Genome sequence of the Brown Norway rat yields insights into mammalian evolution

Richard A Gibbs; George M Weinstock; Michael L Metzker; Donna M Muzny; Erica J Sodergren; Steven Scherer; Graham Scott; David Steffen; Kim C Worley; Paula E Burch; Geoffrey Okwuonu; Sandra Hines; Lora Lewis; Christine DeRamo; Oliver Delgado; Shannon Dugan-Rocha; George Miner; Margaret Morgan; Alicia Hawes; Rachel Gill; null Celera; Robert A Holt; Mark D Adams; Peter G Amanatides; Holly Baden-Tillson; Mary Barnstead; Soo Chin; Cheryl A Evans; Steve Ferriera; Carl Fosler; Anna Glodek; Zhiping Gu; Don Jennings; Cheryl L Kraft; Trixie Nguyen; Cynthia M Pfannkoch; Cynthia Sitter; Granger G Sutton; J Craig Venter; Trevor Woodage; Douglas Smith; Hong-Mei Lee; Erik Gustafson; Patrick Cahill; Arnold Kana; Lynn Doucette-Stamm; Keith Weinstock; Kim Fechtel; Robert B Weiss; Manimozhiyan Arumugam; Rat Genome Sequencing Project Consortium

doi:10.1038/nature02426

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

Richard A Gibbs, George M Weinstock, Michael L Metzker, Donna M Muzny, Erica J Sodergren, Steven Scherer, Graham Scott, David Steffen, Kim C Worley, Paula E Burch, Geoffrey Okwuonu, Sandra Hines, Lora Lewis, Christine DeRamo, Oliver Delgado, Shannon Dugan-Rocha, George Miner, Margaret Morgan, Alicia Hawes, Rachel GillCelera, Robert A Holt, Mark D Adams, Peter G Amanatides, Holly Baden-Tillson, Mary Barnstead, Soo Chin, Cheryl A Evans, Steve Ferriera, Carl Fosler, Anna Glodek, Zhiping Gu, Don Jennings, Cheryl L Kraft, Trixie Nguyen, Cynthia M Pfannkoch, Cynthia Sitter, Granger G Sutton, J Craig Venter, Trevor Woodage, Douglas Smith, Hong-Mei Lee, Erik Gustafson, Patrick Cahill, Arnold Kana, Lynn Doucette-Stamm, Keith Weinstock, Kim Fechtel, Robert B Weiss, Manimozhiyan Arumugam, Rat Genome Sequencing Project Consortium

1522 Citations (Scopus)

Abstract

The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.

Original language	English
Journal	Nature
Volume	428
Issue number	6982
Pages (from-to)	493-521
Number of pages	29
DOIs	https://doi.org/10.1038/nature02426
Publication status	Published - 2004

Keywords

Animals
Base Composition
Centromere
Chromosomes, Mammalian
CpG Islands
DNA Transposable Elements
DNA, Mitochondrial
Evolution, Molecular
Gene Duplication
Genome
Genomics
Humans
Introns
Male
Mice
Models, Molecular
Mutagenesis
Polymorphism, Single Nucleotide
RNA Splice Sites
RNA, Untranslated
Rats
Rats, Inbred BN
Regulatory Sequences, Nucleic Acid
Retroelements
Sequence Analysis, DNA
Telomere

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nature02426

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Gibbs, R. A., Weinstock, G. M., Metzker, M. L., Muzny, D. M., Sodergren, E. J., Scherer, S., Scott, G., Steffen, D., Worley, K. C., Burch, P. E., Okwuonu, G., Hines, S., Lewis, L., DeRamo, C., Delgado, O., Dugan-Rocha, S., Miner, G., Morgan, M., Hawes, A., ... Rat Genome Sequencing Project Consortium (2004). Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature, 428(6982), 493-521. https://doi.org/10.1038/nature02426

