Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans: The NUGENOB Study

Eva Corpeleijn; Liselotte Petersen; Claus Holst; Wim H. Saris; Arne Astrup; Dominique Langin; Ian Macdonald; J. Alfredo Martinez; Jean-Michel Oppert; Jan Polak; Oluf Borbye Pedersen; Philippe Froguel; Peter Arner; Thorkild I.A. Sørensen; Ellen E. Blaak

doi:10.1038/oby.2009.377

Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans: The NUGENOB Study

Eva Corpeleijn, Liselotte Petersen, Claus Holst, Wim H. Saris, Arne Astrup, Dominique Langin, Ian Macdonald, J. Alfredo Martinez, Jean-Michel Oppert, Jan Polak, Oluf Borbye Pedersen, Philippe Froguel, Peter Arner, Thorkild I.A. Sørensen, Ellen E. Blaak

37 Citations (Scopus)

Abstract

Both obesity and insulin resistance have been related to low fat oxidation rates, which may be genetically determined. The association between variation in fat oxidation rates among obese subjects and genotype was studied for 42 common single-nucleotide polymorphisms (SNPs) in 26 candidate genes for fat oxidation, insulin resistance, and obesity, including FTO. Energy expenditure (EE) and fat oxidation were measured with indirect calorimetry during fasting and 3 h after a high fat load containing 95 energy% of fat (60% saturated fat, energy content 50% of estimated resting EE) in 722 obese subjects (541 women, 181 men) from 8 European centers. After adjustment for center and gender, -178 A>C CD36 (rs2232169) (P = 0.02), -22510 C>G SLC6A14 (women, rs2011162) (P = 0.03), and T690S C>G PCSK1 (rs6235) (P = 0.02) were related to a reduced fat oxidation, whereas 17 C>G SREBF1 (17 C>G) (P = 0.01) was related to increased fat oxidation in the fasting state. The ability to increase fat oxidation after a high fat load was increased in subjects with -174 G>C IL6 (rs1800795) (P = 0.01). Effect sizes range from 1.1 to 3.1% differences in fat oxidation (expressed as % of EE). FTO rs9939609 was not related to fat oxidation. At the same time, the results are not adjusted for multiple testing, thus none of the associations can be considered statistically significant. The results should therefore only be considered as leads to new hypotheses about effects of specific genetic polymorphisms on fasting and postprandial fat oxidation.

Original language	English
Journal	Obesity
Volume	18
Issue number	7
Pages (from-to)	1369-1377
Number of pages	9
ISSN	1930-7381
DOIs	https://doi.org/10.1038/oby.2009.377
Publication status	Published - Jul 2010

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Corpeleijn, E., Petersen, L., Holst, C., Saris, W. H., Astrup, A., Langin, D., Macdonald, I., Martinez, J. A., Oppert, J-M., Polak, J., Pedersen, O. B., Froguel, P., Arner, P., Sørensen, T. I. A., & Blaak, E. E. (2010). Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans: The NUGENOB Study. Obesity, 18(7), 1369-1377. https://doi.org/10.1038/oby.2009.377

Corpeleijn, E, Petersen, L, Holst, C, Saris, WH, Astrup, A, Langin, D, Macdonald, I, Martinez, JA, Oppert, J-M, Polak, J, Pedersen, OB, Froguel, P, Arner, P, Sørensen, TIA & Blaak, EE 2010, 'Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans: The NUGENOB Study', Obesity, vol. 18, no. 7, pp. 1369-1377. https://doi.org/10.1038/oby.2009.377

@article{ea123e5035ae11df8ed1000ea68e967b,

title = "Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans: The NUGENOB Study",

abstract = "Both obesity and insulin resistance have been related to low fat oxidation rates, which may be genetically determined. The association between variation in fat oxidation rates among obese subjects and genotype was studied for 42 common single-nucleotide polymorphisms (SNPs) in 26 candidate genes for fat oxidation, insulin resistance, and obesity, including FTO. Energy expenditure (EE) and fat oxidation were measured with indirect calorimetry during fasting and 3 h after a high fat load containing 95 energy% of fat (60% saturated fat, energy content 50% of estimated resting EE) in 722 obese subjects (541 women, 181 men) from 8 European centers. After adjustment for center and gender, -178 A>C CD36 (rs2232169) (P = 0.02), -22510 C>G SLC6A14 (women, rs2011162) (P = 0.03), and T690S C>G PCSK1 (rs6235) (P = 0.02) were related to a reduced fat oxidation, whereas 17 C>G SREBF1 (17 C>G) (P = 0.01) was related to increased fat oxidation in the fasting state. The ability to increase fat oxidation after a high fat load was increased in subjects with -174 G>C IL6 (rs1800795) (P = 0.01). Effect sizes range from 1.1 to 3.1% differences in fat oxidation (expressed as % of EE). FTO rs9939609 was not related to fat oxidation. At the same time, the results are not adjusted for multiple testing, thus none of the associations can be considered statistically significant. The results should therefore only be considered as leads to new hypotheses about effects of specific genetic polymorphisms on fasting and postprandial fat oxidation.",

