Hypochlorite-induced oxidation of proteins in plasma: formation of chloramines and nitrogen-centred radicals and their role in protein fragmentation

Medicine & Life Sciences

• 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 7%
• Amines 5%
• Blood Proteins 49%
• chloramine 8%
• Chloramines 100%
• Enzymes 2%
• Hypochlorous Acid 79%
• Lysine 4%
• Methionine 10%
• Nitrogen 54%
• Oxidants 5%
• Peroxidase 4%
• Phagocytes 5%
• Polyacrylamide Gel Electrophoresis 4%
• Proteins 20%
• Proteolysis 4%
• Spin Trapping 7%
• thionitrobenzoic acid 10%
• Uric Acid 10%

Chemical Compounds

• Acid 2%
• Adduct 4%
• Amine 4%
• Ascorbate 15%
• Chloramine 78%
• Compound Mobility 5%
• Electron Spin 5%
• Fragmentation 45%
• Hypochlorite 59%
• Lysine 6%
• Methionine 14%
• Oxidation Reaction 24%
• Plasma 34%
• Protein 22%
• Spin Trapping 8%
• Trolox 8%