Abstract
Context. Low birth weight (LBW) is associated with increased risk of Type 2 diabetes mellitus. An impaired incretin effect was previously reported in type 2 diabetic patients. Objective. We studied the secretion and action of GLP-1 and GIP in young LBW men (n = 24) and matched normal birth weight controls (NBW) (n = 25). Results. LBW subjects were 5 cm shorter, but had BMI similar to NBW. LBW subjects had significantly elevated fasting and postprandial p-glucose, as well as postprandial (standard meal test) p-insulin and C-peptide concentrations, suggestive of insulin resistance. Insulin secretion in response to changes in glucose concentration ("beta-cell-responsiveness") during the meal test was similar in LBW and NBW, but inappropriate in LBW relative to insulin sensitivity. Fasting and postprandial p-GLP-1 and GIP was similar in the groups. First and second phase insulin responses were similar in LBW and NBW during a hyperglycemic clamp (7 mM) with infusion of GLP-1 or GIP, respectively, demonstrating normal action of these hormones on insulin secretion. Conclusion. Reduced secretion or action of GLP-1 or GIP does not explain a relative reduced beta-cell responsiveness to glucose or the slightly elevated p-glucose concentrations observed in young LBW men.
| Translated title of the contribution | Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in young men with low birth weight. |
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| Original language | English |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Pages (from-to) | 0-0 |
| ISSN | 0021-972X |
| Publication status | Published - 2005 |