European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I

Susanne Krege; Jörg Beyer; Rainer Souchon; Peter Albers; Walter Albrecht; Ferran Algaba; Michael Bamberg; István Bodrogi; Carsten Bokemeyer; Eva Cavallin-Ståhl; Johannes Classen; Christoph Clemm; Gabriella Cohn-Cedermark; Stéphane Culine; Gedske Daugaard; Pieter H M De Mulder; Maria De Santis; Maike de Wit; Ronald de Wit; Hans Günter Derigs; Klaus-Peter Dieckmann; Annette Dieing; Jean-Pierre Droz; Martin Fenner; Karim Fizazi; Aude Flechon; Sophie D Fosså; Xavier Garcia del Muro; Thomas Gauler; Lajos Geczi; Arthur Gerl; Jose Ramon Germa-Lluch; Silke Gillessen; Jörg T Hartmann; Michael Hartmann; Axel Heidenreich; Wolfgang Hoeltl; Alan Horwich; Robert Huddart; Michael Jewett; Johnathan Joffe; William G Jones; László Kisbenedek; Olbjørn Klepp; Sabine Kliesch; Kai Uwe Koehrmann; Christian Kollmannsberger; Markus Kuczyk; Pilar Laguna; Oscar Leiva Galvis; Volker Loy; Malcolm D Mason; Graham M Mead; Rolf Mueller; Craig Nichols; Nicola Nicolai; Tim Oliver; Dalibor Ondrus; Gosse O N Oosterhof; Luis Paz Ares; Giorgio Pizzocaro; Jörg Pont; Tobias Pottek; Tom Powles; Oliver Rick; Giovanni Rosti; Roberto Salvioni; Jutta Scheiderbauer; Hans-Ulrich Schmelz; Heinz Schmidberger; Hans-Joachim Schmoll; Mark Schrader; Felix Sedlmayer; Niels E Skakkebaek; Aslam Sohaib; Sergei Tjulandin; Padraig Warde; Stefan Weinknecht; Lothar Weissbach; Christian Wittekind; Eva Winter; Lori Wood; Hans von der Maase

doi:10.1016/j.eururo.2007.12.024

European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I

Susanne Krege, Jörg Beyer, Rainer Souchon, Peter Albers, Walter Albrecht, Ferran Algaba, Michael Bamberg, István Bodrogi, Carsten Bokemeyer, Eva Cavallin-Ståhl, Johannes Classen, Christoph Clemm, Gabriella Cohn-Cedermark, Stéphane Culine, Gedske Daugaard, Pieter H M De Mulder, Maria De Santis, Maike de Wit, Ronald de Wit, Hans Günter DerigsKlaus-Peter Dieckmann, Annette Dieing, Jean-Pierre Droz, Martin Fenner, Karim Fizazi, Aude Flechon, Sophie D Fosså, Xavier Garcia del Muro, Thomas Gauler, Lajos Geczi, Arthur Gerl, Jose Ramon Germa-Lluch, Silke Gillessen, Jörg T Hartmann, Michael Hartmann, Axel Heidenreich, Wolfgang Hoeltl, Alan Horwich, Robert Huddart, Michael Jewett, Johnathan Joffe, William G Jones, László Kisbenedek, Olbjørn Klepp, Sabine Kliesch, Kai Uwe Koehrmann, Christian Kollmannsberger, Markus Kuczyk, Pilar Laguna, Oscar Leiva Galvis, Volker Loy, Malcolm D Mason, Graham M Mead, Rolf Mueller, Craig Nichols, Nicola Nicolai, Tim Oliver, Dalibor Ondrus, Gosse O N Oosterhof, Luis Paz Ares, Giorgio Pizzocaro, Jörg Pont, Tobias Pottek, Tom Powles, Oliver Rick, Giovanni Rosti, Roberto Salvioni, Jutta Scheiderbauer, Hans-Ulrich Schmelz, Heinz Schmidberger, Hans-Joachim Schmoll, Mark Schrader, Felix Sedlmayer, Niels E Skakkebaek, Aslam Sohaib, Sergei Tjulandin, Padraig Warde, Stefan Weinknecht, Lothar Weissbach, Christian Wittekind, Eva Winter, Lori Wood, Hans von der Maase

