Keitel Functional Test for patients with rheumatoid arthritis: translation, reliability, validity, and responsiveness.

Bente Holm; S. Jacobsen; H. Skjodt; M. Klarlund; Tim Jensen; Merete Lund Hetland; Mikkel Østergaard; Bente Holm; Soren Jacobsen; Henrik Skjødt; Mette Klarlund; Trine Jensen; Merete Lund Hetland; Mikkel Ostergaard

doi:10.2522/ptj.20070119

Keitel Functional Test for patients with rheumatoid arthritis: translation, reliability, validity, and responsiveness.

Bente Holm, S. Jacobsen, H. Skjodt, M. Klarlund, Tim Jensen, Merete Lund Hetland, Mikkel Østergaard, Bente Holm, Soren Jacobsen, Henrik Skjødt, Mette Klarlund, Trine Jensen, Merete Lund Hetland, Mikkel Ostergaard

8 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: The purpose of this study was to translate the German Keitel Functional Test (KFT) into Danish and test it for reliability, concurrent and predictive validity, and responsiveness in patients with rheumatoid arthritis (RA). METHODS: Translation of the KFT was performed according to international recommendations, and the translated version was tested twice by 2 observers for intraobserver and interobserver reliability, with a 1-week interval between assessments, in 20 patients with RA with stable disease activity. Validity was investigated by studying 2 patient groups: (1) 15 patients with long-lasting (median=6 years) active RA, tested before and after 2, 6, and 14 weeks of anti-tumor necrosis factor alpha (TNF-alpha) inhibitor therapy, and (2) 35 patients with early (median=0.25 year) RA, tested at years 0, 0.5, 1, and 2. Twenty-three patients in the early RA group also were tested at year 7. KFT, conventional clinical and biochemical markers of disease activity, and Health Assessment Questionnaire (HAQ) were used. RESULTS: The translated KFT showed good intraobserver reliability (intraclass correlation coefficients [ICC]=.90 and .95, coefficient of variation [CV]=3.5%) and interobserver reliability (ICC=.99 and .92, CV=3.5%), and the KFT correlated with several measures of disease activity and, most closely, with the HAQ. The KFT was, in contrast to clinical disease activity measures, not sensitive to changes over time. Only baseline KFT data were significantly related to functional changes over a long period of time as measured by the KFT, and only in the early RA group. DISCUSSION AND CONCLUSION: The Danish translation of the KFT showed good reliability, acceptable concurrent validity, very poor responsiveness, and inconclusive results concerning predictive validity. The results of this study do not support the use of the KFT for monitoring function in clinical practice, as an outcome measure in clinical trials, or as a predictor of functional changes.
Udgivelsesdato: 2008-May

Original language	English
Journal	Physical Therapy
Volume	88
Issue number	5
Pages (from-to)	664-78
Number of pages	14
ISSN	0031-9023
DOIs	https://doi.org/10.2522/ptj.20070119 https://doi.org/10.2522/ptj.20070119
Publication status	Published - 2008

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Holm, B., Jacobsen, S., Skjodt, H., Klarlund, M., Jensen, T., Hetland, M. L., Østergaard, M., Holm, B., Jacobsen, S., Skjødt, H., Klarlund, M., Jensen, T., Hetland, M. L., & Ostergaard, M. (2008). Keitel Functional Test for patients with rheumatoid arthritis: translation, reliability, validity, and responsiveness. Physical Therapy, 88(5), 664-78. https://doi.org/10.2522/ptj.20070119, https://doi.org/10.2522/ptj.20070119

Holm, B, Jacobsen, S, Skjodt, H, Klarlund, M, Jensen, T, Hetland, ML , Østergaard, M, Holm, B, Jacobsen, S, Skjødt, H, Klarlund, M, Jensen, T, Hetland, ML & Ostergaard, M 2008, 'Keitel Functional Test for patients with rheumatoid arthritis: translation, reliability, validity, and responsiveness.', Physical Therapy, vol. 88, no. 5, pp. 664-78. https://doi.org/10.2522/ptj.20070119, https://doi.org/10.2522/ptj.20070119

