Mice lacking neuropeptide Y show increased sensitivity to cocaine

Gunnar Sørensen; David Paul Drucker Woldbye

doi:10.1002/syn.21568

Mice lacking neuropeptide Y show increased sensitivity to cocaine

Gunnar Sørensen, David Paul Drucker Woldbye

12 Citations (Scopus)

Abstract

There is increasing data implicating neuropeptide Y (NPY) in the neurobiology of addiction. This study explored the possible role of NPY in cocaine-induced behavior using NPY knockout mice. The transgenic mice showed a hypersensitive response to cocaine in three animal models of cocaine addiction. Whether this is due to an observed compensatory increase in striatal dopamine transporter binding or an anxiogenic phenotype of the transgenic mice remains to be determined.

Original language	English
Journal	Synapse
Volume	66
Pages (from-to)	840-3
Number of pages	4
ISSN	0887-4476
DOIs	https://doi.org/10.1002/syn.21568
Publication status	Published - Sept 2012

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10.1002/syn.21568

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title = "Mice lacking neuropeptide Y show increased sensitivity to cocaine",

abstract = "There is increasing data implicating neuropeptide Y (NPY) in the neurobiology of addiction. This study explored the possible role of NPY in cocaine-induced behavior using NPY knockout mice. The transgenic mice showed a hypersensitive response to cocaine in three animal models of cocaine addiction. Whether this is due to an observed compensatory increase in striatal dopamine transporter binding or an anxiogenic phenotype of the transgenic mice remains to be determined.",

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AB - There is increasing data implicating neuropeptide Y (NPY) in the neurobiology of addiction. This study explored the possible role of NPY in cocaine-induced behavior using NPY knockout mice. The transgenic mice showed a hypersensitive response to cocaine in three animal models of cocaine addiction. Whether this is due to an observed compensatory increase in striatal dopamine transporter binding or an anxiogenic phenotype of the transgenic mice remains to be determined.

U2 - 10.1002/syn.21568

DO - 10.1002/syn.21568

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VL - 66

SP - 840

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JO - Synapse

JF - Synapse

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Mice lacking neuropeptide Y show increased sensitivity to cocaine

Abstract

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