No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial

B Kücükakin; M Wilhelmsen; Jens Lykkesfeldt; R J Reiter; J Rosenberg; I Gögenur

doi:http://dx.doi.org/10.1016/j.ejvs.2010.06.014

No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial

B Kücükakin, M Wilhelmsen, Jens Lykkesfeldt, R J Reiter, J Rosenberg, I Gögenur

24 Citations (Scopus)

Abstract

Background: A possible mechanism underlying cardiovascular morbidity after major vascular surgery may be the perioperative ischaemiaereperfusion with excessive oxygen-derived free-radical production and increased levels of circulating inflammatory mediators. We examined the effect of melatonin infusion during surgery and oral melatonin treatment for 3 days after surgery on biochemical markers of oxidative and inflammatory stress. Methods: Patients received an intra-operative intravenous infusion of 50 mg melatonin or placebo. In addition, all patients received 10 mg melatonin or placebo orally the first 3 nights after surgery. Blood samples for analysis of malondialdehyde (MDA), ascorbic acid (AA), dehydroascorbic acid (DHA) and C-reactive protein (CRP) were collected preoperatively, and at 5 min, 6 h and 24 h after clamp removal (recirculation of the first leg). Results: Twenty-six patients received melatonin and 24 patients received placebo. No significant differences were observed in any of the oxidative and inflammatory stress parameters. There were significantly more side effects in the melatonin group than in the placebo group. Conclusions: Melatonin treatment in the perioperative period did not reduce the oxidative and inflammatory parameters measured in this study.

Original language	English
Journal	European Journal of Vascular and Endovascular Surgery
Volume	40
Issue number	4
Pages (from-to)	461-7
Number of pages	7
ISSN	1078-5884
DOIs	https://doi.org/10.1016/j.ejvs.2010.06.014
Publication status	Published - 1 Oct 2010

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No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial. / Kücükakin, B; Wilhelmsen, M; Lykkesfeldt, Jens et al.

In: European Journal of Vascular and Endovascular Surgery, Vol. 40, No. 4, 01.10.2010, p. 461-7.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial",

abstract = "Background: A possible mechanism underlying cardiovascular morbidity after major vascular surgery may be the perioperative ischaemiaereperfusion with excessive oxygen-derived free-radical production and increased levels of circulating inflammatory mediators. We examined the effect of melatonin infusion during surgery and oral melatonin treatment for 3 days after surgery on biochemical markers of oxidative and inflammatory stress. Methods: Patients received an intra-operative intravenous infusion of 50 mg melatonin or placebo. In addition, all patients received 10 mg melatonin or placebo orally the first 3 nights after surgery. Blood samples for analysis of malondialdehyde (MDA), ascorbic acid (AA), dehydroascorbic acid (DHA) and C-reactive protein (CRP) were collected preoperatively, and at 5 min, 6 h and 24 h after clamp removal (recirculation of the first leg). Results: Twenty-six patients received melatonin and 24 patients received placebo. No significant differences were observed in any of the oxidative and inflammatory stress parameters. There were significantly more side effects in the melatonin group than in the placebo group. Conclusions: Melatonin treatment in the perioperative period did not reduce the oxidative and inflammatory parameters measured in this study.",

author = "B K{\"u}c{\"u}kakin and M Wilhelmsen and Jens Lykkesfeldt and Reiter, {R J} and J Rosenberg and I G{\"o}genur",

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T1 - No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial

AU - Kücükakin, B

AU - Wilhelmsen, M

AU - Lykkesfeldt, Jens

AU - Reiter, R J

AU - Rosenberg, J

AU - Gögenur, I

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Background: A possible mechanism underlying cardiovascular morbidity after major vascular surgery may be the perioperative ischaemiaereperfusion with excessive oxygen-derived free-radical production and increased levels of circulating inflammatory mediators. We examined the effect of melatonin infusion during surgery and oral melatonin treatment for 3 days after surgery on biochemical markers of oxidative and inflammatory stress. Methods: Patients received an intra-operative intravenous infusion of 50 mg melatonin or placebo. In addition, all patients received 10 mg melatonin or placebo orally the first 3 nights after surgery. Blood samples for analysis of malondialdehyde (MDA), ascorbic acid (AA), dehydroascorbic acid (DHA) and C-reactive protein (CRP) were collected preoperatively, and at 5 min, 6 h and 24 h after clamp removal (recirculation of the first leg). Results: Twenty-six patients received melatonin and 24 patients received placebo. No significant differences were observed in any of the oxidative and inflammatory stress parameters. There were significantly more side effects in the melatonin group than in the placebo group. Conclusions: Melatonin treatment in the perioperative period did not reduce the oxidative and inflammatory parameters measured in this study.

AB - Background: A possible mechanism underlying cardiovascular morbidity after major vascular surgery may be the perioperative ischaemiaereperfusion with excessive oxygen-derived free-radical production and increased levels of circulating inflammatory mediators. We examined the effect of melatonin infusion during surgery and oral melatonin treatment for 3 days after surgery on biochemical markers of oxidative and inflammatory stress. Methods: Patients received an intra-operative intravenous infusion of 50 mg melatonin or placebo. In addition, all patients received 10 mg melatonin or placebo orally the first 3 nights after surgery. Blood samples for analysis of malondialdehyde (MDA), ascorbic acid (AA), dehydroascorbic acid (DHA) and C-reactive protein (CRP) were collected preoperatively, and at 5 min, 6 h and 24 h after clamp removal (recirculation of the first leg). Results: Twenty-six patients received melatonin and 24 patients received placebo. No significant differences were observed in any of the oxidative and inflammatory stress parameters. There were significantly more side effects in the melatonin group than in the placebo group. Conclusions: Melatonin treatment in the perioperative period did not reduce the oxidative and inflammatory parameters measured in this study.

U2 - http://dx.doi.org/10.1016/j.ejvs.2010.06.014

DO - http://dx.doi.org/10.1016/j.ejvs.2010.06.014

M3 - Journal article

SN - 1078-5884

VL - 40

SP - 461

EP - 467

JO - European Journal of Vascular and Endovascular Surgery

JF - European Journal of Vascular and Endovascular Surgery

IS - 4

ER -

No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial

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