Abstract
Aims: To compare the responses of GIP, GLP-1, ghrelin and IGFBP-1 between meals with different fat and energy content in adolescents with type 1 diabetes (T1DM) and to relate them to gastric emptying and glycaemia. Methods: On different days and in a random order, 7 adolescents with T1DM ingested a high- and low-fat meal (fat content: 38 and 2 g, energy content: 640 and 320 kcal, respectively). At normoglycaemia, the same prandial insulin dose was given at both meals and to all subjects. Postprandial blood samples were taken repeatedly over 4 hours. Gastric emptying was estimated by the paracetamol absorption method. Results: The area under the curve (AUC) for GIP(0-240 min) and for GLP-1(0-120 min) was larger, but smaller for relative ghrelin(0-240 min), after the high-fat meal (p = 0.002, 0.030 and 0.043, respectively). IGFBP-1 decreased significantly, but not differently, after the meals. Larger GLP-1 secretion correlated with slower gastric emptying (p = 0.029) and higher fasting ghrelin levels correlated with lower postprandial glycaemia (p = 0.007). Conclusion: In adolescents with T1DM, the postprandial responses of GIP, GLP-1 and ghrelin, but not that of IGFBP-1, depend more on meal size than on insulin.
| Original language | English |
|---|---|
| Journal | Hormone research in pædiatrics |
| Volume | 73 |
| Issue number | 5 |
| Pages (from-to) | 355-362 |
| Number of pages | 8 |
| DOIs | |
| Publication status | Published - Apr 2010 |
Keywords
- Adolescent
- Area Under Curve
- Blood Glucose
- Diabetes Mellitus, Type 1
- Dietary Fats
- Energy Intake
- Female
- Gastric Emptying
- Gastric Inhibitory Polypeptide
- Ghrelin
- Glucagon-Like Peptide 1
- Humans
- Insulin
- Insulin-Like Growth Factor Binding Protein 1
- Male
- Pilot Projects
- Postprandial Period
