Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women

TY - JOUR

T1 - Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women

AU - Hansen, M

AU - Langberg, Henning

AU - Holm, L

AU - Miller, B F

AU - Petersen, S G

AU - Doessing, S

AU - Skovgaard, D

AU - Trappe, T

AU - Kjaer, M

N1 - © 2009 John Wiley & Sons A/S.

PY - 2011/2

Y1 - 2011/2

N2 - Oral contraceptive (OC) treatment has an inhibiting effect on protein synthesis in tendon and muscle connective tissue. We aimed to investigate whether OC influence myofibrillar protein turnover in young women. OC-users (24±2 years; Lindynette® n=7, Cilest® n=4) and non-OC-users (controls, 24±4 years n=12) performed one-legged kicking exercise. The next day, the myofibrillar protein fractional synthesis rate (FSR) was measured using stable isotopic tracers ((13)C-proline) while the subjects were fed standardized nutrient drinks. Simultaneously, a marker for myofibrillar protein breakdown, 3-methyl-histidine (3-MH), was measured in the interstitial fluid of the vastus lateralis. Measurements were performed in both legs. In general, myofibrillar protein FSR was lower in OC-users (two-way analysis of variance, P

AB - Oral contraceptive (OC) treatment has an inhibiting effect on protein synthesis in tendon and muscle connective tissue. We aimed to investigate whether OC influence myofibrillar protein turnover in young women. OC-users (24±2 years; Lindynette® n=7, Cilest® n=4) and non-OC-users (controls, 24±4 years n=12) performed one-legged kicking exercise. The next day, the myofibrillar protein fractional synthesis rate (FSR) was measured using stable isotopic tracers ((13)C-proline) while the subjects were fed standardized nutrient drinks. Simultaneously, a marker for myofibrillar protein breakdown, 3-methyl-histidine (3-MH), was measured in the interstitial fluid of the vastus lateralis. Measurements were performed in both legs. In general, myofibrillar protein FSR was lower in OC-users (two-way analysis of variance, P

KW - Analysis of Variance

KW - Contraceptives, Oral

KW - Energy Intake

KW - Exercise Test

KW - Female

KW - Humans

KW - Leg

KW - Methylhistidines

KW - Muscle Proteins

KW - Muscle, Skeletal

KW - Myofibrils

KW - Proline

KW - Young Adult

U2 - 10.1111/j.1600-0838.2009.01002.x

DO - 10.1111/j.1600-0838.2009.01002.x

M3 - Journal article

C2 - 19883384

SN - 0905-7188

VL - 21

SP - 62

EP - 72

JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

IS - 1

ER -