Membrane protein-lipid match and mismatch

O. G. Mouritsen

doi:10.1016/b978-0-12-374920-8.00521-x

Membrane protein-lipid match and mismatch

O. G. Mouritsen^*

^*Corresponding author for this work

4 Citations (Scopus)

Abstract

Lipid-protein interactions are described with a focus on the physical interactions between lipids and integral proteins in lipid-bilayer membranes. The concepts of hydrophobic matching and curvature stress are presented and the effects of match vs mismatch is considered in light of data obtained from experimental and theoretical studies which demonstrate that not only do integral proteins perturb the lipids, but the physical state of the lipids does also actively influence protein function.

Original language	English
Title of host publication	Comprehensive Biophysics
Number of pages	16
Volume	5
Publisher	Elsevier Science Inc.
Publication date	1 Dec 2012
Pages	245-260
ISBN (Print)	9780080957180
DOIs	https://doi.org/10.1016/b978-0-12-374920-8.00521-x
Publication status	Published - 1 Dec 2012

Keywords

Hydrophobic matching
Hydrophobic thickness
Integral membrane protein
Lipid bilayer
Membrane organization
Structure-function relationship
Wetting

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10.1016/b978-0-12-374920-8.00521-x

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AB - Lipid-protein interactions are described with a focus on the physical interactions between lipids and integral proteins in lipid-bilayer membranes. The concepts of hydrophobic matching and curvature stress are presented and the effects of match vs mismatch is considered in light of data obtained from experimental and theoretical studies which demonstrate that not only do integral proteins perturb the lipids, but the physical state of the lipids does also actively influence protein function.

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KW - Hydrophobic thickness

KW - Integral membrane protein

KW - Lipid bilayer

KW - Membrane organization

KW - Structure-function relationship

KW - Wetting

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ER -

Membrane protein-lipid match and mismatch

Abstract

Keywords

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