IP-10 Can Be Measured in Dried Plasma Spots in Patients with Chronic Hepatitis C Infection

TY - JOUR

T1 - IP-10 Can Be Measured in Dried Plasma Spots in Patients with Chronic Hepatitis C Infection

AU - Ruhwald, Morten

AU - Andersen, Ellen Sloth

AU - Christensen, Peer Brehm

AU - Moessner, Belinda Klemmensen

AU - Weis, Nina

PY - 2012/9/14

Y1 - 2012/9/14

N2 - The chemokine IP-10 (CXCL10) is a candidate marker for hepatitis C virus (HCV) fibrosis monitoring. The aim of this proof-of-concept study is to assess if IP-10 measurements from dried plasma spots (DPS) are accurate in HCV-infected patients with either minimal or significant fibrosis. We measured IP-10 levels in plasma and DPS of 21 HCV-infected patients with cirrhosis and 19 patients with no/little fibrosis (determined with FibroScan). Cirrhotic patients had significantly higher levels of IP-10 compared to patients with minimal fibrosis. DPS and plasma measurements of IP-10 are comparable and the correlation was excellent (r(2) = 0.97, p

AB - The chemokine IP-10 (CXCL10) is a candidate marker for hepatitis C virus (HCV) fibrosis monitoring. The aim of this proof-of-concept study is to assess if IP-10 measurements from dried plasma spots (DPS) are accurate in HCV-infected patients with either minimal or significant fibrosis. We measured IP-10 levels in plasma and DPS of 21 HCV-infected patients with cirrhosis and 19 patients with no/little fibrosis (determined with FibroScan). Cirrhotic patients had significantly higher levels of IP-10 compared to patients with minimal fibrosis. DPS and plasma measurements of IP-10 are comparable and the correlation was excellent (r(2) = 0.97, p

U2 - 10.1371/journal.pone.0045181

DO - 10.1371/journal.pone.0045181

M3 - Journal article

C2 - 23024806

SN - 1932-6203

VL - 7

SP - e45181

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 9

ER -