Pancreatic beta cell function increases in a linear dose-response manner following exercise training in adults with prediabetes

Steven K Malin; Thomas Solomon; Alecia Blaszczak; Stephen Finnegan; Julianne Filion; John P Kirwan

doi:10.1152/ajpendo.00260.2013

Pancreatic beta cell function increases in a linear dose-response manner following exercise training in adults with prediabetes

Steven K Malin, Thomas Solomon, Alecia Blaszczak, Stephen Finnegan, Julianne Filion, John P Kirwan

Inflammation, Metabolism and Oxidation

59 Citations (Scopus)

Abstract

Although some studies suggest that a linear dose-response relationship exists between exercise and insulin sensitivity, the exercise dose required to enhance pancreatic (3-cell function is unknown. Thirty-five older obese adults with prediabetes underwent a progressive 12-wk supervised exercise intervention (5 days/wk for 60 min at ~85% HR_max). Insulin and C-peptide responses to an OGTT were used to define the first- and second-phase disposition index (DI; (3-cell function = glucose-stimulated insulin secretion ̇ clamp-derived insulin sensitivity). Maximum oxygen consumption (V_O2max) and body composition (dual-energy X-ray absorptiometry and computed tomography) were also measured before and after the intervention. Exercise dose was computed using V_O2/heart-rate derived linear regression equations. Subjects expended 474.5 ± 8.8 kcal/session (2,372.5 ± 44.1 kcal/wk) during the intervention and lost ~8% body weight. Exercise increased first- and second-phase DI (P < 0.05), and these changes in DI were linearly related to exercise dose (DI_first phase: r = 0.54, P < 0.001; DI_second phase: r = 0.56, P = 0.0005). Enhanced DI was also associated with increased VO_2max (DIfi_rst phase: r = 0.36, P = 0.04; DIsecond phase: r = 0.41, P < 0.02) but not lower body fat (DI_firs_t phase: r = -0.21, P = 0.25; DI_{second ph}ase: r = -0.30, P = 0.10) after training. Low baseline DI predicted an increase in DI after the intervention (DI_{first phase}: r = -0.37; DI_{second ph}ase: r = -0.41, each P < 0.04). Thus, exercise training plus weight loss increased pancreatic (3-cell function in a linear dose-response manner in adults with prediabetes. Our data suggest that higher exercise doses (i.e., >2,000 kcal/wk) are necessary to enhance (3-cell function in adults with poor insulin secretion capacity.

Original language	English
Journal	A J P: Endocrinology and Metabolism (Online)
Volume	395
Issue number	5
Pages (from-to)	E1248-54
Number of pages	7
ISSN	1522-1555
DOIs	https://doi.org/10.1152/ajpendo.00260.2013
Publication status	Published - 15 Nov 2013

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Pancreatic beta cell function increases in a linear dose-response manner following exercise training in adults with prediabetes. / Malin, Steven K; Solomon, Thomas; Blaszczak, Alecia et al.

In: A J P: Endocrinology and Metabolism (Online), Vol. 395, No. 5, 15.11.2013, p. E1248-54.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Pancreatic beta cell function increases in a linear dose-response manner following exercise training in adults with prediabetes",

abstract = "Although some studies suggest that a linear dose-response relationship exists between exercise and insulin sensitivity, the exercise dose required to enhance pancreatic (3-cell function is unknown. Thirty-five older obese adults with prediabetes underwent a progressive 12-wk supervised exercise intervention (5 days/wk for 60 min at ~85% HRmax). Insulin and C-peptide responses to an OGTT were used to define the first- and second-phase disposition index (DI; (3-cell function = glucose-stimulated insulin secretion{\. } clamp-derived insulin sensitivity). Maximum oxygen consumption (VO2max) and body composition (dual-energy X-ray absorptiometry and computed tomography) were also measured before and after the intervention. Exercise dose was computed using VO2/heart-rate derived linear regression equations. Subjects expended 474.5 ± 8.8 kcal/session (2,372.5 ± 44.1 kcal/wk) during the intervention and lost ~8% body weight. Exercise increased first- and second-phase DI (P < 0.05), and these changes in DI were linearly related to exercise dose (DIfirst phase: r = 0.54, P < 0.001; DIsecond phase: r = 0.56, P = 0.0005). Enhanced DI was also associated with increased VO2max (DIfirst phase: r = 0.36, P = 0.04; DIsecond phase: r = 0.41, P < 0.02) but not lower body fat (DIfirst phase: r = -0.21, P = 0.25; DIsecond phase: r = -0.30, P = 0.10) after training. Low baseline DI predicted an increase in DI after the intervention (DIfirst phase: r = -0.37; DIsecond phase: r = -0.41, each P < 0.04). Thus, exercise training plus weight loss increased pancreatic (3-cell function in a linear dose-response manner in adults with prediabetes. Our data suggest that higher exercise doses (i.e., >2,000 kcal/wk) are necessary to enhance (3-cell function in adults with poor insulin secretion capacity.",

