Filaggringenmutationer er hypige og öger risikoen for hudsygdom

Martin Willy Meyer; Jacob Pontoppidan Thyssen

Filaggringenmutationer er hypige og öger risikoen for hudsygdom

Translated title of the contribution: [Filaggrin gene mutations are frequent and increase the risk of skin disease]

Martin Willy Meyer, Jacob Pontoppidan Thyssen

Teaching

Abstract

Filaggrin proteins are important for the epidermal differentiation and skin barrier function. About 10% of Europeans carry loss-of-function mutations within the filaggrin gene complex. Mutations are strongly associated with ichthyosis vulgaris and atopic dermatitis as well as dry and fissured skin. No overall association with psoriasis vulgaris has been identified. The filaggrin gene discovery has been a major breakthrough for dermatology in terms of diagnostics and prognostics, but it has not yet been translated into therapeutic advances.

Translated title of the contribution	[Filaggrin gene mutations are frequent and increase the risk of skin disease]
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	173
Issue number	43
Pages (from-to)	2705-8
Number of pages	4
ISSN	0041-5782
Publication status	Published - Oct 2011

Cite this

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title = "Filaggringenmutationer er hypige og {\"o}ger risikoen for hudsygdom",

abstract = "Filaggrin proteins are important for the epidermal differentiation and skin barrier function. About 10% of Europeans carry loss-of-function mutations within the filaggrin gene complex. Mutations are strongly associated with ichthyosis vulgaris and atopic dermatitis as well as dry and fissured skin. No overall association with psoriasis vulgaris has been identified. The filaggrin gene discovery has been a major breakthrough for dermatology in terms of diagnostics and prognostics, but it has not yet been translated into therapeutic advances.",

author = "Meyer, {Martin Willy} and Thyssen, {Jacob Pontoppidan}",

year = "2011",

month = oct,

language = "Dansk",

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T1 - Filaggringenmutationer er hypige og öger risikoen for hudsygdom

AU - Meyer, Martin Willy

AU - Thyssen, Jacob Pontoppidan

PY - 2011/10

Y1 - 2011/10

N2 - Filaggrin proteins are important for the epidermal differentiation and skin barrier function. About 10% of Europeans carry loss-of-function mutations within the filaggrin gene complex. Mutations are strongly associated with ichthyosis vulgaris and atopic dermatitis as well as dry and fissured skin. No overall association with psoriasis vulgaris has been identified. The filaggrin gene discovery has been a major breakthrough for dermatology in terms of diagnostics and prognostics, but it has not yet been translated into therapeutic advances.

AB - Filaggrin proteins are important for the epidermal differentiation and skin barrier function. About 10% of Europeans carry loss-of-function mutations within the filaggrin gene complex. Mutations are strongly associated with ichthyosis vulgaris and atopic dermatitis as well as dry and fissured skin. No overall association with psoriasis vulgaris has been identified. The filaggrin gene discovery has been a major breakthrough for dermatology in terms of diagnostics and prognostics, but it has not yet been translated into therapeutic advances.

M3 - Tidsskriftartikel

SN - 0041-5782

VL - 173

SP - 2705

EP - 2708

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 43

ER -

Filaggringenmutationer er hypige og öger risikoen for hudsygdom

Abstract

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