Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts

Daniela Zugna; Claudia Galassi; Isabella Annesi-Maesano; Nour Baïz; Henrique Barros; Mikel Basterrechea; Sofia Correia; Liesbeth Duijts; Ana Esplugues; Maria Pia Fantini; Francesco Forastiere; Mireia Gascon; Davide Gori; Hazel Inskip; Pernille S Larsen; Monique Mommers; Anne-Marie Nybo Andersen; John Penders; Maria S Petersen; Katharine Pike; Daniela Porta; Agnes Sonnenschein-van der Voort; Ulrike Steuerwald; Jordi Sunyer; Maties Torrent; Martine Vrijheid; Lorenzo Richiardi; Franca Rusconi

doi:10.1093/ije/dyu260

Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts

Daniela Zugna, Claudia Galassi, Isabella Annesi-Maesano, Nour Baïz, Henrique Barros, Mikel Basterrechea, Sofia Correia, Liesbeth Duijts, Ana Esplugues, Maria Pia Fantini, Francesco Forastiere, Mireia Gascon, Davide Gori, Hazel Inskip, Pernille S Larsen, Monique Mommers, Anne-Marie Nybo Andersen, John Penders, Maria S Petersen, Katharine PikeDaniela Porta, Agnes Sonnenschein-van der Voort, Ulrike Steuerwald, Jordi Sunyer, Maties Torrent, Martine Vrijheid, Lorenzo Richiardi, Franca Rusconi

Section of Social Medicine

41 Citations (Scopus)

Abstract

BACKGROUND: Evidence on the effect of maternal complications in pregnancy on wheezing in offspring is still insufficient.

METHODS: A pooled analysis was performed on individual participant data from fourteen European birth cohorts to assess the relationship between several maternal pregnancy complications and wheezing symptoms in the offspring. Exposures of interest included hypertension and preeclampsia, diabetes, as well as pre-pregnancy overweight (body mass index between 25 and 29.9) and obesity (body mass index ≥ 30) compared with normal weight (body mass index between 18.5 and 24.9). Outcomes included both ever and recurrent wheezing from birth up to 12-24 months of age. Cohort-specific crude and adjusted risk ratios (RR) were calculated using log-binomial regression models and then pooled using a random effects model.

RESULTS: The study included 85509 subjects. Cohort-specific prevalence of ever wheezing varied from 20.0% to 47.3%, and of recurrent wheezing from 3.0% to 14.3%. Adjusted pooled RR for ever and recurrent wheezing were: 1.02 (95% CI: 0.98-1.06) and 1.20 (95% CI: 0.98-1.47) for hypertensive disorders; 1.09 (95% CI: 1.01-1.18) and 1.23 (95% CI: 1.07-1.43) for preeclampsia; 1.04 (95% CI: 0.97-1.13) and 1.24 (95% CI: 0.86-1.79) for diabetes; 1.08 (95% CI: 1.05-1.11) and 1.19 (95% CI: 1.12-1.26) for overweight; 1.12 (95% CI: 1.08-1.17) and 1.16 (95% CI: 0.97-1.39) for obesity. No heterogeneity was found in RR estimates among the cohorts, except for diabetes and recurrent wheezing (P=0.027).

CONCLUSIONS: Preeclampsia, maternal pre-pregnancy overweight and obesity are associated with an increase risk of wheezing in the offspring.

Original language	English
Journal	International Journal of Epidemiology
Volume	44
Issue number	1
Pages (from-to)	199-208
Number of pages	10
ISSN	0300-5771
DOIs	https://doi.org/10.1093/ije/dyu260
Publication status	Published - 1 Feb 2015

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Zugna, D., Galassi, C., Annesi-Maesano, I., Baïz, N., Barros, H., Basterrechea, M., Correia, S., Duijts, L., Esplugues, A., Fantini, M. P., Forastiere, F., Gascon, M., Gori, D., Inskip, H., Larsen, P. S., Mommers, M., Andersen, A-M. N., Penders, J., Petersen, M. S., ... Rusconi, F. (2015). Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts. International Journal of Epidemiology, 44(1), 199-208. https://doi.org/10.1093/ije/dyu260