Department of Clinical Medicine

384 Citations (Scopus)

Abstract

OBJECTIVES: The first consensus report presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in the year 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, Amsterdam, The Netherlands. METHODS: Medical oncologists, urological surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference, and incorporated the new data into updated and revised guidelines. As for the first meeting, the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. RESULTS: The first part of the consensus paper describes the clinical presentation of the primary tumor, its treatment, the importance and treatment of testicular intraepithelial neoplasia (TIN), histological classification, staging and prognostic factors, and treatment of stage I seminoma and non-seminoma. CONCLUSIONS: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early- and advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged
Udgivelsesdato: 2008/3

Original language	English
Journal	European Urology
Volume	53
Issue number	3
Pages (from-to)	478-496
Number of pages	18
ISSN	0302-2838
DOIs	https://doi.org/10.1016/j.eururo.2007.12.024
Publication status	Published - 2007

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Krege, S., Beyer, J., Souchon, R., Albers, P., Albrecht, W., Algaba, F., Bamberg, M., Bodrogi, I., Bokemeyer, C., Cavallin-Ståhl, E., Classen, J., Clemm, C., Cohn-Cedermark, G., Culine, S., Daugaard, G., De Mulder, P. H. M., De Santis, M., de Wit, M., de Wit, R., ... von der Maase, H. (2007). European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I. European Urology, 53(3), 478-496. https://doi.org/10.1016/j.eururo.2007.12.024

European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I. / Krege, Susanne; Beyer, Jörg; Souchon, Rainer et al.

In: European Urology, Vol. 53, No. 3, 2007, p. 478-496.

Research output: Contribution to journal › Journal article › Research › peer-review

Krege, S, Beyer, J, Souchon, R, Albers, P, Albrecht, W, Algaba, F, Bamberg, M, Bodrogi, I, Bokemeyer, C, Cavallin-Ståhl, E, Classen, J, Clemm, C, Cohn-Cedermark, G, Culine, S, Daugaard, G, De Mulder, PHM, De Santis, M, de Wit, M, de Wit, R, Derigs, HG, Dieckmann, K-P, Dieing, A, Droz, J-P, Fenner, M, Fizazi, K, Flechon, A, Fosså, SD, del Muro, XG, Gauler, T, Geczi, L, Gerl, A, Germa-Lluch, JR, Gillessen, S, Hartmann, JT, Hartmann, M, Heidenreich, A, Hoeltl, W, Horwich, A, Huddart, R, Jewett, M, Joffe, J, Jones, WG, Kisbenedek, L, Klepp, O, Kliesch, S, Koehrmann, KU, Kollmannsberger, C, Kuczyk, M, Laguna, P, Galvis, OL, Loy, V, Mason, MD, Mead, GM, Mueller, R, Nichols, C, Nicolai, N, Oliver, T, Ondrus, D, Oosterhof, GON, Ares, LP, Pizzocaro, G, Pont, J, Pottek, T, Powles, T, Rick, O, Rosti, G, Salvioni, R, Scheiderbauer, J, Schmelz, H-U, Schmidberger, H, Schmoll, H-J, Schrader, M, Sedlmayer, F, Skakkebaek, NE, Sohaib, A, Tjulandin, S, Warde, P, Weinknecht, S, Weissbach, L, Wittekind, C, Winter, E, Wood, L & von der Maase, H 2007, 'European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I', European Urology, vol. 53, no. 3, pp. 478-496. https://doi.org/10.1016/j.eururo.2007.12.024

