Perceived job insecurity as a risk factor for incident coronary heart disease: systematic review and meta-analysis

Marianna Virtanen; Solja T Nyberg; George David Batty; Markus Jokela; Katriina Heikkilä; Eleonor I Fransson; Lars Alfredsson; Jakob B Bjorner; Marianne Borritz; Hermann Burr; Annalisa Casini; Els Clays; Dirk De Bacquer; Nico Dragano; Marko Elovainio; Raimund Erbel; Jane E Ferrie; Mark Hamer; Karl-Heinz Jöckel; France Kittel; Anders Knutsson; Markku Koskenvuo; Aki Koskinen; Thorsten Lunau; Ida Elisabeth Huitfeldt Madsen; Martin L Nielsen; Maria Nordin; Tuula Oksanen; Krista Pahkin; Jan Pejtersen; Jaana Pentti; Reiner Ernst Rugulies; Paula Salo; Martin J Shipley; Johannes Siegrist; Andrew Steptoe; Sakari B Suominen; Töres Theorell; Salla Toppinen-Tanner; Ari Väänänen; Jussi Vahtera; Peter J M Westerholm; Hugo Westerlund; Natalie Slopen; Ichiro Kawachi; Archana Singh-Manoux; Mika Kivimäki; IPD-Work Consortium

doi:10.1136/bmj.f4746

Perceived job insecurity as a risk factor for incident coronary heart disease: systematic review and meta-analysis

Marianna Virtanen, Solja T Nyberg, George David Batty, Markus Jokela, Katriina Heikkilä, Eleonor I Fransson, Lars Alfredsson, Jakob B Bjorner, Marianne Borritz, Hermann Burr, Annalisa Casini, Els Clays, Dirk De Bacquer, Nico Dragano, Marko Elovainio, Raimund Erbel, Jane E Ferrie, Mark Hamer, Karl-Heinz Jöckel, France KittelAnders Knutsson, Markku Koskenvuo, Aki Koskinen, Thorsten Lunau, Ida Elisabeth Huitfeldt Madsen, Martin L Nielsen, Maria Nordin, Tuula Oksanen, Krista Pahkin, Jan Pejtersen, Jaana Pentti, Reiner Ernst Rugulies, Paula Salo, Martin J Shipley, Johannes Siegrist, Andrew Steptoe, Sakari B Suominen, Töres Theorell, Salla Toppinen-Tanner, Ari Väänänen, Jussi Vahtera, Peter J M Westerholm, Hugo Westerlund, Natalie Slopen, Ichiro Kawachi, Archana Singh-Manoux, Mika Kivimäki, IPD-Work Consortium

Section of Social Medicine

127 Citations (Scopus)

Abstract

Objective To determine the association between self reported job insecurity and incident coronary heart disease. Design A meta-analysis combining individual level data from a collaborative consortium and published studies identified by a systematic review. Data sources We obtained individual level data from 13 cohort studies participating in the Individual-Participant-Data Meta-analysis in Working Populations Consortium. Four published prospective cohort studies were identified by searches of Medline (to August 2012) and Embase databases (to October 2012), supplemented by manual searches. Review methods Prospective cohort studies that reported risk estimates for clinically verified incident coronary heart disease by the level of self reported job insecurity. Two independent reviewers extracted published data. Summary estimates of association were obtained using random effects models. Results The literature search yielded four cohort studies. Together with 13 cohort studies with individual participant data, the meta-analysis comprised up to 174 438 participants with a mean follow-up of 9.7 years and 1892 incident cases of coronary heart disease. Age adjusted relative risk of high versus low job insecurity was 1.32 (95% confidence interval 1.09 to 1.59). The relative risk of job insecurity adjusted for sociodemographic and risk factors was 1.19 (1.00 to 1.42). There was no evidence of significant differences in this association by sex, age (<50 v =50 years), national unemployment rate, welfare regime, or job insecurity measure. Conclusions The modest association between perceived job insecurity and incident coronary heart disease is partly attributable to poorer socioeconomic circumstances and less favourable risk factor profiles among people with job insecurity.