@article{bf0e7150066211deb05e000ea68e967b,

title = "Keitel Functional Test for patients with rheumatoid arthritis: translation, reliability, validity, and responsiveness.",

abstract = "BACKGROUND AND PURPOSE: The purpose of this study was to translate the German Keitel Functional Test (KFT) into Danish and test it for reliability, concurrent and predictive validity, and responsiveness in patients with rheumatoid arthritis (RA). METHODS: Translation of the KFT was performed according to international recommendations, and the translated version was tested twice by 2 observers for intraobserver and interobserver reliability, with a 1-week interval between assessments, in 20 patients with RA with stable disease activity. Validity was investigated by studying 2 patient groups: (1) 15 patients with long-lasting (median=6 years) active RA, tested before and after 2, 6, and 14 weeks of anti-tumor necrosis factor alpha (TNF-alpha) inhibitor therapy, and (2) 35 patients with early (median=0.25 year) RA, tested at years 0, 0.5, 1, and 2. Twenty-three patients in the early RA group also were tested at year 7. KFT, conventional clinical and biochemical markers of disease activity, and Health Assessment Questionnaire (HAQ) were used. RESULTS: The translated KFT showed good intraobserver reliability (intraclass correlation coefficients [ICC]=.90 and .95, coefficient of variation [CV]=3.5%) and interobserver reliability (ICC=.99 and .92, CV=3.5%), and the KFT correlated with several measures of disease activity and, most closely, with the HAQ. The KFT was, in contrast to clinical disease activity measures, not sensitive to changes over time. Only baseline KFT data were significantly related to functional changes over a long period of time as measured by the KFT, and only in the early RA group. DISCUSSION AND CONCLUSION: The Danish translation of the KFT showed good reliability, acceptable concurrent validity, very poor responsiveness, and inconclusive results concerning predictive validity. The results of this study do not support the use of the KFT for monitoring function in clinical practice, as an outcome measure in clinical trials, or as a predictor of functional changes. Udgivelsesdato: 2008-May",

author = "Bente Holm and S. Jacobsen and H. Skjodt and M. Klarlund and Tim Jensen and Hetland, {Merete Lund} and Mikkel {\O}stergaard and Bente Holm and Soren Jacobsen and Henrik Skj{\o}dt and Mette Klarlund and Trine Jensen and Hetland, {Merete Lund} and Mikkel Ostergaard",

note = "Times Cited: 1Proceedings PaperEnglishHolm, BUniv Copenhagen, Hvidovre Hosp, Dept Physiol Therapy, Copenhagen, DenmarkCited References Count: 35296HWAMER PHYSICAL THERAPY ASSOC1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USAALEXANDRIA",

year = "2008",

doi = "10.2522/ptj.20070119",

language = "English",

volume = "88",

pages = "664--78",

journal = "Physical Therapy",

issn = "0031-9023",

publisher = "American Physical Therapy Association",

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TY - JOUR

T1 - Keitel Functional Test for patients with rheumatoid arthritis: translation, reliability, validity, and responsiveness.

AU - Holm, Bente

AU - Jacobsen, S.

AU - Skjodt, H.

AU - Klarlund, M.

AU - Jensen, Tim

AU - Hetland, Merete Lund

AU - Østergaard, Mikkel

AU - Holm, Bente

AU - Jacobsen, Soren

AU - Skjødt, Henrik

AU - Klarlund, Mette

AU - Jensen, Trine

AU - Hetland, Merete Lund

AU - Ostergaard, Mikkel

N1 - Times Cited: 1Proceedings PaperEnglishHolm, BUniv Copenhagen, Hvidovre Hosp, Dept Physiol Therapy, Copenhagen, DenmarkCited References Count: 35296HWAMER PHYSICAL THERAPY ASSOC1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USAALEXANDRIA

