Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine

Gunnar Toft; Virissa Lenters; Roel Vermeulen; Dick Heederik; Cathrine Thomsen; Georg Becher; Aleksander Giwercman; Davide Bizzaro; Gian Carlo Manicardi; Marcello Spanò; Lars Rylander; Henning S Pedersen; Paweł Struciński; Valentyna Zviezdai; Jens Peter Bonde

doi:10.1016/j.reprotox.2013.10.002

Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine

Gunnar Toft, Virissa Lenters, Roel Vermeulen, Dick Heederik, Cathrine Thomsen, Georg Becher, Aleksander Giwercman, Davide Bizzaro, Gian Carlo Manicardi, Marcello Spanò, Lars Rylander, Henning S Pedersen, Paweł Struciński, Valentyna Zviezdai, Jens Peter Bonde

11 Citations (Scopus)

Abstract

Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.

Original language	English
Journal	Reproductive Toxicology
Volume	43
Pages (from-to)	1-7
Number of pages	7
ISSN	0890-6238
DOIs	https://doi.org/10.1016/j.reprotox.2013.10.002
Publication status	Published - Jan 2014

Keywords

Adult
DNA Damage
Environmental Monitoring
Environmental Pollutants
Estradiol
Flame Retardants
Follicle Stimulating Hormone
Greenland
Halogenated Diphenyl Ethers
Humans
In Situ Nick-End Labeling
Luteinizing Hormone
Male
Poland
Polybrominated Biphenyls
Sperm Count
Sperm Motility
Testosterone
Ukraine
Young Adult

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Toft, G., Lenters, V., Vermeulen, R., Heederik, D., Thomsen, C., Becher, G., Giwercman, A., Bizzaro, D., Manicardi, G. C., Spanò, M., Rylander, L., Pedersen, H. S., Struciński, P., Zviezdai, V., & Bonde, J. P. (2014). Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine. Reproductive Toxicology, 43, 1-7. https://doi.org/10.1016/j.reprotox.2013.10.002

Toft, G, Lenters, V, Vermeulen, R, Heederik, D, Thomsen, C, Becher, G, Giwercman, A, Bizzaro, D, Manicardi, GC, Spanò, M, Rylander, L, Pedersen, HS, Struciński, P, Zviezdai, V & Bonde, JP 2014, 'Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine', Reproductive Toxicology, vol. 43, pp. 1-7. https://doi.org/10.1016/j.reprotox.2013.10.002

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abstract = "Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.",

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author = "Gunnar Toft and Virissa Lenters and Roel Vermeulen and Dick Heederik and Cathrine Thomsen and Georg Becher and Aleksander Giwercman and Davide Bizzaro and Manicardi, {Gian Carlo} and Marcello Span{\`o} and Lars Rylander and Pedersen, {Henning S} and Pawe{\l} Struci{\'n}ski and Valentyna Zviezdai and Bonde, {Jens Peter}",

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AU - Toft, Gunnar

AU - Lenters, Virissa

AU - Vermeulen, Roel

AU - Heederik, Dick

AU - Thomsen, Cathrine

AU - Becher, Georg

AU - Giwercman, Aleksander

AU - Bizzaro, Davide

AU - Manicardi, Gian Carlo

AU - Spanò, Marcello

AU - Rylander, Lars

AU - Pedersen, Henning S

AU - Struciński, Paweł

AU - Zviezdai, Valentyna

AU - Bonde, Jens Peter

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AB - Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.

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KW - DNA Damage

KW - Environmental Monitoring

KW - Environmental Pollutants

KW - Estradiol

KW - Flame Retardants

KW - Follicle Stimulating Hormone

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KW - Halogenated Diphenyl Ethers

KW - Humans

KW - In Situ Nick-End Labeling

KW - Luteinizing Hormone

KW - Male

KW - Poland

KW - Polybrominated Biphenyls

KW - Sperm Count

KW - Sperm Motility

KW - Testosterone

KW - Ukraine

KW - Young Adult

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DO - 10.1016/j.reprotox.2013.10.002

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C2 - 24513925

SN - 0890-6238

VL - 43

SP - 1

EP - 7

JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -

Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine

Abstract

Keywords

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