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title = "European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I",

abstract = "OBJECTIVES: The first consensus report presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in the year 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, Amsterdam, The Netherlands. METHODS: Medical oncologists, urological surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference, and incorporated the new data into updated and revised guidelines. As for the first meeting, the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. RESULTS: The first part of the consensus paper describes the clinical presentation of the primary tumor, its treatment, the importance and treatment of testicular intraepithelial neoplasia (TIN), histological classification, staging and prognostic factors, and treatment of stage I seminoma and non-seminoma. CONCLUSIONS: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early- and advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged Udgivelsesdato: 2008/3",

author = "Susanne Krege and J{\"o}rg Beyer and Rainer Souchon and Peter Albers and Walter Albrecht and Ferran Algaba and Michael Bamberg and Istv{\'a}n Bodrogi and Carsten Bokemeyer and Eva Cavallin-St{\aa}hl and Johannes Classen and Christoph Clemm and Gabriella Cohn-Cedermark and St{\'e}phane Culine and Gedske Daugaard and {De Mulder}, {Pieter H M} and {De Santis}, Maria and {de Wit}, Maike and {de Wit}, Ronald and Derigs, {Hans G{\"u}nter} and Klaus-Peter Dieckmann and Annette Dieing and Jean-Pierre Droz and Martin Fenner and Karim Fizazi and Aude Flechon and Foss{\aa}, {Sophie D} and {del Muro}, {Xavier Garcia} and Thomas Gauler and Lajos Geczi and Arthur Gerl and Germa-Lluch, {Jose Ramon} and Silke Gillessen and Hartmann, {J{\"o}rg T} and Michael Hartmann and Axel Heidenreich and Wolfgang Hoeltl and Alan Horwich and Robert Huddart and Michael Jewett and Johnathan Joffe and Jones, {William G} and L{\'a}szl{\'o} Kisbenedek and Olbj{\o}rn Klepp and Sabine Kliesch and Koehrmann, {Kai Uwe} and Christian Kollmannsberger and Markus Kuczyk and Pilar Laguna and Galvis, {Oscar Leiva} and Volker Loy and Mason, {Malcolm D} and Mead, {Graham M} and Rolf Mueller and Craig Nichols and Nicola Nicolai and Tim Oliver and Dalibor Ondrus and Oosterhof, {Gosse O N} and Ares, {Luis Paz} and Giorgio Pizzocaro and J{\"o}rg Pont and Tobias Pottek and Tom Powles and Oliver Rick and Giovanni Rosti and Roberto Salvioni and Jutta Scheiderbauer and Hans-Ulrich Schmelz and Heinz Schmidberger and Hans-Joachim Schmoll and Mark Schrader and Felix Sedlmayer and Skakkebaek, {Niels E} and Aslam Sohaib and Sergei Tjulandin and Padraig Warde and Stefan Weinknecht and Lothar Weissbach and Christian Wittekind and Eva Winter and Lori Wood and {von der Maase}, Hans",

note = "Keywords: Biopsy; Combined Modality Therapy; Consensus; Consensus Development Conferences as Topic; Europe; Humans; Male; Neoplasm Staging; Neoplasms, Germ Cell and Embryonal; Practice Guidelines as Topic; Prognosis; Societies, Medical; Testicular Neoplasms",

