Histone methyltransferases in cancer

Mareike Albert; Kristian Helin

doi:10.1016/j.semcdb.2009.10.007

Histone methyltransferases in cancer

Mareike Albert, Kristian Helin

217 Citations (Scopus)

Abstract

Cancer is perceived as a heterogeneous group of diseases that is characterized by aberrant patterns of gene expression. In the last decade, an increasing amount of data has pointed to a key role for epigenetic alterations in human cancer. In this review, we focus on a subclass of epigenetic regulators, namely histone methyltransferases (HMTs). Several HMTs have been linked to different types of cancer; however, in most cases we only have limited knowledge regarding the molecular mechanisms by which the HMTs contribute to disease development. We summarize the current knowledge regarding some of the best-validated examples of HMTs contributing to tumorigenesis and discuss their potential mechanisms of action.

Original language	English
Journal	Seminars in Cell and Developmental Biology
Volume	21
Issue number	2
Pages (from-to)	209-20
Number of pages	11
ISSN	1084-9521
DOIs	https://doi.org/10.1016/j.semcdb.2009.10.007
Publication status	Published - Apr 2009

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10.1016/j.semcdb.2009.10.007

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abstract = "Cancer is perceived as a heterogeneous group of diseases that is characterized by aberrant patterns of gene expression. In the last decade, an increasing amount of data has pointed to a key role for epigenetic alterations in human cancer. In this review, we focus on a subclass of epigenetic regulators, namely histone methyltransferases (HMTs). Several HMTs have been linked to different types of cancer; however, in most cases we only have limited knowledge regarding the molecular mechanisms by which the HMTs contribute to disease development. We summarize the current knowledge regarding some of the best-validated examples of HMTs contributing to tumorigenesis and discuss their potential mechanisms of action.",

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Histone methyltransferases in cancer

Abstract

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