Original language	English
Article number	f4746
Journal	B M J (Online)
Volume	347
Pages (from-to)	1-16
Number of pages	16
ISSN	1756-1833
DOIs	https://doi.org/10.1136/bmj.f4746
Publication status	Published - 17 Aug 2013

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Virtanen, M., Nyberg, S. T., Batty, G. D., Jokela, M., Heikkilä, K., Fransson, E. I., Alfredsson, L., Bjorner, J. B., Borritz, M., Burr, H., Casini, A., Clays, E., De Bacquer, D., Dragano, N., Elovainio, M., Erbel, R., Ferrie, J. E., Hamer, M., Jöckel, K-H., ... Consortium, IPD-W. (2013). Perceived job insecurity as a risk factor for incident coronary heart disease: systematic review and meta-analysis. B M J (Online), 347, 1-16. [f4746]. https://doi.org/10.1136/bmj.f4746

Virtanen, M, Nyberg, ST, Batty, GD, Jokela, M, Heikkilä, K, Fransson, EI, Alfredsson, L, Bjorner, JB, Borritz, M, Burr, H, Casini, A, Clays, E, De Bacquer, D, Dragano, N, Elovainio, M, Erbel, R, Ferrie, JE, Hamer, M, Jöckel, K-H, Kittel, F, Knutsson, A, Koskenvuo, M, Koskinen, A, Lunau, T, Madsen, IEH, Nielsen, ML, Nordin, M, Oksanen, T, Pahkin, K, Pejtersen, J, Pentti, J, Rugulies, RE, Salo, P, Shipley, MJ, Siegrist, J, Steptoe, A, Suominen, SB, Theorell, T, Toppinen-Tanner, S, Väänänen, A, Vahtera, J, Westerholm, PJM, Westerlund, H, Slopen, N, Kawachi, I, Singh-Manoux, A, Kivimäki, M & Consortium, IPD-W 2013, 'Perceived job insecurity as a risk factor for incident coronary heart disease: systematic review and meta-analysis', B M J (Online), vol. 347, f4746, pp. 1-16. https://doi.org/10.1136/bmj.f4746

@article{d136438b65cb44419fb45c148041f545,

title = "Perceived job insecurity as a risk factor for incident coronary heart disease: systematic review and meta-analysis",

abstract = "Objective To determine the association between self reported job insecurity and incident coronary heart disease. Design A meta-analysis combining individual level data from a collaborative consortium and published studies identified by a systematic review. Data sources We obtained individual level data from 13 cohort studies participating in the Individual-Participant-Data Meta-analysis in Working Populations Consortium. Four published prospective cohort studies were identified by searches of Medline (to August 2012) and Embase databases (to October 2012), supplemented by manual searches. Review methods Prospective cohort studies that reported risk estimates for clinically verified incident coronary heart disease by the level of self reported job insecurity. Two independent reviewers extracted published data. Summary estimates of association were obtained using random effects models. Results The literature search yielded four cohort studies. Together with 13 cohort studies with individual participant data, the meta-analysis comprised up to 174 438 participants with a mean follow-up of 9.7 years and 1892 incident cases of coronary heart disease. Age adjusted relative risk of high versus low job insecurity was 1.32 (95% confidence interval 1.09 to 1.59). The relative risk of job insecurity adjusted for sociodemographic and risk factors was 1.19 (1.00 to 1.42). There was no evidence of significant differences in this association by sex, age (<50 v =50 years), national unemployment rate, welfare regime, or job insecurity measure. Conclusions The modest association between perceived job insecurity and incident coronary heart disease is partly attributable to poorer socioeconomic circumstances and less favourable risk factor profiles among people with job insecurity.",

author = "Marianna Virtanen and Nyberg, {Solja T} and Batty, {George David} and Markus Jokela and Katriina Heikkil{\"a} and Fransson, {Eleonor I} and Lars Alfredsson and Bjorner, {Jakob B} and Marianne Borritz and Hermann Burr and Annalisa Casini and Els Clays and {De Bacquer}, Dirk and Nico Dragano and Marko Elovainio and Raimund Erbel and Ferrie, {Jane E} and Mark Hamer and Karl-Heinz J{\"o}ckel and France Kittel and Anders Knutsson and Markku Koskenvuo and Aki Koskinen and Thorsten Lunau and Madsen, {Ida Elisabeth Huitfeldt} and Nielsen, {Martin L} and Maria Nordin and Tuula Oksanen and Krista Pahkin and Jan Pejtersen and Jaana Pentti and Rugulies, {Reiner Ernst} and Paula Salo and Shipley, {Martin J} and Johannes Siegrist and Andrew Steptoe and Suominen, {Sakari B} and T{\"o}res Theorell and Salla Toppinen-Tanner and Ari V{\"a}{\"a}n{\"a}nen and Jussi Vahtera and Westerholm, {Peter J M} and Hugo Westerlund and Natalie Slopen and Ichiro Kawachi and Archana Singh-Manoux and Mika Kivim{\"a}ki and IPD-Work Consortium",

year = "2013",

month = aug,

day = "17",

doi = "10.1136/bmj.f4746",

language = "English",

volume = "347",

pages = "1--16",

journal = "BMJ",

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T1 - Perceived job insecurity as a risk factor for incident coronary heart disease

