Abstract
Collagen is the predominant structural protein in tendons and ligaments, and can be controlled by hormonal changes. In animals, injections of insulin-like growth factor I (IGF-I) has been shown to increase collagen synthesis in tendons and ligaments and to improve structural tissue healing, but the effect of local IGF-I administration on tendon collagen synthesis in human has not been studied. The purpose of this study was to study whether local injections of IGF-I would have a stimulating effect on tendon collagen synthesis. Twelve healthy nonsmoking men [age 62±1years (mean±SEM), BMI 27±1] participated. Two injections of either human recombinant IGF-I (0.1mL Increlex
| Original language | English |
|---|---|
| Journal | Scandinavian Journal of Medicine & Science in Sports |
| Volume | 23 |
| Issue number | 5 |
| Pages (from-to) | 614-9 |
| Number of pages | 6 |
| ISSN | 0905-7188 |
| DOIs | |
| Publication status | Published - Oct 2013 |
Keywords
- Aged
- Biological Markers
- Collagen
- Collagen Type I
- Denmark
- Double-Blind Method
- Humans
- Injections
- Insulin-Like Growth Factor I
- Male
- Microdialysis
- Middle Aged
- Patellar Ligament
- Sodium Chloride
