Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate

Harish Amin; Jens Juul Holst; Bolette Hartmann; Laurie Wallace; Jim Wright; David L Sigalet

doi:10.1542/peds.2007-1461

Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate

Harish Amin, Jens Juul Holst, Bolette Hartmann, Laurie Wallace, Jim Wright, David L Sigalet

Endocrinology and Metabolism

32 Citations (Scopus)

Abstract

BACKGROUND: The regulation of intestinal growth and development in human neonates is incompletely understood, which hinders the provision of nutrients enterally. The "hindgut" hormones glucagon-like peptides 1 and 2 have been shown to play an important role in the regulation of nutrient assimilation, intestinal growth, and function.

OBJECTIVE: Our goal was to investigate the production of glucagon-like peptides 1 and 2 in premature human infants and examine the effects of prematurity and feeding on hormone release.

PATIENTS AND METHODS: With informed consent, premature infants who were admitted to a tertiary neonatal intensive care nursery (gestational age: 28-32 weeks) were monitored with weekly determinations of postprandial glucagon-like peptide 1 and 2 levels. Comparison studies with groups of normal infants and adults were performed. Hormone levels were obtained by using specific radioimmunoassay for glucagon-like peptide 1 (1-36) and glucagon-like peptide 2 (1-33), modified for small sample volumes; accurate monitoring of enteral intake was performed at all of the sampling time points.

RESULTS: Forty-five infants with a mean gestational age of 29.6 +/- 1.9 weeks were studied; fasting levels of both glucagon-like peptides 1 and 2 were elevated. There was no correlation between gestational age and glucagon-like peptide 2 output. However, both glucagon-like peptide 1 and 2 levels were correlated with the caloric value of feeds.

CONCLUSIONS: The premature human neonate has significantly higher fasting levels of glucagon-like peptides 1 and 2 compared with adults; feeding increases these levels further. These findings suggest that the proglucagon-derived peptides may have a role in normal intestinal development and nutrient handling.

Original language	English
Journal	Pediatrics
Volume	121
Issue number	1
Pages (from-to)	e180-6
ISSN	0031-4005
DOIs	https://doi.org/10.1542/peds.2007-1461
Publication status	Published - Jan 2008

Keywords

Adult
Age Factors
Biological Markers
Case-Control Studies
Child
Cohort Studies
Energy Metabolism
Female
Follow-Up Studies
Gastrointestinal Tract
Gestational Age
Glucagon-Like Peptide 1
Glucagon-Like Peptide 2
Glucagon-Like Peptides
Humans
Infant Food
Infant, Newborn
Infant, Premature
Intensive Care Units, Neonatal
Intestinal Absorption
Male
Pregnancy
Probability
Reference Values
Risk Factors

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10.1542/peds.2007-1461

Cite this

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abstract = "BACKGROUND: The regulation of intestinal growth and development in human neonates is incompletely understood, which hinders the provision of nutrients enterally. The {"}hindgut{"} hormones glucagon-like peptides 1 and 2 have been shown to play an important role in the regulation of nutrient assimilation, intestinal growth, and function.OBJECTIVE: Our goal was to investigate the production of glucagon-like peptides 1 and 2 in premature human infants and examine the effects of prematurity and feeding on hormone release.PATIENTS AND METHODS: With informed consent, premature infants who were admitted to a tertiary neonatal intensive care nursery (gestational age: 28-32 weeks) were monitored with weekly determinations of postprandial glucagon-like peptide 1 and 2 levels. Comparison studies with groups of normal infants and adults were performed. Hormone levels were obtained by using specific radioimmunoassay for glucagon-like peptide 1 (1-36) and glucagon-like peptide 2 (1-33), modified for small sample volumes; accurate monitoring of enteral intake was performed at all of the sampling time points.RESULTS: Forty-five infants with a mean gestational age of 29.6 +/- 1.9 weeks were studied; fasting levels of both glucagon-like peptides 1 and 2 were elevated. There was no correlation between gestational age and glucagon-like peptide 2 output. However, both glucagon-like peptide 1 and 2 levels were correlated with the caloric value of feeds.CONCLUSIONS: The premature human neonate has significantly higher fasting levels of glucagon-like peptides 1 and 2 compared with adults; feeding increases these levels further. These findings suggest that the proglucagon-derived peptides may have a role in normal intestinal development and nutrient handling.",