PY - 2008

Y1 - 2008

N2 - BACKGROUND AND PURPOSE: The purpose of this study was to translate the German Keitel Functional Test (KFT) into Danish and test it for reliability, concurrent and predictive validity, and responsiveness in patients with rheumatoid arthritis (RA). METHODS: Translation of the KFT was performed according to international recommendations, and the translated version was tested twice by 2 observers for intraobserver and interobserver reliability, with a 1-week interval between assessments, in 20 patients with RA with stable disease activity. Validity was investigated by studying 2 patient groups: (1) 15 patients with long-lasting (median=6 years) active RA, tested before and after 2, 6, and 14 weeks of anti-tumor necrosis factor alpha (TNF-alpha) inhibitor therapy, and (2) 35 patients with early (median=0.25 year) RA, tested at years 0, 0.5, 1, and 2. Twenty-three patients in the early RA group also were tested at year 7. KFT, conventional clinical and biochemical markers of disease activity, and Health Assessment Questionnaire (HAQ) were used. RESULTS: The translated KFT showed good intraobserver reliability (intraclass correlation coefficients [ICC]=.90 and .95, coefficient of variation [CV]=3.5%) and interobserver reliability (ICC=.99 and .92, CV=3.5%), and the KFT correlated with several measures of disease activity and, most closely, with the HAQ. The KFT was, in contrast to clinical disease activity measures, not sensitive to changes over time. Only baseline KFT data were significantly related to functional changes over a long period of time as measured by the KFT, and only in the early RA group. DISCUSSION AND CONCLUSION: The Danish translation of the KFT showed good reliability, acceptable concurrent validity, very poor responsiveness, and inconclusive results concerning predictive validity. The results of this study do not support the use of the KFT for monitoring function in clinical practice, as an outcome measure in clinical trials, or as a predictor of functional changes. Udgivelsesdato: 2008-May

AB - BACKGROUND AND PURPOSE: The purpose of this study was to translate the German Keitel Functional Test (KFT) into Danish and test it for reliability, concurrent and predictive validity, and responsiveness in patients with rheumatoid arthritis (RA). METHODS: Translation of the KFT was performed according to international recommendations, and the translated version was tested twice by 2 observers for intraobserver and interobserver reliability, with a 1-week interval between assessments, in 20 patients with RA with stable disease activity. Validity was investigated by studying 2 patient groups: (1) 15 patients with long-lasting (median=6 years) active RA, tested before and after 2, 6, and 14 weeks of anti-tumor necrosis factor alpha (TNF-alpha) inhibitor therapy, and (2) 35 patients with early (median=0.25 year) RA, tested at years 0, 0.5, 1, and 2. Twenty-three patients in the early RA group also were tested at year 7. KFT, conventional clinical and biochemical markers of disease activity, and Health Assessment Questionnaire (HAQ) were used. RESULTS: The translated KFT showed good intraobserver reliability (intraclass correlation coefficients [ICC]=.90 and .95, coefficient of variation [CV]=3.5%) and interobserver reliability (ICC=.99 and .92, CV=3.5%), and the KFT correlated with several measures of disease activity and, most closely, with the HAQ. The KFT was, in contrast to clinical disease activity measures, not sensitive to changes over time. Only baseline KFT data were significantly related to functional changes over a long period of time as measured by the KFT, and only in the early RA group. DISCUSSION AND CONCLUSION: The Danish translation of the KFT showed good reliability, acceptable concurrent validity, very poor responsiveness, and inconclusive results concerning predictive validity. The results of this study do not support the use of the KFT for monitoring function in clinical practice, as an outcome measure in clinical trials, or as a predictor of functional changes. Udgivelsesdato: 2008-May

U2 - 10.2522/ptj.20070119

DO - 10.2522/ptj.20070119

M3 - Journal article

C2 - 18276936

SN - 0031-9023

VL - 88

SP - 664

EP - 678

JO - Physical Therapy

JF - Physical Therapy

IS - 5

ER -