Zugna, D, Galassi, C, Annesi-Maesano, I, Baïz, N, Barros, H, Basterrechea, M, Correia, S, Duijts, L, Esplugues, A, Fantini, MP, Forastiere, F, Gascon, M, Gori, D, Inskip, H, Larsen, PS, Mommers, M, Andersen, A-MN, Penders, J, Petersen, MS, Pike, K, Porta, D, Sonnenschein-van der Voort, A, Steuerwald, U, Sunyer, J, Torrent, M, Vrijheid, M, Richiardi, L & Rusconi, F 2015, 'Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts', International Journal of Epidemiology, vol. 44, no. 1, pp. 199-208. https://doi.org/10.1093/ije/dyu260

@article{84328b618d3c4e3380e1f8e1ba40ca59,

title = "Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts",

abstract = "BACKGROUND: Evidence on the effect of maternal complications in pregnancy on wheezing in offspring is still insufficient.METHODS: A pooled analysis was performed on individual participant data from fourteen European birth cohorts to assess the relationship between several maternal pregnancy complications and wheezing symptoms in the offspring. Exposures of interest included hypertension and preeclampsia, diabetes, as well as pre-pregnancy overweight (body mass index between 25 and 29.9) and obesity (body mass index ≥ 30) compared with normal weight (body mass index between 18.5 and 24.9). Outcomes included both ever and recurrent wheezing from birth up to 12-24 months of age. Cohort-specific crude and adjusted risk ratios (RR) were calculated using log-binomial regression models and then pooled using a random effects model.RESULTS: The study included 85509 subjects. Cohort-specific prevalence of ever wheezing varied from 20.0% to 47.3%, and of recurrent wheezing from 3.0% to 14.3%. Adjusted pooled RR for ever and recurrent wheezing were: 1.02 (95% CI: 0.98-1.06) and 1.20 (95% CI: 0.98-1.47) for hypertensive disorders; 1.09 (95% CI: 1.01-1.18) and 1.23 (95% CI: 1.07-1.43) for preeclampsia; 1.04 (95% CI: 0.97-1.13) and 1.24 (95% CI: 0.86-1.79) for diabetes; 1.08 (95% CI: 1.05-1.11) and 1.19 (95% CI: 1.12-1.26) for overweight; 1.12 (95% CI: 1.08-1.17) and 1.16 (95% CI: 0.97-1.39) for obesity. No heterogeneity was found in RR estimates among the cohorts, except for diabetes and recurrent wheezing (P=0.027).CONCLUSIONS: Preeclampsia, maternal pre-pregnancy overweight and obesity are associated with an increase risk of wheezing in the offspring.",

author = "Daniela Zugna and Claudia Galassi and Isabella Annesi-Maesano and Nour Ba{\"i}z and Henrique Barros and Mikel Basterrechea and Sofia Correia and Liesbeth Duijts and Ana Esplugues and Fantini, {Maria Pia} and Francesco Forastiere and Mireia Gascon and Davide Gori and Hazel Inskip and Larsen, {Pernille S} and Monique Mommers and Andersen, {Anne-Marie Nybo} and John Penders and Petersen, {Maria S} and Katharine Pike and Daniela Porta and {Sonnenschein-van der Voort}, Agnes and Ulrike Steuerwald and Jordi Sunyer and Maties Torrent and Martine Vrijheid and Lorenzo Richiardi and Franca Rusconi",

