Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans

TY - JOUR

T1 - Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans

AU - Hansen, M

AU - Boesen, A

AU - Holm, L

AU - Flyvbjerg, A

AU - Langberg, Henning

AU - Kjaer, M

N1 - © 2012 John Wiley & Sons A/S.

PY - 2013/10

Y1 - 2013/10

N2 - Collagen is the predominant structural protein in tendons and ligaments, and can be controlled by hormonal changes. In animals, injections of insulin-like growth factor I (IGF-I) has been shown to increase collagen synthesis in tendons and ligaments and to improve structural tissue healing, but the effect of local IGF-I administration on tendon collagen synthesis in human has not been studied. The purpose of this study was to study whether local injections of IGF-I would have a stimulating effect on tendon collagen synthesis. Twelve healthy nonsmoking men [age 62±1years (mean±SEM), BMI 27±1] participated. Two injections of either human recombinant IGF-I (0.1mL Increlex

AB - Collagen is the predominant structural protein in tendons and ligaments, and can be controlled by hormonal changes. In animals, injections of insulin-like growth factor I (IGF-I) has been shown to increase collagen synthesis in tendons and ligaments and to improve structural tissue healing, but the effect of local IGF-I administration on tendon collagen synthesis in human has not been studied. The purpose of this study was to study whether local injections of IGF-I would have a stimulating effect on tendon collagen synthesis. Twelve healthy nonsmoking men [age 62±1years (mean±SEM), BMI 27±1] participated. Two injections of either human recombinant IGF-I (0.1mL Increlex

U2 - 10.1111/j.1600-0838.2011.01431.x

DO - 10.1111/j.1600-0838.2011.01431.x

M3 - Journal article

C2 - 22288768

SN - 0905-7188

JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

ER -