Effect of beta-blockade and ACE inhibition on B-type natriuretic peptides in stable patients with systolic heart failure

J. Rosenberg; F. Gustafsson; W.J. Remme; G.A.J. Riegger; P.R. Hildebrandt

Effect of beta-blockade and ACE inhibition on B-type natriuretic peptides in stable patients with systolic heart failure

J. Rosenberg, F. Gustafsson, W.J. Remme, G.A.J. Riegger, P.R. Hildebrandt

32 Citations (Scopus)

Abstract

Introduction The long-term effect of beta-blockade on the plasma levels of natriuretic peptides BNP and its N-terminal counterpart, NT-proBNP, as risk markers in heart failure (HF) is obscure. Methods Stable systolic HF patients from the CARMEN study were divided in groups matching their randomised treatment allocation: Carvedilol, enalapril or carvedilol+enalapril. Changes in BNP and NT-proBNP from baseline to 6 months maintenance visit were evaluated in each treatment arm. Furthermore, the prognostic value of BNP and NT-proBNP during monotherapy with carvedilol was assessed with univariate Cox proportional hazards models using a combined endpoint of all cause mortality and cardiovascular hospitalisation. Results NT-proBNP and BNP were significantly reduced after six months treatment with enalapril (NT-proBNP 1,303 to 857 pg/ml (P<0.001), BNP 119 to 85 pg/ml (P<0.001)) or carvedilol+enalapril (NT-proBNP 1,223 to 953 pg/ml (P=0.003), BNP 117 to 93 pg/ml (P=0.01)). In contrast, no change was observed in the carvedilol group (NT-proBNP 907 to 1,082 pg/ml (P=0.06), BNP 114 to 130 pg/ml (P=0.15). The prognostic value of NT-proBNP and BNP was maintained in the carvedilol group (NT-proBNP HR 1.018 95% CI (1.005-1.032), BNP 1.171 (1.088-1.260)). Conclusion Treatment of HF patients with carvedilol alone does not reduce levels of natriuretic peptides, but treatment with enalapril does. Both BNP and NT-proBNP predict death and hospitalisation in HF patients treated with carvedilol for six months. The clinical implication of our results is that NT-proBNP and BNP can be used as risk markers of death and cardiovascular hospitalisations in systolic HF patients receiving carvedilol without ACE inhibition
Udgivelsesdato: 2008/8

Original language	English
Journal	Cardiovascular Drugs and Therapy
Volume	22
Issue number	4
Pages (from-to)	305-311
Number of pages	6
ISSN	0920-3206
Publication status	Published - 2008

Cite this

@article{3eea53a0058f11deb05e000ea68e967b,

title = "Effect of beta-blockade and ACE inhibition on B-type natriuretic peptides in stable patients with systolic heart failure",

abstract = "Introduction The long-term effect of beta-blockade on the plasma levels of natriuretic peptides BNP and its N-terminal counterpart, NT-proBNP, as risk markers in heart failure (HF) is obscure. Methods Stable systolic HF patients from the CARMEN study were divided in groups matching their randomised treatment allocation: Carvedilol, enalapril or carvedilol+enalapril. Changes in BNP and NT-proBNP from baseline to 6 months maintenance visit were evaluated in each treatment arm. Furthermore, the prognostic value of BNP and NT-proBNP during monotherapy with carvedilol was assessed with univariate Cox proportional hazards models using a combined endpoint of all cause mortality and cardiovascular hospitalisation. Results NT-proBNP and BNP were significantly reduced after six months treatment with enalapril (NT-proBNP 1,303 to 857 pg/ml (P<0.001), BNP 119 to 85 pg/ml (P<0.001)) or carvedilol+enalapril (NT-proBNP 1,223 to 953 pg/ml (P=0.003), BNP 117 to 93 pg/ml (P=0.01)). In contrast, no change was observed in the carvedilol group (NT-proBNP 907 to 1,082 pg/ml (P=0.06), BNP 114 to 130 pg/ml (P=0.15). The prognostic value of NT-proBNP and BNP was maintained in the carvedilol group (NT-proBNP HR 1.018 95% CI (1.005-1.032), BNP 1.171 (1.088-1.260)). Conclusion Treatment of HF patients with carvedilol alone does not reduce levels of natriuretic peptides, but treatment with enalapril does. Both BNP and NT-proBNP predict death and hospitalisation in HF patients treated with carvedilol for six months. The clinical implication of our results is that NT-proBNP and BNP can be used as risk markers of death and cardiovascular hospitalisations in systolic HF patients receiving carvedilol without ACE inhibition Udgivelsesdato: 2008/8",

author = "J. Rosenberg and F. Gustafsson and W.J. Remme and G.A.J. Riegger and P.R. Hildebrandt",

note = "Times Cited: 0ArticleEnglishRosenberg, JFrederiksberg Univ Hosp, Dept Cardiol, Nordre Fasanvej 57, DK-2000 Copenhagen, DenmarkCited References Count: 36338QMSPRINGERVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDSDORDRECHT",

year = "2008",

language = "English",

volume = "22",

pages = "305--311",

journal = "Cardiovascular Drugs and Therapy",

issn = "0920-3206",

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number = "4",

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TY - JOUR

T1 - Effect of beta-blockade and ACE inhibition on B-type natriuretic peptides in stable patients with systolic heart failure

AU - Rosenberg, J.

