Abstract
Integrin engagement stimulates the activity of numerous signaling molecules, including the Rho family of GTPases, tyrosine phosphatases, cAMP-dependent protein kinase and protein kinase C, and stimulates production of PtdIns(4,5)P2. Integrins promote actin assembly via the recruitment of molecules that directly activate the actin polymerization machinery or physically link it to sites of cell adhesion.
| Original language | English |
|---|---|
| Journal | Current Opinion in Cell Biology |
| Volume | 15 |
| Issue number | 5 |
| Pages (from-to) | 572-82 |
| Number of pages | 11 |
| ISSN | 0955-0674 |
| Publication status | Published - Oct 2003 |
| Externally published | Yes |
Keywords
- Actins/metabolism
- Animals
- Cyclic AMP-Dependent Protein Kinases
- Cytoskeleton/metabolism
- Enzyme Activation/physiology
- Humans
- Integrins/metabolism
- Phosphatidylinositol 4,5-Diphosphate
- Phosphatidylinositol Phosphates/metabolism
- Protein Kinase C/metabolism
- Protein Tyrosine Phosphatases/metabolism
- Protein-Serine-Threonine Kinases/metabolism
- Signal Transduction/physiology
- cdc42 GTP-Binding Protein/metabolism
- rac GTP-Binding Proteins/metabolism
- rho GTP-Binding Proteins/metabolism