Genome organization and expression of the rat ACBP gene family

S Mandrup; P H Andreasen; J Knudsen; K Kristiansen

doi:10.1007/BF01076475

Genome organization and expression of the rat ACBP gene family

S Mandrup, P H Andreasen, J Knudsen, K Kristiansen

8 Citations (Scopus)

Abstract

Acyl-CoA-Binding Protein (ACBP)/Diazepam-Binding Inhibitor (DBI) is a 10 kD protein which has been implicated in a surprisingly large number of biochemical functions. We have unambiguously demonstrated that ACBP binds acyl-CoA esters with high affinity and in vivo functions as an acyl-CoA ester pool former. We have molecularly cloned and characterized the rat ACBP gene family which comprises one expressed and four processed pseudogenes. One of these was shown to exist in two allelic forms. A comprehensive computer-aided analysis of the promoter region of the expressed ACBP gene revealed that it exhibits all the hallmarks of typical housekeeping genes. In addition, the promoter region harbors a number of potential tissue specific cis-acting elements that may in part regulate the level of ACBP expression in specialized cells.

Original language	English
Journal	Molecular and Cellular Biochemistry
Volume	123
Issue number	1-2
Pages (from-to)	55-61
Number of pages	6
ISSN	0300-8177
DOIs	https://doi.org/10.1007/BF01076475
Publication status	Published - 1993
Externally published	Yes

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title = "Genome organization and expression of the rat ACBP gene family",

abstract = "Acyl-CoA-Binding Protein (ACBP)/Diazepam-Binding Inhibitor (DBI) is a 10 kD protein which has been implicated in a surprisingly large number of biochemical functions. We have unambiguously demonstrated that ACBP binds acyl-CoA esters with high affinity and in vivo functions as an acyl-CoA ester pool former. We have molecularly cloned and characterized the rat ACBP gene family which comprises one expressed and four processed pseudogenes. One of these was shown to exist in two allelic forms. A comprehensive computer-aided analysis of the promoter region of the expressed ACBP gene revealed that it exhibits all the hallmarks of typical housekeeping genes. In addition, the promoter region harbors a number of potential tissue specific cis-acting elements that may in part regulate the level of ACBP expression in specialized cells.",

author = "S Mandrup and Andreasen, {P H} and J Knudsen and K Kristiansen",

note = "Keywords: Acyl Coenzyme A; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA; Diazepam Binding Inhibitor; Gene Expression; Genome; Molecular Sequence Data; Multigene Family; Promoter Regions, Genetic; Pseudogenes; Rats; Rats, Sprague-Dawley; Sequence Alignment",

year = "1993",

doi = "10.1007/BF01076475",

language = "English",

volume = "123",

pages = "55--61",

journal = "Molecular and Cellular Biochemistry",

issn = "0300-8177",

publisher = "Springer",

number = "1-2",

}

TY - JOUR

T1 - Genome organization and expression of the rat ACBP gene family

AU - Mandrup, S

AU - Andreasen, P H

AU - Knudsen, J

AU - Kristiansen, K

N1 - Keywords: Acyl Coenzyme A; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA; Diazepam Binding Inhibitor; Gene Expression; Genome; Molecular Sequence Data; Multigene Family; Promoter Regions, Genetic; Pseudogenes; Rats; Rats, Sprague-Dawley; Sequence Alignment

PY - 1993

Y1 - 1993

N2 - Acyl-CoA-Binding Protein (ACBP)/Diazepam-Binding Inhibitor (DBI) is a 10 kD protein which has been implicated in a surprisingly large number of biochemical functions. We have unambiguously demonstrated that ACBP binds acyl-CoA esters with high affinity and in vivo functions as an acyl-CoA ester pool former. We have molecularly cloned and characterized the rat ACBP gene family which comprises one expressed and four processed pseudogenes. One of these was shown to exist in two allelic forms. A comprehensive computer-aided analysis of the promoter region of the expressed ACBP gene revealed that it exhibits all the hallmarks of typical housekeeping genes. In addition, the promoter region harbors a number of potential tissue specific cis-acting elements that may in part regulate the level of ACBP expression in specialized cells.

AB - Acyl-CoA-Binding Protein (ACBP)/Diazepam-Binding Inhibitor (DBI) is a 10 kD protein which has been implicated in a surprisingly large number of biochemical functions. We have unambiguously demonstrated that ACBP binds acyl-CoA esters with high affinity and in vivo functions as an acyl-CoA ester pool former. We have molecularly cloned and characterized the rat ACBP gene family which comprises one expressed and four processed pseudogenes. One of these was shown to exist in two allelic forms. A comprehensive computer-aided analysis of the promoter region of the expressed ACBP gene revealed that it exhibits all the hallmarks of typical housekeeping genes. In addition, the promoter region harbors a number of potential tissue specific cis-acting elements that may in part regulate the level of ACBP expression in specialized cells.

U2 - 10.1007/BF01076475

DO - 10.1007/BF01076475

M3 - Journal article

C2 - 8232269

SN - 0300-8177

VL - 123

SP - 55

EP - 61

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

IS - 1-2

ER -

Genome organization and expression of the rat ACBP gene family

Abstract

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