Epidemiology of Non-hereditary Angioedema

Flemming Madsen; Jørn Attermann; Allan Linneberg

doi:http://dx.doi.org/10.2340/00015555-1389

Epidemiology of Non-hereditary Angioedema

Flemming Madsen, Jørn Attermann, Allan Linneberg

23 Citations (Scopus)

Abstract

The prevalence of non-hereditary angioedema was investigated in a general population sample (n¿=¿7,931) and in a sample of Danish patients (n¿=¿7,433) tested for deficiency of functional complement C1 esterase inhibitor protein (functional C1 INH). The general population sample (44% response rate) reported a lifetime prevalence of 7.4% for angioedema. In both groups symptoms were most frequent in the lips, head, neck, eyes and tongue. In the C1 INH test normal group angioedema was still active at the time of the study in 53% of the patients, and 36% reported symptoms in the throat, 23% in the abdominal area, 17% had diarrhoea, 11% had vomiting and 6% fainted during attacks. Non-hereditary angioedema has high lifetime prevalence and becomes chronic in approximately 50% of affected patients. Symptoms in the larynx and throat, as well as non-specific symptoms, such as dizziness and abdominal pain, were more frequent than previously reported.

Original language	English
Journal	Acta Dermato Venereologica
Pages (from-to)	475-9
ISSN	0001-5555
DOIs	https://doi.org/10.2340/00015555-1389
Publication status	Published - 2012

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title = "Epidemiology of Non-hereditary Angioedema",

abstract = "The prevalence of non-hereditary angioedema was investigated in a general population sample (n¿=¿7,931) and in a sample of Danish patients (n¿=¿7,433) tested for deficiency of functional complement C1 esterase inhibitor protein (functional C1 INH). The general population sample (44% response rate) reported a lifetime prevalence of 7.4% for angioedema. In both groups symptoms were most frequent in the lips, head, neck, eyes and tongue. In the C1 INH test normal group angioedema was still active at the time of the study in 53% of the patients, and 36% reported symptoms in the throat, 23% in the abdominal area, 17% had diarrhoea, 11% had vomiting and 6% fainted during attacks. Non-hereditary angioedema has high lifetime prevalence and becomes chronic in approximately 50% of affected patients. Symptoms in the larynx and throat, as well as non-specific symptoms, such as dizziness and abdominal pain, were more frequent than previously reported.",

author = "Flemming Madsen and J{\o}rn Attermann and Allan Linneberg",

year = "2012",

doi = "http://dx.doi.org/10.2340/00015555-1389",

language = "English",

pages = "475--9",

journal = "Acta Dermato-Venereologica",

issn = "0001-5555",

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TY - JOUR

T1 - Epidemiology of Non-hereditary Angioedema

AU - Madsen, Flemming

AU - Attermann, Jørn

AU - Linneberg, Allan

PY - 2012

Y1 - 2012

N2 - The prevalence of non-hereditary angioedema was investigated in a general population sample (n¿=¿7,931) and in a sample of Danish patients (n¿=¿7,433) tested for deficiency of functional complement C1 esterase inhibitor protein (functional C1 INH). The general population sample (44% response rate) reported a lifetime prevalence of 7.4% for angioedema. In both groups symptoms were most frequent in the lips, head, neck, eyes and tongue. In the C1 INH test normal group angioedema was still active at the time of the study in 53% of the patients, and 36% reported symptoms in the throat, 23% in the abdominal area, 17% had diarrhoea, 11% had vomiting and 6% fainted during attacks. Non-hereditary angioedema has high lifetime prevalence and becomes chronic in approximately 50% of affected patients. Symptoms in the larynx and throat, as well as non-specific symptoms, such as dizziness and abdominal pain, were more frequent than previously reported.

AB - The prevalence of non-hereditary angioedema was investigated in a general population sample (n¿=¿7,931) and in a sample of Danish patients (n¿=¿7,433) tested for deficiency of functional complement C1 esterase inhibitor protein (functional C1 INH). The general population sample (44% response rate) reported a lifetime prevalence of 7.4% for angioedema. In both groups symptoms were most frequent in the lips, head, neck, eyes and tongue. In the C1 INH test normal group angioedema was still active at the time of the study in 53% of the patients, and 36% reported symptoms in the throat, 23% in the abdominal area, 17% had diarrhoea, 11% had vomiting and 6% fainted during attacks. Non-hereditary angioedema has high lifetime prevalence and becomes chronic in approximately 50% of affected patients. Symptoms in the larynx and throat, as well as non-specific symptoms, such as dizziness and abdominal pain, were more frequent than previously reported.

U2 - http://dx.doi.org/10.2340/00015555-1389

DO - http://dx.doi.org/10.2340/00015555-1389

M3 - Journal article

SN - 0001-5555

SP - 475

EP - 479

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

ER -

Epidemiology of Non-hereditary Angioedema

Abstract

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