year = "2007",

doi = "10.1016/j.eururo.2007.12.024",

language = "English",

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pages = "478--496",

journal = "European Urology",

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TY - JOUR

T1 - European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I

AU - Krege, Susanne

AU - Beyer, Jörg

AU - Souchon, Rainer

AU - Albers, Peter

AU - Albrecht, Walter

AU - Algaba, Ferran

AU - Bamberg, Michael

AU - Bodrogi, István

AU - Bokemeyer, Carsten

AU - Cavallin-Ståhl, Eva

AU - Classen, Johannes

AU - Clemm, Christoph

AU - Cohn-Cedermark, Gabriella

AU - Culine, Stéphane

AU - Daugaard, Gedske

AU - De Mulder, Pieter H M

AU - De Santis, Maria

AU - de Wit, Maike

AU - de Wit, Ronald

AU - Derigs, Hans Günter

AU - Dieckmann, Klaus-Peter

AU - Dieing, Annette

AU - Droz, Jean-Pierre

AU - Fenner, Martin

AU - Fizazi, Karim

AU - Flechon, Aude

AU - Fosså, Sophie D

AU - del Muro, Xavier Garcia

AU - Gauler, Thomas

AU - Geczi, Lajos

AU - Gerl, Arthur

AU - Germa-Lluch, Jose Ramon

AU - Gillessen, Silke

AU - Hartmann, Jörg T

AU - Hartmann, Michael

AU - Heidenreich, Axel

AU - Hoeltl, Wolfgang

AU - Horwich, Alan

AU - Huddart, Robert

AU - Jewett, Michael

AU - Joffe, Johnathan

AU - Jones, William G

AU - Kisbenedek, László

AU - Klepp, Olbjørn

AU - Kliesch, Sabine

AU - Koehrmann, Kai Uwe

AU - Kollmannsberger, Christian

AU - Kuczyk, Markus

AU - Laguna, Pilar

AU - Galvis, Oscar Leiva

AU - Loy, Volker

AU - Mason, Malcolm D

AU - Mead, Graham M

AU - Mueller, Rolf

AU - Nichols, Craig

AU - Nicolai, Nicola

AU - Oliver, Tim

AU - Ondrus, Dalibor

AU - Oosterhof, Gosse O N

AU - Ares, Luis Paz

AU - Pizzocaro, Giorgio

AU - Pont, Jörg

AU - Pottek, Tobias

AU - Powles, Tom

AU - Rick, Oliver

AU - Rosti, Giovanni

AU - Salvioni, Roberto

AU - Scheiderbauer, Jutta

AU - Schmelz, Hans-Ulrich

AU - Schmidberger, Heinz

AU - Schmoll, Hans-Joachim

AU - Schrader, Mark

AU - Sedlmayer, Felix

AU - Skakkebaek, Niels E

AU - Sohaib, Aslam

AU - Tjulandin, Sergei

AU - Warde, Padraig

AU - Weinknecht, Stefan

AU - Weissbach, Lothar

AU - Wittekind, Christian

AU - Winter, Eva

AU - Wood, Lori

AU - von der Maase, Hans

N1 - Keywords: Biopsy; Combined Modality Therapy; Consensus; Consensus Development Conferences as Topic; Europe; Humans; Male; Neoplasm Staging; Neoplasms, Germ Cell and Embryonal; Practice Guidelines as Topic; Prognosis; Societies, Medical; Testicular Neoplasms

PY - 2007

Y1 - 2007

N2 - OBJECTIVES: The first consensus report presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in the year 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, Amsterdam, The Netherlands. METHODS: Medical oncologists, urological surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference, and incorporated the new data into updated and revised guidelines. As for the first meeting, the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. RESULTS: The first part of the consensus paper describes the clinical presentation of the primary tumor, its treatment, the importance and treatment of testicular intraepithelial neoplasia (TIN), histological classification, staging and prognostic factors, and treatment of stage I seminoma and non-seminoma. CONCLUSIONS: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early- and advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged Udgivelsesdato: 2008/3

AB - OBJECTIVES: The first consensus report presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in the year 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, Amsterdam, The Netherlands. METHODS: Medical oncologists, urological surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference, and incorporated the new data into updated and revised guidelines. As for the first meeting, the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. RESULTS: The first part of the consensus paper describes the clinical presentation of the primary tumor, its treatment, the importance and treatment of testicular intraepithelial neoplasia (TIN), histological classification, staging and prognostic factors, and treatment of stage I seminoma and non-seminoma. CONCLUSIONS: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early- and advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged Udgivelsesdato: 2008/3

U2 - 10.1016/j.eururo.2007.12.024

DO - 10.1016/j.eururo.2007.12.024

M3 - Journal article

C2 - 18191324

SN - 0302-2838

VL - 53

SP - 478

EP - 496

JO - European Urology

JF - European Urology

IS - 3

ER -