Gibbs, RA, Weinstock, GM, Metzker, ML, Muzny, DM, Sodergren, EJ, Scherer, S, Scott, G, Steffen, D, Worley, KC, Burch, PE, Okwuonu, G, Hines, S, Lewis, L, DeRamo, C, Delgado, O, Dugan-Rocha, S, Miner, G, Morgan, M, Hawes, A, Gill, R, Celera, Holt, RA, Adams, MD, Amanatides, PG, Baden-Tillson, H, Barnstead, M, Chin, S, Evans, CA, Ferriera, S, Fosler, C, Glodek, A, Gu, Z, Jennings, D, Kraft, CL, Nguyen, T, Pfannkoch, CM, Sitter, C, Sutton, GG, Venter, JC, Woodage, T, Smith, D, Lee, H-M, Gustafson, E, Cahill, P, Kana, A, Doucette-Stamm, L, Weinstock, K, Fechtel, K, Weiss, RB, Arumugam, M & Rat Genome Sequencing Project Consortium 2004, 'Genome sequence of the Brown Norway rat yields insights into mammalian evolution', Nature, vol. 428, no. 6982, pp. 493-521. https://doi.org/10.1038/nature02426

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abstract = "The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.",

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AU - Gibbs, Richard A

AU - Weinstock, George M

AU - Metzker, Michael L

AU - Muzny, Donna M

AU - Sodergren, Erica J

AU - Scherer, Steven

AU - Scott, Graham

AU - Steffen, David

AU - Worley, Kim C

AU - Burch, Paula E

AU - Okwuonu, Geoffrey

AU - Hines, Sandra

AU - Lewis, Lora

AU - DeRamo, Christine

AU - Delgado, Oliver

AU - Dugan-Rocha, Shannon

AU - Miner, George

AU - Morgan, Margaret

AU - Hawes, Alicia

AU - Gill, Rachel

AU - Celera, null

AU - Holt, Robert A

AU - Adams, Mark D

AU - Amanatides, Peter G

AU - Baden-Tillson, Holly

AU - Barnstead, Mary

AU - Chin, Soo

AU - Evans, Cheryl A

AU - Ferriera, Steve

AU - Fosler, Carl

AU - Glodek, Anna

AU - Gu, Zhiping

AU - Jennings, Don

AU - Kraft, Cheryl L

AU - Nguyen, Trixie

AU - Pfannkoch, Cynthia M

AU - Sitter, Cynthia

AU - Sutton, Granger G

AU - Venter, J Craig

AU - Woodage, Trevor

AU - Smith, Douglas

AU - Lee, Hong-Mei

AU - Gustafson, Erik

AU - Cahill, Patrick

AU - Kana, Arnold

AU - Doucette-Stamm, Lynn

AU - Weinstock, Keith

AU - Fechtel, Kim

AU - Weiss, Robert B

AU - Arumugam, Manimozhiyan

AU - Rat Genome Sequencing Project Consortium

PY - 2004

Y1 - 2004

N2 - The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.

AB - The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.

KW - Animals

KW - Base Composition

KW - Centromere

KW - Chromosomes, Mammalian

KW - CpG Islands

KW - DNA Transposable Elements

KW - DNA, Mitochondrial

KW - Evolution, Molecular

KW - Gene Duplication

KW - Genome

KW - Genomics

KW - Humans

KW - Introns

KW - Male

KW - Mice

KW - Models, Molecular

KW - Mutagenesis

KW - Polymorphism, Single Nucleotide

KW - RNA Splice Sites

KW - RNA, Untranslated

KW - Rats

KW - Rats, Inbred BN

KW - Regulatory Sequences, Nucleic Acid

KW - Retroelements

KW - Sequence Analysis, DNA

KW - Telomere

U2 - 10.1038/nature02426

DO - 10.1038/nature02426

M3 - Journal article

C2 - 15057822

SN - 0028-0836

VL - 428

SP - 493

EP - 521

JO - Nature

JF - Nature

IS - 6982

ER -

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

Abstract

Keywords

UN SDGs

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