AU - Gustafsson, F.

AU - Remme, W.J.

AU - Riegger, G.A.J.

AU - Hildebrandt, P.R.

N1 - Times Cited: 0ArticleEnglishRosenberg, JFrederiksberg Univ Hosp, Dept Cardiol, Nordre Fasanvej 57, DK-2000 Copenhagen, DenmarkCited References Count: 36338QMSPRINGERVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDSDORDRECHT

PY - 2008

Y1 - 2008

N2 - Introduction The long-term effect of beta-blockade on the plasma levels of natriuretic peptides BNP and its N-terminal counterpart, NT-proBNP, as risk markers in heart failure (HF) is obscure. Methods Stable systolic HF patients from the CARMEN study were divided in groups matching their randomised treatment allocation: Carvedilol, enalapril or carvedilol+enalapril. Changes in BNP and NT-proBNP from baseline to 6 months maintenance visit were evaluated in each treatment arm. Furthermore, the prognostic value of BNP and NT-proBNP during monotherapy with carvedilol was assessed with univariate Cox proportional hazards models using a combined endpoint of all cause mortality and cardiovascular hospitalisation. Results NT-proBNP and BNP were significantly reduced after six months treatment with enalapril (NT-proBNP 1,303 to 857 pg/ml (P<0.001), BNP 119 to 85 pg/ml (P<0.001)) or carvedilol+enalapril (NT-proBNP 1,223 to 953 pg/ml (P=0.003), BNP 117 to 93 pg/ml (P=0.01)). In contrast, no change was observed in the carvedilol group (NT-proBNP 907 to 1,082 pg/ml (P=0.06), BNP 114 to 130 pg/ml (P=0.15). The prognostic value of NT-proBNP and BNP was maintained in the carvedilol group (NT-proBNP HR 1.018 95% CI (1.005-1.032), BNP 1.171 (1.088-1.260)). Conclusion Treatment of HF patients with carvedilol alone does not reduce levels of natriuretic peptides, but treatment with enalapril does. Both BNP and NT-proBNP predict death and hospitalisation in HF patients treated with carvedilol for six months. The clinical implication of our results is that NT-proBNP and BNP can be used as risk markers of death and cardiovascular hospitalisations in systolic HF patients receiving carvedilol without ACE inhibition Udgivelsesdato: 2008/8

AB - Introduction The long-term effect of beta-blockade on the plasma levels of natriuretic peptides BNP and its N-terminal counterpart, NT-proBNP, as risk markers in heart failure (HF) is obscure. Methods Stable systolic HF patients from the CARMEN study were divided in groups matching their randomised treatment allocation: Carvedilol, enalapril or carvedilol+enalapril. Changes in BNP and NT-proBNP from baseline to 6 months maintenance visit were evaluated in each treatment arm. Furthermore, the prognostic value of BNP and NT-proBNP during monotherapy with carvedilol was assessed with univariate Cox proportional hazards models using a combined endpoint of all cause mortality and cardiovascular hospitalisation. Results NT-proBNP and BNP were significantly reduced after six months treatment with enalapril (NT-proBNP 1,303 to 857 pg/ml (P<0.001), BNP 119 to 85 pg/ml (P<0.001)) or carvedilol+enalapril (NT-proBNP 1,223 to 953 pg/ml (P=0.003), BNP 117 to 93 pg/ml (P=0.01)). In contrast, no change was observed in the carvedilol group (NT-proBNP 907 to 1,082 pg/ml (P=0.06), BNP 114 to 130 pg/ml (P=0.15). The prognostic value of NT-proBNP and BNP was maintained in the carvedilol group (NT-proBNP HR 1.018 95% CI (1.005-1.032), BNP 1.171 (1.088-1.260)). Conclusion Treatment of HF patients with carvedilol alone does not reduce levels of natriuretic peptides, but treatment with enalapril does. Both BNP and NT-proBNP predict death and hospitalisation in HF patients treated with carvedilol for six months. The clinical implication of our results is that NT-proBNP and BNP can be used as risk markers of death and cardiovascular hospitalisations in systolic HF patients receiving carvedilol without ACE inhibition Udgivelsesdato: 2008/8

M3 - Journal article

SN - 0920-3206

VL - 22

SP - 305

EP - 311

JO - Cardiovascular Drugs and Therapy

JF - Cardiovascular Drugs and Therapy

IS - 4

ER -