MAO-A inhibition profiles of some benzophenone glucosides from Gentiana verna subsp. pontica

Duygu Kaya; Anna Jäger; Funda N Yalçin; Tayfun Ersöz

MAO-A inhibition profiles of some benzophenone glucosides from Gentiana verna subsp. pontica

Duygu Kaya, Anna Jäger, Funda N Yalçin, Tayfun Ersöz

1 Citation (Scopus)

Abstract

Gentiana verna L. subsp. pontica (Soltok.) Hayek, G. pyrenaica L., and G. verna L. subsp. balcanica Pritchard from Turkey were tested for their MAO-A inhibitory effects. A photometric peroxidase linked MAO-A bioassay performed on the H₂O extracts prepared from the methanolic extracts of the title plants revealed the potential effect of G. verna subsp. pontica and three benzophenone glucosides; 2,3′-dihydroxy-4-methoxy-benzophenone-6-O-β- glucopyranoside (1), 2,4,3′,4′-tetrahydroxy-benzophenone-6-O-β- glucopyranoside (maclurin-6-O-β-glucopyranoside) (2) and 2,4,3′-trihydroxy-benzophenone-6-O-β-glucopyranoside (3) isolated from G. verna subsp. pontica. Among the benzophenone glucosides 1 and 2 exhibited significant inhibition of MAO-A (IC₅₀=31.3±4 μM and 41±4.7 μM resp.).

Original language	English
Journal	Natural Product Communications
Volume	9
Issue number	4
Pages (from-to)	505-6
Number of pages	2
ISSN	1934-578X
Publication status	Published - Apr 2014

Keywords

Benzophenones
Gentiana
Glucosides
Monoamine Oxidase
Monoamine Oxidase Inhibitors

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http://www.ncbi.nlm.nih.gov/pubmed/?term=24868869

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title = "MAO-A inhibition profiles of some benzophenone glucosides from Gentiana verna subsp. pontica",

abstract = "Gentiana verna L. subsp. pontica (Soltok.) Hayek, G. pyrenaica L., and G. verna L. subsp. balcanica Pritchard from Turkey were tested for their MAO-A inhibitory effects. A photometric peroxidase linked MAO-A bioassay performed on the H2O extracts prepared from the methanolic extracts of the title plants revealed the potential effect of G. verna subsp. pontica and three benzophenone glucosides; 2,3′-dihydroxy-4-methoxy-benzophenone-6-O-β- glucopyranoside (1), 2,4,3′,4′-tetrahydroxy-benzophenone-6-O-β- glucopyranoside (maclurin-6-O-β-glucopyranoside) (2) and 2,4,3′-trihydroxy-benzophenone-6-O-β-glucopyranoside (3) isolated from G. verna subsp. pontica. Among the benzophenone glucosides 1 and 2 exhibited significant inhibition of MAO-A (IC50=31.3±4 μM and 41±4.7 μM resp.).",

keywords = "Benzophenones, Gentiana, Glucosides, Monoamine Oxidase, Monoamine Oxidase Inhibitors",

author = "Duygu Kaya and Anna J{\"a}ger and Yal{\c c}in, {Funda N} and Tayfun Ers{\"o}z",

year = "2014",

month = apr,

language = "English",

volume = "9",

pages = "505--6",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "Natural Product Inc.",

number = "4",

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TY - JOUR

T1 - MAO-A inhibition profiles of some benzophenone glucosides from Gentiana verna subsp. pontica

AU - Kaya, Duygu

AU - Jäger, Anna

AU - Yalçin, Funda N

AU - Ersöz, Tayfun

PY - 2014/4

Y1 - 2014/4

N2 - Gentiana verna L. subsp. pontica (Soltok.) Hayek, G. pyrenaica L., and G. verna L. subsp. balcanica Pritchard from Turkey were tested for their MAO-A inhibitory effects. A photometric peroxidase linked MAO-A bioassay performed on the H2O extracts prepared from the methanolic extracts of the title plants revealed the potential effect of G. verna subsp. pontica and three benzophenone glucosides; 2,3′-dihydroxy-4-methoxy-benzophenone-6-O-β- glucopyranoside (1), 2,4,3′,4′-tetrahydroxy-benzophenone-6-O-β- glucopyranoside (maclurin-6-O-β-glucopyranoside) (2) and 2,4,3′-trihydroxy-benzophenone-6-O-β-glucopyranoside (3) isolated from G. verna subsp. pontica. Among the benzophenone glucosides 1 and 2 exhibited significant inhibition of MAO-A (IC50=31.3±4 μM and 41±4.7 μM resp.).

AB - Gentiana verna L. subsp. pontica (Soltok.) Hayek, G. pyrenaica L., and G. verna L. subsp. balcanica Pritchard from Turkey were tested for their MAO-A inhibitory effects. A photometric peroxidase linked MAO-A bioassay performed on the H2O extracts prepared from the methanolic extracts of the title plants revealed the potential effect of G. verna subsp. pontica and three benzophenone glucosides; 2,3′-dihydroxy-4-methoxy-benzophenone-6-O-β- glucopyranoside (1), 2,4,3′,4′-tetrahydroxy-benzophenone-6-O-β- glucopyranoside (maclurin-6-O-β-glucopyranoside) (2) and 2,4,3′-trihydroxy-benzophenone-6-O-β-glucopyranoside (3) isolated from G. verna subsp. pontica. Among the benzophenone glucosides 1 and 2 exhibited significant inhibition of MAO-A (IC50=31.3±4 μM and 41±4.7 μM resp.).

KW - Benzophenones

KW - Gentiana

KW - Glucosides

KW - Monoamine Oxidase

KW - Monoamine Oxidase Inhibitors

M3 - Journal article

C2 - 24868869

SN - 1934-578X

VL - 9

SP - 505

EP - 506

JO - Natural Product Communications

JF - Natural Product Communications

IS - 4

ER -

MAO-A inhibition profiles of some benzophenone glucosides from Gentiana verna subsp. pontica

Abstract

Keywords

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