In Vivo Anomalous Diffusion and Weak Ergodicity Breaking of Lipid Granules

TY - JOUR

T1 - In Vivo Anomalous Diffusion and Weak Ergodicity Breaking of Lipid Granules

AU - Jeon, Jae-Hyung

AU - Tejedor, V.

AU - Barkai, Eli

AU - Selhuber-Unkel, Christine Johanna M

AU - Oddershede, Lene Broeng

AU - Berg-Sørensen, K.

AU - Metzler, Ralf

PY - 2011/1/25

Y1 - 2011/1/25

N2 - Combining extensive single particle tracking microscopy data of endogenous lipid granules in living fission yeast cells with analytical results we show evidence for anomalous diffusion and weak ergodicity breaking. Namely we demonstrate that at short times the granules perform subdiffusion according to the laws of continuous time random walk theory. The associated violation of ergodicity leads to a characteristic turnover between two scaling regimes of the time averaged mean squared displacement. At longer times the granule motion is consistent with fractional Brownian motion.

AB - Combining extensive single particle tracking microscopy data of endogenous lipid granules in living fission yeast cells with analytical results we show evidence for anomalous diffusion and weak ergodicity breaking. Namely we demonstrate that at short times the granules perform subdiffusion according to the laws of continuous time random walk theory. The associated violation of ergodicity leads to a characteristic turnover between two scaling regimes of the time averaged mean squared displacement. At longer times the granule motion is consistent with fractional Brownian motion.

U2 - 10.1103/PhysRevLett.106.048103

DO - 10.1103/PhysRevLett.106.048103

M3 - Journal article

C2 - 21405366

SN - 0031-9007

VL - 106

SP - 048103

JO - Physical Review Letters

JF - Physical Review Letters

IS - 4

ER -