author = "Eva Corpeleijn and Liselotte Petersen and Claus Holst and Saris, {Wim H.} and Arne Astrup and Dominique Langin and Ian Macdonald and Martinez, {J. Alfredo} and Jean-Michel Oppert and Jan Polak and Pedersen, {Oluf Borbye} and Philippe Froguel and Peter Arner and S{\o}rensen, {Thorkild I.A.} and Blaak, {Ellen E.}",

year = "2010",

month = jul,

doi = "10.1038/oby.2009.377",

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volume = "18",

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T1 - Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans

T2 - The NUGENOB Study

AU - Corpeleijn, Eva

AU - Petersen, Liselotte

AU - Holst, Claus

AU - Saris, Wim H.

AU - Astrup, Arne

AU - Langin, Dominique

AU - Macdonald, Ian

AU - Martinez, J. Alfredo

AU - Oppert, Jean-Michel

AU - Polak, Jan

AU - Pedersen, Oluf Borbye

AU - Froguel, Philippe

AU - Arner, Peter

AU - Sørensen, Thorkild I.A.

AU - Blaak, Ellen E.

PY - 2010/7

Y1 - 2010/7

N2 - Both obesity and insulin resistance have been related to low fat oxidation rates, which may be genetically determined. The association between variation in fat oxidation rates among obese subjects and genotype was studied for 42 common single-nucleotide polymorphisms (SNPs) in 26 candidate genes for fat oxidation, insulin resistance, and obesity, including FTO. Energy expenditure (EE) and fat oxidation were measured with indirect calorimetry during fasting and 3 h after a high fat load containing 95 energy% of fat (60% saturated fat, energy content 50% of estimated resting EE) in 722 obese subjects (541 women, 181 men) from 8 European centers. After adjustment for center and gender, -178 A>C CD36 (rs2232169) (P = 0.02), -22510 C>G SLC6A14 (women, rs2011162) (P = 0.03), and T690S C>G PCSK1 (rs6235) (P = 0.02) were related to a reduced fat oxidation, whereas 17 C>G SREBF1 (17 C>G) (P = 0.01) was related to increased fat oxidation in the fasting state. The ability to increase fat oxidation after a high fat load was increased in subjects with -174 G>C IL6 (rs1800795) (P = 0.01). Effect sizes range from 1.1 to 3.1% differences in fat oxidation (expressed as % of EE). FTO rs9939609 was not related to fat oxidation. At the same time, the results are not adjusted for multiple testing, thus none of the associations can be considered statistically significant. The results should therefore only be considered as leads to new hypotheses about effects of specific genetic polymorphisms on fasting and postprandial fat oxidation.

AB - Both obesity and insulin resistance have been related to low fat oxidation rates, which may be genetically determined. The association between variation in fat oxidation rates among obese subjects and genotype was studied for 42 common single-nucleotide polymorphisms (SNPs) in 26 candidate genes for fat oxidation, insulin resistance, and obesity, including FTO. Energy expenditure (EE) and fat oxidation were measured with indirect calorimetry during fasting and 3 h after a high fat load containing 95 energy% of fat (60% saturated fat, energy content 50% of estimated resting EE) in 722 obese subjects (541 women, 181 men) from 8 European centers. After adjustment for center and gender, -178 A>C CD36 (rs2232169) (P = 0.02), -22510 C>G SLC6A14 (women, rs2011162) (P = 0.03), and T690S C>G PCSK1 (rs6235) (P = 0.02) were related to a reduced fat oxidation, whereas 17 C>G SREBF1 (17 C>G) (P = 0.01) was related to increased fat oxidation in the fasting state. The ability to increase fat oxidation after a high fat load was increased in subjects with -174 G>C IL6 (rs1800795) (P = 0.01). Effect sizes range from 1.1 to 3.1% differences in fat oxidation (expressed as % of EE). FTO rs9939609 was not related to fat oxidation. At the same time, the results are not adjusted for multiple testing, thus none of the associations can be considered statistically significant. The results should therefore only be considered as leads to new hypotheses about effects of specific genetic polymorphisms on fasting and postprandial fat oxidation.

U2 - 10.1038/oby.2009.377

DO - 10.1038/oby.2009.377

M3 - Journal article

C2 - 19876004

SN - 1930-7381

VL - 18

SP - 1369

EP - 1377

JO - Obesity

JF - Obesity

IS - 7

ER -

Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans: The NUGENOB Study

Abstract

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