Galectin-3 guides intracellular trafficking of some human serotransferrin glycoforms

TY - JOUR

T1 - Galectin-3 guides intracellular trafficking of some human serotransferrin glycoforms

AU - Carlsson, Carl Michael

AU - Bengtson, Per

AU - Cucak, Helena

AU - Leffler, Hakon

PY - 2013/9/27

Y1 - 2013/9/27

N2 - Background: Transferrin has two N-glycans but their biological function remains unknown. Results: About 5% of human serotransferrin glycoforms bind galectin-3 and are targeted to a different endocytic pathway. Conclusion: Transferrin glycosylation may mediate a previously unrecognized level of physiological regulation. Significance: This is the first evidence that different molecular forms of transferrin, besides iron loading, may have different cellular function.

AB - Background: Transferrin has two N-glycans but their biological function remains unknown. Results: About 5% of human serotransferrin glycoforms bind galectin-3 and are targeted to a different endocytic pathway. Conclusion: Transferrin glycosylation may mediate a previously unrecognized level of physiological regulation. Significance: This is the first evidence that different molecular forms of transferrin, besides iron loading, may have different cellular function.

U2 - 10.1074/jbc.M113.487793

DO - 10.1074/jbc.M113.487793

M3 - Journal article

C2 - 23926108

SN - 0021-9258

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

ER -