Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients: from the Danish 'MALOVA' ovarian cancer study

TY - JOUR

T1 - Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients

T2 - from the Danish 'MALOVA' ovarian cancer study

AU - Heeran, Mel C

AU - Høgdall, Claus K

AU - Kjaer, Susanne K

AU - Christensen, Lise Hanne

AU - Blaakaer, Jan

AU - Christensen, Ib Jarle

AU - Hogdall, Estrid V S

N1 - © 2012 The Authors APMIS © 2012 APMIS.

PY - 2012/10

Y1 - 2012/10

N2 - The primary objective of this study was to assess the expression of cyclin E in tumour tissues from 661 patients with epithelial ovarian tumours. The second was to evaluate whether cyclin E tissue expression levels correlate with clinico-pathological parameters and prognosis of the disease. Using tissue arrays (TA), we analysed the cyclin E expression levels in tissues from 168 women with borderline ovarian tumours (BOT) (147 stage I, 4 stage II, 17 stage III) and 493 Ovarian cancer (OC) patients (127 stage I, 45 stage II, 276 stage III, 45 stage IV). Using a 10% cut-off level for cyclin E overexpression, 20% of the BOTs were positive with a higher proportion of serous than mucinous tumours. Sixty-two per cent of the OCs were positive for cyclin E expression with the highest percentage found in clear cell carcinomas. Results based on univariate and multivariate survival analyses with a 10% cut-off value showed that cyclin E had no independent prognostic value. In conclusion, we found cyclin E expression in tumour tissue to be of limited prognostic value to Danish OC patients.

AB - The primary objective of this study was to assess the expression of cyclin E in tumour tissues from 661 patients with epithelial ovarian tumours. The second was to evaluate whether cyclin E tissue expression levels correlate with clinico-pathological parameters and prognosis of the disease. Using tissue arrays (TA), we analysed the cyclin E expression levels in tissues from 168 women with borderline ovarian tumours (BOT) (147 stage I, 4 stage II, 17 stage III) and 493 Ovarian cancer (OC) patients (127 stage I, 45 stage II, 276 stage III, 45 stage IV). Using a 10% cut-off level for cyclin E overexpression, 20% of the BOTs were positive with a higher proportion of serous than mucinous tumours. Sixty-two per cent of the OCs were positive for cyclin E expression with the highest percentage found in clear cell carcinomas. Results based on univariate and multivariate survival analyses with a 10% cut-off value showed that cyclin E had no independent prognostic value. In conclusion, we found cyclin E expression in tumour tissue to be of limited prognostic value to Danish OC patients.

U2 - 10.1111/j.1600-0463.2012.02913.x

DO - 10.1111/j.1600-0463.2012.02913.x

M3 - Journal article

C2 - 22958293

SN - 0903-465X

VL - 120

SP - 846

EP - 854

JO - APMIS. Supplementum

JF - APMIS. Supplementum

IS - 10

ER -