T2 - systematic review and meta-analysis

AU - Virtanen, Marianna

AU - Nyberg, Solja T

AU - Batty, George David

AU - Jokela, Markus

AU - Heikkilä, Katriina

AU - Fransson, Eleonor I

AU - Alfredsson, Lars

AU - Bjorner, Jakob B

AU - Borritz, Marianne

AU - Burr, Hermann

AU - Casini, Annalisa

AU - Clays, Els

AU - De Bacquer, Dirk

AU - Dragano, Nico

AU - Elovainio, Marko

AU - Erbel, Raimund

AU - Ferrie, Jane E

AU - Hamer, Mark

AU - Jöckel, Karl-Heinz

AU - Kittel, France

AU - Knutsson, Anders

AU - Koskenvuo, Markku

AU - Koskinen, Aki

AU - Lunau, Thorsten

AU - Madsen, Ida Elisabeth Huitfeldt

AU - Nielsen, Martin L

AU - Nordin, Maria

AU - Oksanen, Tuula

AU - Pahkin, Krista

AU - Pejtersen, Jan

AU - Pentti, Jaana

AU - Rugulies, Reiner Ernst

AU - Salo, Paula

AU - Shipley, Martin J

AU - Siegrist, Johannes

AU - Steptoe, Andrew

AU - Suominen, Sakari B

AU - Theorell, Töres

AU - Toppinen-Tanner, Salla

AU - Väänänen, Ari

AU - Vahtera, Jussi

AU - Westerholm, Peter J M

AU - Westerlund, Hugo

AU - Slopen, Natalie

AU - Kawachi, Ichiro

AU - Singh-Manoux, Archana

AU - Kivimäki, Mika

AU - Consortium, IPD-Work

PY - 2013/8/17

Y1 - 2013/8/17

N2 - Objective To determine the association between self reported job insecurity and incident coronary heart disease. Design A meta-analysis combining individual level data from a collaborative consortium and published studies identified by a systematic review. Data sources We obtained individual level data from 13 cohort studies participating in the Individual-Participant-Data Meta-analysis in Working Populations Consortium. Four published prospective cohort studies were identified by searches of Medline (to August 2012) and Embase databases (to October 2012), supplemented by manual searches. Review methods Prospective cohort studies that reported risk estimates for clinically verified incident coronary heart disease by the level of self reported job insecurity. Two independent reviewers extracted published data. Summary estimates of association were obtained using random effects models. Results The literature search yielded four cohort studies. Together with 13 cohort studies with individual participant data, the meta-analysis comprised up to 174 438 participants with a mean follow-up of 9.7 years and 1892 incident cases of coronary heart disease. Age adjusted relative risk of high versus low job insecurity was 1.32 (95% confidence interval 1.09 to 1.59). The relative risk of job insecurity adjusted for sociodemographic and risk factors was 1.19 (1.00 to 1.42). There was no evidence of significant differences in this association by sex, age (<50 v =50 years), national unemployment rate, welfare regime, or job insecurity measure. Conclusions The modest association between perceived job insecurity and incident coronary heart disease is partly attributable to poorer socioeconomic circumstances and less favourable risk factor profiles among people with job insecurity.

AB - Objective To determine the association between self reported job insecurity and incident coronary heart disease. Design A meta-analysis combining individual level data from a collaborative consortium and published studies identified by a systematic review. Data sources We obtained individual level data from 13 cohort studies participating in the Individual-Participant-Data Meta-analysis in Working Populations Consortium. Four published prospective cohort studies were identified by searches of Medline (to August 2012) and Embase databases (to October 2012), supplemented by manual searches. Review methods Prospective cohort studies that reported risk estimates for clinically verified incident coronary heart disease by the level of self reported job insecurity. Two independent reviewers extracted published data. Summary estimates of association were obtained using random effects models. Results The literature search yielded four cohort studies. Together with 13 cohort studies with individual participant data, the meta-analysis comprised up to 174 438 participants with a mean follow-up of 9.7 years and 1892 incident cases of coronary heart disease. Age adjusted relative risk of high versus low job insecurity was 1.32 (95% confidence interval 1.09 to 1.59). The relative risk of job insecurity adjusted for sociodemographic and risk factors was 1.19 (1.00 to 1.42). There was no evidence of significant differences in this association by sex, age (<50 v =50 years), national unemployment rate, welfare regime, or job insecurity measure. Conclusions The modest association between perceived job insecurity and incident coronary heart disease is partly attributable to poorer socioeconomic circumstances and less favourable risk factor profiles among people with job insecurity.

U2 - 10.1136/bmj.f4746

DO - 10.1136/bmj.f4746

M3 - Journal article

SN - 0959-8146

VL - 347

SP - 1

EP - 16

JO - BMJ

JF - BMJ

M1 - f4746

ER -

Perceived job insecurity as a risk factor for incident coronary heart disease: systematic review and meta-analysis

Abstract

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