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T1 - Pancreatic beta cell function increases in a linear dose-response manner following exercise training in adults with prediabetes

AU - Malin, Steven K

AU - Solomon, Thomas

AU - Blaszczak, Alecia

AU - Finnegan, Stephen

AU - Filion, Julianne

AU - Kirwan, John P

PY - 2013/11/15

Y1 - 2013/11/15

N2 - Although some studies suggest that a linear dose-response relationship exists between exercise and insulin sensitivity, the exercise dose required to enhance pancreatic (3-cell function is unknown. Thirty-five older obese adults with prediabetes underwent a progressive 12-wk supervised exercise intervention (5 days/wk for 60 min at ~85% HRmax). Insulin and C-peptide responses to an OGTT were used to define the first- and second-phase disposition index (DI; (3-cell function = glucose-stimulated insulin secretion ̇ clamp-derived insulin sensitivity). Maximum oxygen consumption (VO2max) and body composition (dual-energy X-ray absorptiometry and computed tomography) were also measured before and after the intervention. Exercise dose was computed using VO2/heart-rate derived linear regression equations. Subjects expended 474.5 ± 8.8 kcal/session (2,372.5 ± 44.1 kcal/wk) during the intervention and lost ~8% body weight. Exercise increased first- and second-phase DI (P < 0.05), and these changes in DI were linearly related to exercise dose (DIfirst phase: r = 0.54, P < 0.001; DIsecond phase: r = 0.56, P = 0.0005). Enhanced DI was also associated with increased VO2max (DIfirst phase: r = 0.36, P = 0.04; DIsecond phase: r = 0.41, P < 0.02) but not lower body fat (DIfirst phase: r = -0.21, P = 0.25; DIsecond phase: r = -0.30, P = 0.10) after training. Low baseline DI predicted an increase in DI after the intervention (DIfirst phase: r = -0.37; DIsecond phase: r = -0.41, each P < 0.04). Thus, exercise training plus weight loss increased pancreatic (3-cell function in a linear dose-response manner in adults with prediabetes. Our data suggest that higher exercise doses (i.e., >2,000 kcal/wk) are necessary to enhance (3-cell function in adults with poor insulin secretion capacity.

AB - Although some studies suggest that a linear dose-response relationship exists between exercise and insulin sensitivity, the exercise dose required to enhance pancreatic (3-cell function is unknown. Thirty-five older obese adults with prediabetes underwent a progressive 12-wk supervised exercise intervention (5 days/wk for 60 min at ~85% HRmax). Insulin and C-peptide responses to an OGTT were used to define the first- and second-phase disposition index (DI; (3-cell function = glucose-stimulated insulin secretion ̇ clamp-derived insulin sensitivity). Maximum oxygen consumption (VO2max) and body composition (dual-energy X-ray absorptiometry and computed tomography) were also measured before and after the intervention. Exercise dose was computed using VO2/heart-rate derived linear regression equations. Subjects expended 474.5 ± 8.8 kcal/session (2,372.5 ± 44.1 kcal/wk) during the intervention and lost ~8% body weight. Exercise increased first- and second-phase DI (P < 0.05), and these changes in DI were linearly related to exercise dose (DIfirst phase: r = 0.54, P < 0.001; DIsecond phase: r = 0.56, P = 0.0005). Enhanced DI was also associated with increased VO2max (DIfirst phase: r = 0.36, P = 0.04; DIsecond phase: r = 0.41, P < 0.02) but not lower body fat (DIfirst phase: r = -0.21, P = 0.25; DIsecond phase: r = -0.30, P = 0.10) after training. Low baseline DI predicted an increase in DI after the intervention (DIfirst phase: r = -0.37; DIsecond phase: r = -0.41, each P < 0.04). Thus, exercise training plus weight loss increased pancreatic (3-cell function in a linear dose-response manner in adults with prediabetes. Our data suggest that higher exercise doses (i.e., >2,000 kcal/wk) are necessary to enhance (3-cell function in adults with poor insulin secretion capacity.

U2 - 10.1152/ajpendo.00260.2013

DO - 10.1152/ajpendo.00260.2013

M3 - Journal article

C2 - 24045867

SN - 1522-1555

VL - 395

SP - E1248-54

JO - A J P: Endocrinology and Metabolism (Online)

JF - A J P: Endocrinology and Metabolism (Online)

IS - 5

ER -

Pancreatic beta cell function increases in a linear dose-response manner following exercise training in adults with prediabetes

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