First case of disseminated cryptococcosis in a Gorilla gorilla

Alexander Mischnik; Julia Stockklausner; Nicole Hohneder; Henrik Elvang Jensen; Stefan Zimmermann; David E. Reuss; Volker Rickerts; Kathrin Tintelnot; Clemens Stockklausner

doi:10.1111/myc.12215

First case of disseminated cryptococcosis in a Gorilla gorilla

Alexander Mischnik, Julia Stockklausner, Nicole Hohneder, Henrik Elvang Jensen, Stefan Zimmermann, David E. Reuss, Volker Rickerts, Kathrin Tintelnot, Clemens Stockklausner

4 Citations (Scopus)

Abstract

Summary: In humans, Cryptococcus mainly infects individuals with HIV infection or other types of immunosuppression. Here, we report the first case of disseminated cryptococcosis in a simian immunodeficiency virus-negative 27-year-old female Gorilla gorilla presenting with lethargy, progressive weight loss and productive cough. The diagnosis was confirmed by positive lung biopsy culture, serum cryptococcal antigen, and cerebral histopathology demonstrating encapsulated yeasts. Molecular characterisation of lung culture isolate yielded Cryptococcus neoformans var. grubii. An immune-deficiency could not be demonstrated.

Original language	English
Journal	Mycoses
Volume	57
Issue number	11
Pages (from-to)	664-671
Number of pages	8
ISSN	0933-7407
DOIs	https://doi.org/10.1111/myc.12215
Publication status	Published - 1 Nov 2014

Keywords

Faculty of Health and Medical Sciences
Cryptococcus
meningoencephalitis
gorilla
mucicarmine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/myc.12215

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title = "First case of disseminated cryptococcosis in a Gorilla gorilla",

abstract = "Summary: In humans, Cryptococcus mainly infects individuals with HIV infection or other types of immunosuppression. Here, we report the first case of disseminated cryptococcosis in a simian immunodeficiency virus-negative 27-year-old female Gorilla gorilla presenting with lethargy, progressive weight loss and productive cough. The diagnosis was confirmed by positive lung biopsy culture, serum cryptococcal antigen, and cerebral histopathology demonstrating encapsulated yeasts. Molecular characterisation of lung culture isolate yielded Cryptococcus neoformans var. grubii. An immune-deficiency could not be demonstrated.",

keywords = "Faculty of Health and Medical Sciences, Cryptococcus, meningoencephalitis, gorilla, mucicarmine",

author = "Alexander Mischnik and Julia Stockklausner and Nicole Hohneder and Jensen, {Henrik Elvang} and Stefan Zimmermann and Reuss, {David E.} and Volker Rickerts and Kathrin Tintelnot and Clemens Stockklausner",

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T1 - First case of disseminated cryptococcosis in a Gorilla gorilla

AU - Mischnik, Alexander

AU - Stockklausner, Julia

AU - Hohneder, Nicole

AU - Jensen, Henrik Elvang

AU - Zimmermann, Stefan

AU - Reuss, David E.

AU - Rickerts, Volker

AU - Tintelnot, Kathrin

AU - Stockklausner, Clemens

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Summary: In humans, Cryptococcus mainly infects individuals with HIV infection or other types of immunosuppression. Here, we report the first case of disseminated cryptococcosis in a simian immunodeficiency virus-negative 27-year-old female Gorilla gorilla presenting with lethargy, progressive weight loss and productive cough. The diagnosis was confirmed by positive lung biopsy culture, serum cryptococcal antigen, and cerebral histopathology demonstrating encapsulated yeasts. Molecular characterisation of lung culture isolate yielded Cryptococcus neoformans var. grubii. An immune-deficiency could not be demonstrated.

AB - Summary: In humans, Cryptococcus mainly infects individuals with HIV infection or other types of immunosuppression. Here, we report the first case of disseminated cryptococcosis in a simian immunodeficiency virus-negative 27-year-old female Gorilla gorilla presenting with lethargy, progressive weight loss and productive cough. The diagnosis was confirmed by positive lung biopsy culture, serum cryptococcal antigen, and cerebral histopathology demonstrating encapsulated yeasts. Molecular characterisation of lung culture isolate yielded Cryptococcus neoformans var. grubii. An immune-deficiency could not be demonstrated.

KW - Faculty of Health and Medical Sciences

KW - Cryptococcus

KW - meningoencephalitis

KW - gorilla

KW - mucicarmine

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DO - 10.1111/myc.12215

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VL - 57

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EP - 671

JO - Mycoses

JF - Mycoses

IS - 11

ER -

First case of disseminated cryptococcosis in a Gorilla gorilla

Abstract

Keywords

UN SDGs

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