Highly fluorescent benzofuran derivatives of the GFP chromophore

Mikkel Andreas Christensen; Karsten Stein Jennum; Peter Bæch Abrahamsen; Eduardo Antonio Della Pia; Kasper Lincke Rue; Søren Lindbæk Broman; David Bo Nygaard; Andrew Bond; Mogens Brøndsted Nielsen

doi:10.1039/c2ra21380j

Highly fluorescent benzofuran derivatives of the GFP chromophore

Mikkel Andreas Christensen, Karsten Stein Jennum, Peter Bæch Abrahamsen, Eduardo Antonio Della Pia, Kasper Lincke Rue, Søren Lindbæk Broman, David Bo Nygaard, Andrew Bond, Mogens Brøndsted Nielsen

Department of Chemistry

9 Citations (Scopus)

Abstract

Intramolecular cyclization reactions of Green Fluorescent Protein chromophores (GFPc) containing an arylethynyl ortho-substituent at the phenol ring provide new aryl-substituted benzofuran derivatives of the GFPc. Some of these heteroaromatic compounds exhibit significantly enhanced fluorescence at red-shifted emission wavelengths relative to the parent GFPc structure.

Original language	English
Journal	RSC Advances
Volume	2
Issue number	22
Pages (from-to)	8243-8249
Number of pages	7
ISSN	2046-2069
DOIs	https://doi.org/10.1039/c2ra21380j
Publication status	Published - 28 Sept 2012

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10.1039/c2ra21380j

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title = "Highly fluorescent benzofuran derivatives of the GFP chromophore",

abstract = "Intramolecular cyclization reactions of Green Fluorescent Protein chromophores (GFPc) containing an arylethynyl ortho-substituent at the phenol ring provide new aryl-substituted benzofuran derivatives of the GFPc. Some of these heteroaromatic compounds exhibit significantly enhanced fluorescence at red-shifted emission wavelengths relative to the parent GFPc structure.",

author = "Christensen, {Mikkel Andreas} and Jennum, {Karsten Stein} and Abrahamsen, {Peter B{\ae}ch} and {Della Pia}, {Eduardo Antonio} and Rue, {Kasper Lincke} and Broman, {S{\o}ren Lindb{\ae}k} and Nygaard, {David Bo} and Andrew Bond and Nielsen, {Mogens Br{\o}ndsted}",

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AU - Christensen, Mikkel Andreas

AU - Jennum, Karsten Stein

AU - Abrahamsen, Peter Bæch

AU - Della Pia, Eduardo Antonio

AU - Rue, Kasper Lincke

AU - Broman, Søren Lindbæk

AU - Nygaard, David Bo

AU - Bond, Andrew

AU - Nielsen, Mogens Brøndsted

PY - 2012/9/28

Y1 - 2012/9/28

N2 - Intramolecular cyclization reactions of Green Fluorescent Protein chromophores (GFPc) containing an arylethynyl ortho-substituent at the phenol ring provide new aryl-substituted benzofuran derivatives of the GFPc. Some of these heteroaromatic compounds exhibit significantly enhanced fluorescence at red-shifted emission wavelengths relative to the parent GFPc structure.

AB - Intramolecular cyclization reactions of Green Fluorescent Protein chromophores (GFPc) containing an arylethynyl ortho-substituent at the phenol ring provide new aryl-substituted benzofuran derivatives of the GFPc. Some of these heteroaromatic compounds exhibit significantly enhanced fluorescence at red-shifted emission wavelengths relative to the parent GFPc structure.

U2 - 10.1039/c2ra21380j

DO - 10.1039/c2ra21380j

M3 - Journal article

SN - 2046-2069

VL - 2

SP - 8243

EP - 8249

JO - RSC Advances

JF - RSC Advances

IS - 22

ER -

Highly fluorescent benzofuran derivatives of the GFP chromophore

Abstract

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