Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.

Yves Benninger; Tina Thurnherr; Jorge A Pereira; Sven Krause; Xunwei Wu; Anna Chrostek-Grashoff; Dominik Herzog; Klaus-Armin Nave; Robin J M Franklin; Dies Meijer; Cord Brakebusch; Ueli Suter; João B Relvas

doi:10.1083/jcb.200610108

Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.

Yves Benninger, Tina Thurnherr, Jorge A Pereira, Sven Krause, Xunwei Wu, Anna Chrostek-Grashoff, Dominik Herzog, Klaus-Armin Nave, Robin J M Franklin, Dies Meijer, Cord Brakebusch, Ueli Suter, João B Relvas

Department of Biomedical Sciences

141 Citations (Scopus)

Abstract

During peripheral nervous system (PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic developmental program accordingly. The pathways and mechanisms involved in this process are only partially understood. We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells. Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles.

Original language	English
Journal	Journal of Cell Biology
Volume	177
Issue number	6
Pages (from-to)	1051-61
Number of pages	10
ISSN	0021-9525
DOIs	https://doi.org/10.1083/jcb.200610108
Publication status	Published - 2007

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Benninger, Y., Thurnherr, T., Pereira, J. A., Krause, S., Wu, X., Chrostek-Grashoff, A., Herzog, D., Nave, K-A., Franklin, R. J. M., Meijer, D., Brakebusch, C., Suter, U., & Relvas, J. B. (2007). Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development. Journal of Cell Biology, 177(6), 1051-61. https://doi.org/10.1083/jcb.200610108

Benninger, Y, Thurnherr, T, Pereira, JA, Krause, S, Wu, X, Chrostek-Grashoff, A, Herzog, D, Nave, K-A, Franklin, RJM, Meijer, D, Brakebusch, C, Suter, U & Relvas, JB 2007, 'Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.', Journal of Cell Biology, vol. 177, no. 6, pp. 1051-61. https://doi.org/10.1083/jcb.200610108

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title = "Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.",

abstract = "During peripheral nervous system (PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic developmental program accordingly. The pathways and mechanisms involved in this process are only partially understood. We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells. Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles.",

author = "Yves Benninger and Tina Thurnherr and Pereira, {Jorge A} and Sven Krause and Xunwei Wu and Anna Chrostek-Grashoff and Dominik Herzog and Klaus-Armin Nave and Franklin, {Robin J M} and Dies Meijer and Cord Brakebusch and Ueli Suter and Relvas, {Jo{\~a}o B}",

note = "Keywords: Animals; Axons; Cell Surface Extensions; Mice; Mice, Knockout; Neuropeptides; Peripheral Nervous System; Schwann Cells; cdc42 GTP-Binding Protein; rac GTP-Binding Proteins",

year = "2007",

doi = "10.1083/jcb.200610108",

language = "English",

volume = "177",

pages = "1051--61",

journal = "Journal of Cell Biology",

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T1 - Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.

AU - Benninger, Yves

AU - Thurnherr, Tina

AU - Pereira, Jorge A

AU - Krause, Sven

AU - Wu, Xunwei

AU - Chrostek-Grashoff, Anna

AU - Herzog, Dominik

AU - Nave, Klaus-Armin

AU - Franklin, Robin J M

AU - Meijer, Dies

AU - Brakebusch, Cord

AU - Suter, Ueli

AU - Relvas, João B

N1 - Keywords: Animals; Axons; Cell Surface Extensions; Mice; Mice, Knockout; Neuropeptides; Peripheral Nervous System; Schwann Cells; cdc42 GTP-Binding Protein; rac GTP-Binding Proteins

PY - 2007

Y1 - 2007

N2 - During peripheral nervous system (PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic developmental program accordingly. The pathways and mechanisms involved in this process are only partially understood. We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells. Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles.

AB - During peripheral nervous system (PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic developmental program accordingly. The pathways and mechanisms involved in this process are only partially understood. We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells. Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles.

U2 - 10.1083/jcb.200610108

DO - 10.1083/jcb.200610108

M3 - Journal article

C2 - 17576798

SN - 0021-9525

VL - 177

SP - 1051

EP - 1061

JO - Journal of Cell Biology

JF - Journal of Cell Biology

IS - 6

ER -

Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.

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