In vitro assessment of recombinant, mutant immunoglobulin G anti-D devoid of hemolytic activity for treatment of ongoing hemolytic disease of the fetus and newborn

Leif K Nielsen; Trine H Green; Inger Sandlie; Terje E Michaelsen; Morten Hanefeld Dziegiel

doi:10.1111/j.1537-2995.2007.01474.x

In vitro assessment of recombinant, mutant immunoglobulin G anti-D devoid of hemolytic activity for treatment of ongoing hemolytic disease of the fetus and newborn

Leif K Nielsen, Trine H Green, Inger Sandlie, Terje E Michaelsen, Morten Hanefeld Dziegiel

Department of Clinical Medicine

7 Citations (Scopus)

Abstract

A specific treatment for ongoing hemolytic disease of the fetus and newborn (HDFN) due to anti-D would be very attractive. One approach could be administration to the mother of nonhemolytic anti-D, which by crossing the placenta can block the binding of hemolytic maternal anti-D.

Original language	English
Journal	Transfusion
Volume	48
Issue number	1
Pages (from-to)	12-9
Number of pages	8
ISSN	0041-1132
DOIs	https://doi.org/10.1111/j.1537-2995.2007.01474.x
Publication status	Published - 1 Jan 2008

Keywords

Animals
Antibodies, Anti-Idiotypic
Antibody-Dependent Cell Cytotoxicity
CHO Cells
Chemiluminescent Measurements
Cricetinae
Cricetulus
Erythroblastosis, Fetal
Female
Hemolysis
Humans
Immunoglobulin G
Immunotherapy
Monocytes
Mutation
Recombinant Proteins
Respiratory Burst
Rho(D) Immune Globulin

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10.1111/j.1537-2995.2007.01474.x

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title = "In vitro assessment of recombinant, mutant immunoglobulin G anti-D devoid of hemolytic activity for treatment of ongoing hemolytic disease of the fetus and newborn",

abstract = "A specific treatment for ongoing hemolytic disease of the fetus and newborn (HDFN) due to anti-D would be very attractive. One approach could be administration to the mother of nonhemolytic anti-D, which by crossing the placenta can block the binding of hemolytic maternal anti-D.",

keywords = "Animals, Antibodies, Anti-Idiotypic, Antibody-Dependent Cell Cytotoxicity, CHO Cells, Chemiluminescent Measurements, Cricetinae, Cricetulus, Erythroblastosis, Fetal, Female, Hemolysis, Humans, Immunoglobulin G, Immunotherapy, Monocytes, Mutation, Recombinant Proteins, Respiratory Burst, Rho(D) Immune Globulin",

author = "Nielsen, {Leif K} and Green, {Trine H} and Inger Sandlie and Michaelsen, {Terje E} and Dziegiel, {Morten Hanefeld}",

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T1 - In vitro assessment of recombinant, mutant immunoglobulin G anti-D devoid of hemolytic activity for treatment of ongoing hemolytic disease of the fetus and newborn

AU - Nielsen, Leif K

AU - Green, Trine H

AU - Sandlie, Inger

AU - Michaelsen, Terje E

AU - Dziegiel, Morten Hanefeld

PY - 2008/1/1

Y1 - 2008/1/1

N2 - A specific treatment for ongoing hemolytic disease of the fetus and newborn (HDFN) due to anti-D would be very attractive. One approach could be administration to the mother of nonhemolytic anti-D, which by crossing the placenta can block the binding of hemolytic maternal anti-D.

AB - A specific treatment for ongoing hemolytic disease of the fetus and newborn (HDFN) due to anti-D would be very attractive. One approach could be administration to the mother of nonhemolytic anti-D, which by crossing the placenta can block the binding of hemolytic maternal anti-D.

KW - Animals

KW - Antibodies, Anti-Idiotypic

KW - Antibody-Dependent Cell Cytotoxicity

KW - CHO Cells

KW - Chemiluminescent Measurements

KW - Cricetinae

KW - Cricetulus

KW - Erythroblastosis, Fetal

KW - Female

KW - Hemolysis

KW - Humans

KW - Immunoglobulin G

KW - Immunotherapy

KW - Monocytes

KW - Mutation

KW - Recombinant Proteins

KW - Respiratory Burst

KW - Rho(D) Immune Globulin

U2 - 10.1111/j.1537-2995.2007.01474.x

DO - 10.1111/j.1537-2995.2007.01474.x

M3 - Journal article

C2 - 17764508

SN - 0041-1132

VL - 48

SP - 12

EP - 19

JO - Transfusion

JF - Transfusion

IS - 1

ER -

In vitro assessment of recombinant, mutant immunoglobulin G anti-D devoid of hemolytic activity for treatment of ongoing hemolytic disease of the fetus and newborn

Abstract

Keywords

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