Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study

Marli A Robertson; David L Sigalet; Jens Juul Holst; Jon B Meddings; Julie Wood; Keith A Sharkey

doi:10.1007/s10803-007-0482-1

Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study

Marli A Robertson, David L Sigalet, Jens Juul Holst, Jon B Meddings, Julie Wood, Keith A Sharkey

Endocrinology and Metabolism

34 Citations (Scopus)

Abstract

We measured small intestinal permeability using a lactulose:mannitol sugar permeability test in a group of children with autism, with current or previous gastrointestinal complaints. Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feeding. Results were compared with sibling controls and children without developmental disabilities. We enrolled 14 children with autism, 7 developmentally normal siblings of these children and 8 healthy, developmentally normal, unrelated children. Our study did not detect differences in these measures of gastrointestinal function in a group of children with autism.

Original language	English
Journal	Journal of Autism and Developmental Disorders
Volume	38
Issue number	6
Pages (from-to)	1066-71
Number of pages	6
ISSN	0162-3257
DOIs	https://doi.org/10.1007/s10803-007-0482-1
Publication status	Published - Jul 2008

Keywords

Autistic Disorder
Child
Child, Preschool
Female
Glucagon-Like Peptide 2
Humans
Intestinal Absorption
Intestine, Small
Lactulose
Male
Mannitol
Pilot Projects
Reference Values
Satiety Response

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10.1007/s10803-007-0482-1

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title = "Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study",

abstract = "We measured small intestinal permeability using a lactulose:mannitol sugar permeability test in a group of children with autism, with current or previous gastrointestinal complaints. Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feeding. Results were compared with sibling controls and children without developmental disabilities. We enrolled 14 children with autism, 7 developmentally normal siblings of these children and 8 healthy, developmentally normal, unrelated children. Our study did not detect differences in these measures of gastrointestinal function in a group of children with autism.",

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T2 - a controlled pilot study

AU - Robertson, Marli A

AU - Sigalet, David L

AU - Holst, Jens Juul

AU - Meddings, Jon B

AU - Wood, Julie

AU - Sharkey, Keith A

PY - 2008/7

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N2 - We measured small intestinal permeability using a lactulose:mannitol sugar permeability test in a group of children with autism, with current or previous gastrointestinal complaints. Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feeding. Results were compared with sibling controls and children without developmental disabilities. We enrolled 14 children with autism, 7 developmentally normal siblings of these children and 8 healthy, developmentally normal, unrelated children. Our study did not detect differences in these measures of gastrointestinal function in a group of children with autism.

AB - We measured small intestinal permeability using a lactulose:mannitol sugar permeability test in a group of children with autism, with current or previous gastrointestinal complaints. Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feeding. Results were compared with sibling controls and children without developmental disabilities. We enrolled 14 children with autism, 7 developmentally normal siblings of these children and 8 healthy, developmentally normal, unrelated children. Our study did not detect differences in these measures of gastrointestinal function in a group of children with autism.

KW - Autistic Disorder

KW - Child

KW - Child, Preschool

KW - Female

KW - Glucagon-Like Peptide 2

KW - Humans

KW - Intestinal Absorption

KW - Intestine, Small

KW - Lactulose

KW - Male

KW - Mannitol

KW - Pilot Projects

KW - Reference Values

KW - Satiety Response

U2 - 10.1007/s10803-007-0482-1

DO - 10.1007/s10803-007-0482-1

M3 - Journal article

C2 - 18311517

SN - 0162-3257

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JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

IS - 6

ER -

Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study

Abstract

Keywords

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