TY - JOUR
T1 - Maternal folic acid supplement intake and semen quality in Danish sons
T2 - a follow-up study
AU - Jacobsen, Kristoffer
AU - Ramlau-Hansen, Cecilia Høst
AU - Thulstrup, Ane Marie
AU - Olsen, Jørn
AU - Bonde, Jens Peter
N1 - Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
PY - 2011/8
Y1 - 2011/8
N2 - Objective: To examine whether maternal folic acid supplement intake during pregnancy is related to better semen quality in male offspring. Design: A follow-up study. Setting: Two major Danish municipalities, Aalborg and Odense. Patient(s): The study population included 347 singleton sons of mothers enrolled into the Healthy Habits for Two cohort when pregnant in 1984-87. Intervention(s): Information on maternal folic acid supplement intake during pregnancy was provided by self-administered questionnaire in the 36th week of gestation. Main Outcome Measure(s): Semen characteristics and serum concentrations of sex hormones. Result(s): The distribution of semen characteristics among sons whose mothers took folic acid supplement during pregnancy (n = 88, 25%) did not differ from the distributions among those without (n = 75, 22%) or with unknown folic acid supplement intake (n = 84, 53%). On the contrary, serum levels of FSH and LH were significantly higher in the folic acid supplement group. Conclusion(s): The hypothesis that folic acid supplement intake during pregnancy will improve semen quality in male offspring was not corroborated by a follow-up study in young Danish men.
AB - Objective: To examine whether maternal folic acid supplement intake during pregnancy is related to better semen quality in male offspring. Design: A follow-up study. Setting: Two major Danish municipalities, Aalborg and Odense. Patient(s): The study population included 347 singleton sons of mothers enrolled into the Healthy Habits for Two cohort when pregnant in 1984-87. Intervention(s): Information on maternal folic acid supplement intake during pregnancy was provided by self-administered questionnaire in the 36th week of gestation. Main Outcome Measure(s): Semen characteristics and serum concentrations of sex hormones. Result(s): The distribution of semen characteristics among sons whose mothers took folic acid supplement during pregnancy (n = 88, 25%) did not differ from the distributions among those without (n = 75, 22%) or with unknown folic acid supplement intake (n = 84, 53%). On the contrary, serum levels of FSH and LH were significantly higher in the folic acid supplement group. Conclusion(s): The hypothesis that folic acid supplement intake during pregnancy will improve semen quality in male offspring was not corroborated by a follow-up study in young Danish men.
U2 - 10.1016/j.fertnstert.2011.05.037
DO - 10.1016/j.fertnstert.2011.05.037
M3 - Journal article
C2 - 21664612
SN - 1546-2501
VL - 96
SP - 295
EP - 298
JO - Sexuality, Reproduction and Menopause
JF - Sexuality, Reproduction and Menopause
IS - 2
ER -