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author = "Harish Amin and Holst, {Jens Juul} and Bolette Hartmann and Laurie Wallace and Jim Wright and Sigalet, {David L}",

year = "2008",

month = jan,

doi = "10.1542/peds.2007-1461",

language = "English",

volume = "121",

pages = "e180--6",

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T1 - Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate

AU - Amin, Harish

AU - Holst, Jens Juul

AU - Hartmann, Bolette

AU - Wallace, Laurie

AU - Wright, Jim

AU - Sigalet, David L

PY - 2008/1

Y1 - 2008/1

N2 - BACKGROUND: The regulation of intestinal growth and development in human neonates is incompletely understood, which hinders the provision of nutrients enterally. The "hindgut" hormones glucagon-like peptides 1 and 2 have been shown to play an important role in the regulation of nutrient assimilation, intestinal growth, and function.OBJECTIVE: Our goal was to investigate the production of glucagon-like peptides 1 and 2 in premature human infants and examine the effects of prematurity and feeding on hormone release.PATIENTS AND METHODS: With informed consent, premature infants who were admitted to a tertiary neonatal intensive care nursery (gestational age: 28-32 weeks) were monitored with weekly determinations of postprandial glucagon-like peptide 1 and 2 levels. Comparison studies with groups of normal infants and adults were performed. Hormone levels were obtained by using specific radioimmunoassay for glucagon-like peptide 1 (1-36) and glucagon-like peptide 2 (1-33), modified for small sample volumes; accurate monitoring of enteral intake was performed at all of the sampling time points.RESULTS: Forty-five infants with a mean gestational age of 29.6 +/- 1.9 weeks were studied; fasting levels of both glucagon-like peptides 1 and 2 were elevated. There was no correlation between gestational age and glucagon-like peptide 2 output. However, both glucagon-like peptide 1 and 2 levels were correlated with the caloric value of feeds.CONCLUSIONS: The premature human neonate has significantly higher fasting levels of glucagon-like peptides 1 and 2 compared with adults; feeding increases these levels further. These findings suggest that the proglucagon-derived peptides may have a role in normal intestinal development and nutrient handling.

AB - BACKGROUND: The regulation of intestinal growth and development in human neonates is incompletely understood, which hinders the provision of nutrients enterally. The "hindgut" hormones glucagon-like peptides 1 and 2 have been shown to play an important role in the regulation of nutrient assimilation, intestinal growth, and function.OBJECTIVE: Our goal was to investigate the production of glucagon-like peptides 1 and 2 in premature human infants and examine the effects of prematurity and feeding on hormone release.PATIENTS AND METHODS: With informed consent, premature infants who were admitted to a tertiary neonatal intensive care nursery (gestational age: 28-32 weeks) were monitored with weekly determinations of postprandial glucagon-like peptide 1 and 2 levels. Comparison studies with groups of normal infants and adults were performed. Hormone levels were obtained by using specific radioimmunoassay for glucagon-like peptide 1 (1-36) and glucagon-like peptide 2 (1-33), modified for small sample volumes; accurate monitoring of enteral intake was performed at all of the sampling time points.RESULTS: Forty-five infants with a mean gestational age of 29.6 +/- 1.9 weeks were studied; fasting levels of both glucagon-like peptides 1 and 2 were elevated. There was no correlation between gestational age and glucagon-like peptide 2 output. However, both glucagon-like peptide 1 and 2 levels were correlated with the caloric value of feeds.CONCLUSIONS: The premature human neonate has significantly higher fasting levels of glucagon-like peptides 1 and 2 compared with adults; feeding increases these levels further. These findings suggest that the proglucagon-derived peptides may have a role in normal intestinal development and nutrient handling.

KW - Adult

KW - Age Factors

KW - Biological Markers

KW - Case-Control Studies

KW - Child

KW - Cohort Studies

KW - Energy Metabolism

KW - Female

KW - Follow-Up Studies

KW - Gastrointestinal Tract

KW - Gestational Age

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KW - Glucagon-Like Peptide 2

KW - Glucagon-Like Peptides

KW - Humans

KW - Infant Food

KW - Infant, Newborn

KW - Infant, Premature

KW - Intensive Care Units, Neonatal

KW - Intestinal Absorption

KW - Male

KW - Pregnancy

KW - Probability

KW - Reference Values

KW - Risk Factors

U2 - 10.1542/peds.2007-1461

DO - 10.1542/peds.2007-1461

M3 - Journal article

C2 - 18166537

SN - 0031-4005

VL - 121

SP - e180-6

JO - Pediatrics

JF - Pediatrics

IS - 1

ER -

Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate

Abstract

Keywords

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