A1C exceeded 6.9%, and the risk tended to increase gradually with increasing A1C. Women with A1C exceeding 10.4% had a very high risk of 16%. Congenital malformation rate increased significantly at A1C above 10.4%, whereas perinatal mortality was increased even at A1C below 6.9%. CONCLUSIONS: These results support recent guidelines of preconceptional A1C levels <7% in women with type 1 diabetes.

Original language	English
Journal	Diabetes Care
Volume	32
Issue number	6
Pages (from-to)	1046-8
Number of pages	3
ISSN	0149-5992
DOIs	https://doi.org/10.2337/dc08-2061 https://doi.org/10.2337/dc08-2061
Publication status	Published - 1 Jun 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

Cite this

Jensen, D. M., Korsholm, L., Ovesen, P., Beck-Nielsen, H., Moelsted-Pedersen, L., Westergaard, J. G., Moeller, M., Damm, P., Jensen, D., Lauridsen, L. K., Ovesen, P. G., Beck-Nielsen, H., Moelsted-Pedersen, L., Westergaard, J. G., Moeller, M., & Damm, P. (2009). Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes. Diabetes Care, 32(6), 1046-8. https://doi.org/10.2337/dc08-2061, https://doi.org/10.2337/dc08-2061

Jensen, DM, Korsholm, L, Ovesen, P, Beck-Nielsen, H, Moelsted-Pedersen, L, Westergaard, JG, Moeller, M, Damm, P, Jensen, D, Lauridsen, LK, Ovesen, PG, Beck-Nielsen, H, Moelsted-Pedersen, L, Westergaard, JG, Moeller, M & Damm, P 2009, 'Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes', Diabetes Care, vol. 32, no. 6, pp. 1046-8. https://doi.org/10.2337/dc08-2061, https://doi.org/10.2337/dc08-2061

@article{ea05b9e067f011df928f000ea68e967b,

title = "Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes",

abstract = "OBJECTIVE: To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). RESEARCH DESIGN AND METHODS: Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS: The risk of serious adverse outcome at different A1C levels was compared with the background population. The risk was significantly higher when peri-conceptional A1C exceeded 6.9%, and the risk tended to increase gradually with increasing A1C. Women with A1C exceeding 10.4% had a very high risk of 16%. Congenital malformation rate increased significantly at A1C above 10.4%, whereas perinatal mortality was increased even at A1C below 6.9%. CONCLUSIONS: These results support recent guidelines of preconceptional A1C levels <7% in women with type 1 diabetes.",

author = "Jensen, {Dorte M} and Lars Korsholm and Per Ovesen and Henning Beck-Nielsen and Lars Moelsted-Pedersen and Westergaard, {Jes G} and Margrethe Moeller and Peter Damm and Dorte Jensen and Lauridsen, {Lars Korsholm} and Ovesen, {Per Glud} and Henning Beck-Nielsen and Lars Moelsted-Pedersen and Westergaard, {Jes G} and Margrethe Moeller and Peter Damm",

note = "Keywords: Body Mass Index; Chromosome Aberrations; Diabetes Mellitus, Type 1; European Continental Ancestry Group; Female; Hemoglobin A, Glycosylated; Humans; Infant, Newborn; Perinatal Mortality; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prospective Studies; Retrospective Studies",

year = "2009",

month = jun,

day = "1",

doi = "10.2337/dc08-2061",

language = "English",

volume = "32",

pages = "1046--8",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "American Diabetes Association",

number = "6",

}

TY - JOUR

T1 - Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes

AU - Jensen, Dorte M

AU - Korsholm, Lars

AU - Ovesen, Per

AU - Beck-Nielsen, Henning

AU - Moelsted-Pedersen, Lars

AU - Westergaard, Jes G

AU - Moeller, Margrethe

AU - Damm, Peter

AU - Jensen, Dorte

AU - Lauridsen, Lars Korsholm

AU - Ovesen, Per Glud

AU - Beck-Nielsen, Henning

AU - Moelsted-Pedersen, Lars

AU - Westergaard, Jes G

AU - Moeller, Margrethe

AU - Damm, Peter

N1 - Keywords: Body Mass Index; Chromosome Aberrations; Diabetes Mellitus, Type 1; European Continental Ancestry Group; Female; Hemoglobin A, Glycosylated; Humans; Infant, Newborn; Perinatal Mortality; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prospective Studies; Retrospective Studies

PY - 2009/6/1

Y1 - 2009/6/1

N2 - OBJECTIVE: To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). RESEARCH DESIGN AND METHODS: Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS: The risk of serious adverse outcome at different A1C levels was compared with the background population. The risk was significantly higher when peri-conceptional A1C exceeded 6.9%, and the risk tended to increase gradually with increasing A1C. Women with A1C exceeding 10.4% had a very high risk of 16%. Congenital malformation rate increased significantly at A1C above 10.4%, whereas perinatal mortality was increased even at A1C below 6.9%. CONCLUSIONS: These results support recent guidelines of preconceptional A1C levels <7% in women with type 1 diabetes.

AB - OBJECTIVE: To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). RESEARCH DESIGN AND METHODS: Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS: The risk of serious adverse outcome at different A1C levels was compared with the background population. The risk was significantly higher when peri-conceptional A1C exceeded 6.9%, and the risk tended to increase gradually with increasing A1C. Women with A1C exceeding 10.4% had a very high risk of 16%. Congenital malformation rate increased significantly at A1C above 10.4%, whereas perinatal mortality was increased even at A1C below 6.9%. CONCLUSIONS: These results support recent guidelines of preconceptional A1C levels <7% in women with type 1 diabetes.

U2 - 10.2337/dc08-2061

DO - 10.2337/dc08-2061

M3 - Journal article

C2 - 19265024

SN - 0149-5992

VL - 32

SP - 1046

EP - 1048

JO - Diabetes Care

JF - Diabetes Care

IS - 6

ER -

Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this