GABA, a natural immunomodulator of T lymphocytes

Helen Bjurstöm; Junyang Wang; Ida Ericsson; Martin Bengtsson; Yawei Liu; Suresh Kumar-Mendu; Shohreh Issazadeh-Navikas; Bryndis Birnir

doi:10.1016/j.jneuroim.2008.08.017

GABA, a natural immunomodulator of T lymphocytes

Helen Bjurstöm, Junyang Wang, Ida Ericsson, Martin Bengtsson, Yawei Liu, Suresh Kumar-Mendu, Shohreh Issazadeh-Navikas, Bryndis Birnir

110 Citations (Scopus)

Abstract

gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 microM), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha1, alpha4, beta2, beta3, gamma1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 microM GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory.

Original language	English
Journal	Journal of Neuroimmunology
Volume	205
Issue number	1-2
Pages (from-to)	44-50
Number of pages	6
ISSN	0165-5728
DOIs	https://doi.org/10.1016/j.jneuroim.2008.08.017
Publication status	Published - 2008

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10.1016/j.jneuroim.2008.08.017

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title = "GABA, a natural immunomodulator of T lymphocytes",

abstract = "gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 microM), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha1, alpha4, beta2, beta3, gamma1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 microM GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory.",

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T1 - GABA, a natural immunomodulator of T lymphocytes

AU - Bjurstöm, Helen

AU - Wang, Junyang

AU - Ericsson, Ida

AU - Bengtsson, Martin

AU - Liu, Yawei

AU - Kumar-Mendu, Suresh

AU - Issazadeh-Navikas, Shohreh

AU - Birnir, Bryndis

PY - 2008

Y1 - 2008

N2 - gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 microM), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha1, alpha4, beta2, beta3, gamma1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 microM GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory.

AB - gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 microM), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha1, alpha4, beta2, beta3, gamma1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 microM GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory.

U2 - 10.1016/j.jneuroim.2008.08.017

DO - 10.1016/j.jneuroim.2008.08.017

M3 - Journal article

C2 - 18954912

SN - 0165-5728

VL - 205

SP - 44

EP - 50

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

GABA, a natural immunomodulator of T lymphocytes

Abstract

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