year = "2015",

month = feb,

day = "1",

doi = "10.1093/ije/dyu260",

language = "English",

volume = "44",

pages = "199--208",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

number = "1",

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TY - JOUR

T1 - Maternal complications in pregnancy and wheezing in early childhood

T2 - a pooled analysis of 14 birth cohorts

AU - Zugna, Daniela

AU - Galassi, Claudia

AU - Annesi-Maesano, Isabella

AU - Baïz, Nour

AU - Barros, Henrique

AU - Basterrechea, Mikel

AU - Correia, Sofia

AU - Duijts, Liesbeth

AU - Esplugues, Ana

AU - Fantini, Maria Pia

AU - Forastiere, Francesco

AU - Gascon, Mireia

AU - Gori, Davide

AU - Inskip, Hazel

AU - Larsen, Pernille S

AU - Mommers, Monique

AU - Andersen, Anne-Marie Nybo

AU - Penders, John

AU - Petersen, Maria S

AU - Pike, Katharine

AU - Porta, Daniela

AU - Sonnenschein-van der Voort, Agnes

AU - Steuerwald, Ulrike

AU - Sunyer, Jordi

AU - Torrent, Maties

AU - Vrijheid, Martine

AU - Richiardi, Lorenzo

AU - Rusconi, Franca

PY - 2015/2/1

Y1 - 2015/2/1

N2 - BACKGROUND: Evidence on the effect of maternal complications in pregnancy on wheezing in offspring is still insufficient.METHODS: A pooled analysis was performed on individual participant data from fourteen European birth cohorts to assess the relationship between several maternal pregnancy complications and wheezing symptoms in the offspring. Exposures of interest included hypertension and preeclampsia, diabetes, as well as pre-pregnancy overweight (body mass index between 25 and 29.9) and obesity (body mass index ≥ 30) compared with normal weight (body mass index between 18.5 and 24.9). Outcomes included both ever and recurrent wheezing from birth up to 12-24 months of age. Cohort-specific crude and adjusted risk ratios (RR) were calculated using log-binomial regression models and then pooled using a random effects model.RESULTS: The study included 85509 subjects. Cohort-specific prevalence of ever wheezing varied from 20.0% to 47.3%, and of recurrent wheezing from 3.0% to 14.3%. Adjusted pooled RR for ever and recurrent wheezing were: 1.02 (95% CI: 0.98-1.06) and 1.20 (95% CI: 0.98-1.47) for hypertensive disorders; 1.09 (95% CI: 1.01-1.18) and 1.23 (95% CI: 1.07-1.43) for preeclampsia; 1.04 (95% CI: 0.97-1.13) and 1.24 (95% CI: 0.86-1.79) for diabetes; 1.08 (95% CI: 1.05-1.11) and 1.19 (95% CI: 1.12-1.26) for overweight; 1.12 (95% CI: 1.08-1.17) and 1.16 (95% CI: 0.97-1.39) for obesity. No heterogeneity was found in RR estimates among the cohorts, except for diabetes and recurrent wheezing (P=0.027).CONCLUSIONS: Preeclampsia, maternal pre-pregnancy overweight and obesity are associated with an increase risk of wheezing in the offspring.

AB - BACKGROUND: Evidence on the effect of maternal complications in pregnancy on wheezing in offspring is still insufficient.METHODS: A pooled analysis was performed on individual participant data from fourteen European birth cohorts to assess the relationship between several maternal pregnancy complications and wheezing symptoms in the offspring. Exposures of interest included hypertension and preeclampsia, diabetes, as well as pre-pregnancy overweight (body mass index between 25 and 29.9) and obesity (body mass index ≥ 30) compared with normal weight (body mass index between 18.5 and 24.9). Outcomes included both ever and recurrent wheezing from birth up to 12-24 months of age. Cohort-specific crude and adjusted risk ratios (RR) were calculated using log-binomial regression models and then pooled using a random effects model.RESULTS: The study included 85509 subjects. Cohort-specific prevalence of ever wheezing varied from 20.0% to 47.3%, and of recurrent wheezing from 3.0% to 14.3%. Adjusted pooled RR for ever and recurrent wheezing were: 1.02 (95% CI: 0.98-1.06) and 1.20 (95% CI: 0.98-1.47) for hypertensive disorders; 1.09 (95% CI: 1.01-1.18) and 1.23 (95% CI: 1.07-1.43) for preeclampsia; 1.04 (95% CI: 0.97-1.13) and 1.24 (95% CI: 0.86-1.79) for diabetes; 1.08 (95% CI: 1.05-1.11) and 1.19 (95% CI: 1.12-1.26) for overweight; 1.12 (95% CI: 1.08-1.17) and 1.16 (95% CI: 0.97-1.39) for obesity. No heterogeneity was found in RR estimates among the cohorts, except for diabetes and recurrent wheezing (P=0.027).CONCLUSIONS: Preeclampsia, maternal pre-pregnancy overweight and obesity are associated with an increase risk of wheezing in the offspring.

U2 - 10.1093/ije/dyu260

DO - 10.1093/ije/dyu260

M3 - Journal article

C2 - 25626439

SN - 0300-5771

VL - 44

SP - 199

EP - 208

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 1

ER -

Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts

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