Liberal transfusion af røde donorblodceller kan øge mortaliteten

Hans-Christian Pommergaard; Astrid Nørgaard; Jakob Burcharth; Trine Stissing; Jacob Rosenberg

Liberal transfusion af røde donorblodceller kan øge mortaliteten

Hans-Christian Pommergaard, Astrid Nørgaard, Jakob Burcharth, Trine Stissing, Jacob Rosenberg

Department of Clinical Medicine

Abstract

In addition to the known adverse effects of red blood cell transfusion, evidence suggests that transfusion with allogeneic red blood cells in itself may increase mortality, risk of infection and even cancer recurrence rates. Among possible mechanisms to explain this effect are transfusion-related immune modulation and storage lesions. However, anaemia may also increase mortality and the risk of anaemia should be balanced against the risks of transfusion. Further properly designed and powered studies are needed to clarify the beneficial and harmful effects of red blood cell transfusion in well-defined patient categories.

Original language	Danish
Journal	Ugeskrift for Læger
Volume	176
Issue number	7
Pages (from-to)	630-633
Number of pages	4
ISSN	0041-5782
Publication status	Published - 2014

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Liberal transfusion af r{\o}de donorblodceller kan {\o}ge mortaliteten",

abstract = "In addition to the known adverse effects of red blood cell transfusion, evidence suggests that transfusion with allogeneic red blood cells in itself may increase mortality, risk of infection and even cancer recurrence rates. Among possible mechanisms to explain this effect are transfusion-related immune modulation and storage lesions. However, anaemia may also increase mortality and the risk of anaemia should be balanced against the risks of transfusion. Further properly designed and powered studies are needed to clarify the beneficial and harmful effects of red blood cell transfusion in well-defined patient categories.",

author = "Hans-Christian Pommergaard and Astrid N{\o}rgaard and Jakob Burcharth and Trine Stissing and Jacob Rosenberg",

year = "2014",

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T1 - Liberal transfusion af røde donorblodceller kan øge mortaliteten

AU - Pommergaard, Hans-Christian

AU - Nørgaard, Astrid

AU - Burcharth, Jakob

AU - Stissing, Trine

AU - Rosenberg, Jacob

PY - 2014

Y1 - 2014

N2 - In addition to the known adverse effects of red blood cell transfusion, evidence suggests that transfusion with allogeneic red blood cells in itself may increase mortality, risk of infection and even cancer recurrence rates. Among possible mechanisms to explain this effect are transfusion-related immune modulation and storage lesions. However, anaemia may also increase mortality and the risk of anaemia should be balanced against the risks of transfusion. Further properly designed and powered studies are needed to clarify the beneficial and harmful effects of red blood cell transfusion in well-defined patient categories.

AB - In addition to the known adverse effects of red blood cell transfusion, evidence suggests that transfusion with allogeneic red blood cells in itself may increase mortality, risk of infection and even cancer recurrence rates. Among possible mechanisms to explain this effect are transfusion-related immune modulation and storage lesions. However, anaemia may also increase mortality and the risk of anaemia should be balanced against the risks of transfusion. Further properly designed and powered studies are needed to clarify the beneficial and harmful effects of red blood cell transfusion in well-defined patient categories.

M3 - Tidsskriftartikel

SN - 0041-5782

VL - 176

SP - 630

EP - 633

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 7

ER -