Geminin: a major DNA replication safeguard in higher eukaryotes.

TY - JOUR

T1 - Geminin: a major DNA replication safeguard in higher eukaryotes.

AU - Melixetian, Marina

AU - Helin, Kristian

N1 - Keywords: Animals; Cell Cycle Proteins; DNA Replication; Eukaryotic Cells; Humans

PY - 2004

Y1 - 2004

N2 - Eukaryotes have evolved multiple mechanisms to restrict DNA replication to once per cell cycle. These mechanisms prevent relicensing of origins of replication after initiation of DNA replication in S phase until the end of mitosis. Most of our knowledge of mechanisms controlling prereplication complex (preRC) formation are based on studies from yeast and Xenopus, while much less is known for mammalian cells. Here we discuss our recent data demonstrating that Geminin is required for preventing rereplication in human normal and cancer cells.

AB - Eukaryotes have evolved multiple mechanisms to restrict DNA replication to once per cell cycle. These mechanisms prevent relicensing of origins of replication after initiation of DNA replication in S phase until the end of mitosis. Most of our knowledge of mechanisms controlling prereplication complex (preRC) formation are based on studies from yeast and Xenopus, while much less is known for mammalian cells. Here we discuss our recent data demonstrating that Geminin is required for preventing rereplication in human normal and cancer cells.

M3 - Review

C2 - 15280663

SN - 1538-4101

VL - 3

SP - 1002

EP - 1004

JO - Cell Cycle

JF - Cell Cycle

IS - 8

ER -